Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

Mutation scanning of the COQ2 gene in ethnic Chinese patients with multiple-system atrophy

(2015) Yong Ping Chen et al.   NEUROBIOLOGY OF AGING

Changes in total cell numbers of the basal ganglia in patients with multiple system atrophy — A stereological study

(2015) Lisette Salvesen et al.   NEUROBIOLOGY OF DISEASE

Cystatin C Triggers Neuronal Degeneration in a Model of Multiple System Atrophy

(2014) Yasuyo Suzuki et al.   AMERICAN JOURNAL OF PATHOLOGY

White matter maturation profiles through early childhood predict general cognitive ability

(2014) Sean C. L. Deoni et al.   Brain Structure & Function

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Oligodendrocyte progenitors: Adult stem cells of the central nervous system?

(2014) A.H. Crawford et al.   EXPERIMENTAL NEUROLOGY

Alpha-synuclein mRNA expression in oligodendrocytes in MSA

(2014) Yasmine T. Asi et al.   GLIA

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells

(2014) Benjamin Ettle et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Analysis of COQ2 gene in multiple system atrophy

(2014) Kotaro Ogaki et al.   Molecular Neurodegeneration

Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy

(2014) Olivier Flabeau et al.   MOVEMENT DISORDERS

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

(2014) Verena E.L. May et al.   NEUROBIOLOGY OF AGING

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2

(2014) Dominik Sakry et al.   PLOS BIOLOGY

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy

(2014) Anthony S Don et al.   Acta Neuropathologica Communications

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

(2013) Thomas Philips et al.   BRAIN

XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy

(2013) Yasuhiro Kawamoto et al.   CLINICAL NEUROPATHOLOGY

Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: Experimental evidence

(2013) Daniela Kuzdas et al.   EXPERIMENTAL NEUROLOGY

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

(2013) Iryna Prots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Clathrin-Dependent Localization of Dopamine Transporter to Surface Membranes Is Affected by α-Synuclein

(2013) Haya Kisos et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oxidative Stress Promotes Uptake, Accumulation, and Oligomerization of Extracellular α-Synuclein in Oligodendrocytes

(2013) Katharina Pukaß et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

FBXO7 Immunoreactivity in α-Synuclein—Containing Inclusions in Parkinson Disease and Multiple System Atrophy

(2013) Tianna Zhao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The natural history of multiple system atrophy: a prospective European cohort study

(2013) Gregor K Wenning et al.   LANCET NEUROLOGY

Bladder dysfunction in a transgenic mouse model of multiple system atrophy

(2013) Mathieu Boudes et al.   MOVEMENT DISORDERS

Diffusion tensor imaging of Parkinson's disease, atypical parkinsonism, and essential tremor

(2013) Janey Prodoehl et al.   MOVEMENT DISORDERS

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

FAS-Dependent Cell Death in α-Synuclein Transgenic Oligodendrocyte Models of Multiple System Atrophy

(2013) Christine L. Kragh et al.   PLoS One

Intact Olfaction in a Mouse Model of Multiple System Atrophy

(2013) Florian Krismer et al.   PLoS One

Evidence for NG2-glia Derived, Adult-Born Functional Neurons in the Hypothalamus

(2013) Sarah C. Robins et al.   PLoS One

Concepts for regulation of axon integrity by enwrapping glia

(2013) Bogdan Beirowski   Frontiers in Cellular Neuroscience

Oligodendroglia and neurotrophic factors in neurodegeneration

(2013) Andrew N. Bankston et al.   Neuroscience Bulletin

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy

(2012) Saori Odagiri et al.   ACTA NEUROPATHOLOGICA

Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

(2012) Nadia Stefanova et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Identification and Quantification of Oligodendrocyte Precursor Cells in Multiple System Atrophy, Progressive Supranuclear Palsy and Parkinson's Disease

(2012) Zeshan Ahmed et al.   BRAIN PATHOLOGY

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

(2012) Kiren Ubhi et al.   EXPERIMENTAL NEUROLOGY

Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury

(2012) Peijun Ju et al.   GLIA

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

(2012) Gwendolyn Behrendt et al.   GLIA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes

(2012) Lisa Schwarz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Properties and Fate of Oligodendrocyte Progenitor Cells in the Corpus Callosum, Motor Cortex, and Piriform Cortex of the Mouse

(2012) L. E. Clarke et al.   JOURNAL OF NEUROSCIENCE

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2

(2012) Dimphna H. Meijer et al.   NATURE REVIEWS NEUROSCIENCE

Neuronal to oligodendroglial alpha-synuclein redistribution in a double transgenic model of multiple system atrophy

(2012) Edward Rockenstein et al.   NEUROREPORT

CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease

(2012) Barbara B. Bendlin et al.   PLoS One

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Prolonged myelination in human neocortical evolution

(2012) D. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Neuropathology underlying clinical variability in patients with synucleinopathies

(2011) Glenda M. Halliday et al.   ACTA NEUROPATHOLOGICA

White matter lesions defined by diffusion tensor imaging in older adults

(2011) Stephen A. Back et al.   ANNALS OF NEUROLOGY

Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy

(2011) Y. Honjo et al.   CLINICAL NEUROPATHOLOGY

Differential Prefrontal White Matter Development in Chimpanzees and Humans

(2011) Tomoko Sakai et al.   CURRENT BIOLOGY

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

Protein Disulfide Isomerase Immunopositive Glial Cytoplasmic Inclusions in Patients With Multiple System Atrophy

(2011) Yasuyuki Honjo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy?

(2011) William D. Richardson et al.   NEURON

Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy

(2011) Y. Chiba et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Myeloperoxidase Inhibition Ameliorates Multiple System Atrophy-Like Degeneration in a Transgenic Mouse Model

(2011) Nadia Stefanova et al.   NEUROTOXICITY RESEARCH

Multiple system atrophy: a clinical and neuropathological perspective

(2011) Kiren Ubhi et al.   TRENDS IN NEUROSCIENCES

Focal demyelination in Alzheimer’s disease and transgenic mouse models

(2010) Stanislaw Mitew et al.   ACTA NEUROPATHOLOGICA

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

(2010) Maya K. Desai et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeted overexpression of human α-synuclein in oligodendroglia induces lesions linked to MSA -like progressive autonomic failure

(2010) Sylvia Stemberger et al.   EXPERIMENTAL NEUROLOGY

Membrane Lipid Modification by Docosahexaenoic Acid (DHA) Promotes the Formation of α-Synuclein Inclusion Bodies Immunopositive for SUMO-1 in Oligodendroglial Cells After Oxidative Stress

(2010) Michael Riedel et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes up-regulation of heme oxygenase-1 (HSP32)

(2010) Annette Brand et al.   JOURNAL OF NEUROCHEMISTRY

Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination

(2010) Alastair Wilkins et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors

(2010) K. Ubhi et al.   JOURNAL OF NEUROSCIENCE

Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex

(2010) F. Guo et al.   JOURNAL OF NEUROSCIENCE

Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy

(2010) Kouki Makioka et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Amyloid β1–42 oligomer inhibits myelin sheet formation in vitro

(2010) Makoto Horiuchi et al.   NEUROBIOLOGY OF AGING

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy

(2010) Kiren Ubhi et al.   NEUROREPORT

Frontal White Matter Volume Is Associated with Brain Enlargement and Higher Structural Connectivity in Anthropoid Primates

(2010) Jeroen Bert Smaers et al.   PLoS One

White matter maturation reshapes structural connectivity in the late developing human brain

(2010) P. Hagmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNCAvariants are associated with increased risk for multiple system atrophy

(2009) Sonja W. Scholz et al.   ANNALS OF NEUROLOGY

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

(2009) Ben Emery et al.   CELL

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells

(2009) Christine L. Kragh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Promotes the Recruitment of Tau to Protein Inclusions in Oligodendroglial Cells: Effects of Oxidative and Proteolytic Stress

(2009) Michael Riedel et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Selective Nuclear Shrinkage of Oligodendrocytes Lacking Glial Cytoplasmic Inclusions in Multiple System Atrophy: A 3-Dimensional Volumetric Study

(2009) Naoto Uyama et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression

(2009) Yun Ju C. Song et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy

(2009) Kiren Ubhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Multiple system atrophy: an update

(2009) Nadia Stefanova et al.   LANCET NEUROLOGY

Proposed neuroimaging criteria for the diagnosis of multiple system atrophy

(2009) David J. Brooks et al.   MOVEMENT DISORDERS

Association of Metallothionein-III with Oligodendroglial Cytoplasmic Inclusions in Multiple System Atrophy

(2009) D. L. Pountney et al.   NEUROTOXICITY RESEARCH

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy

(2009) Ammar Al-Chalabi et al.   PLoS One

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

The origin of the myelination program in vertebrates

(2008) B. Zalc et al.   CURRENT BIOLOGY

Oligodendrocytes and myelination: The role of iron

(2008) Bozho Todorich et al.   GLIA

Accumulation of HtrA2/Omi in Neuronal and Glial Inclusions in Brains With α-Synucleinopathies

(2008) Yasuhiro Kawamoto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation

(2008) N. K. Iwata et al.   NEUROLOGY

Glial cytoplasmic inclusions and tissue injury in multiple system atrophy: A quantitative study in white matter (olivopontocerebellar system) and gray matter (nigrostriatal system)

(2008) Keisuke Ishizawa et al.   NEUROPATHOLOGY

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING

The solubility of α-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

(2003) Bruce C. V. Campbell et al.   JOURNAL OF NEUROCHEMISTRY