Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues

(2016) Yuki Yasueda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

Targeting non-canonical autophagy overcomes erlotinib resistance in tongue cancer

(2016) Keqiang huang et al.   TUMOR BIOLOGY

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

(2016) Erik S. Knudsen et al.   Oncotarget

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

ATG12–ATG3 connects basal autophagy and late endosome function

(2015) Lyndsay Murrow et al.   Autophagy

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

(2015) D Grahame Hardie   CURRENT OPINION IN CELL BIOLOGY

Unsaturated fatty acids induce non-canonical autophagy

(2015) M. Niso-Santano et al.   EMBO JOURNAL

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Glutathione Depletion Induces Spermatogonial Cell Autophagy

(2015) Héctor Mancilla et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cysteine-mediated redox signalling in the mitochondria

(2015) D. W. Bak et al.   Molecular BioSystems

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Regulated Cell Death: Signaling and Mechanisms

(2014) Avi Ashkenazi et al.   Annual Review of Cell and Developmental Biology

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

A nonapoptotic role for CASP2/caspase 2

(2014) Meenakshi Tiwari et al.   Autophagy

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

(2014) L. M. Lindqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

(2014) Jia Shen et al.   Cell Reports

A Competitive Chemical-Proteomic Platform To Identify Zinc-Binding Cysteines

(2013) Nicholas J. Pace et al.   ACS Chemical Biology

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

Autophagy and cell death

(2013) Tohru Yonekawa et al.   Essays in Biochemistry

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62/Sequestosome-1 Up-regulation Promotes ABT-263-induced Caspase-8 Aggregation/Activation on the Autophagosome

(2013) Shengbing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

(2013) Qian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

(2013) Assaf D. Rubinstein et al.   JOURNAL OF CELL SCIENCE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Regulation of Cell Death

(2013) S. W. G. Tait et al.   Cold Spring Harbor Perspectives in Biology

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Glutathione and modulation of cell apoptosis

(2012) Magdalena L. Circu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Regulation of the Autophagic Bcl-2/Beclin 1 Interaction

(2012) Jean-Paul Decuypere et al.   Cells

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells

(2011) Jin-Yi Yang et al.   Autophagy

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

(2011) Markus Bach et al.   BIOCHEMICAL JOURNAL

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

(2011) Chahrazade Kantari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Autophagic degradation of active caspase-8

(2010) Wen Hou et al.   Autophagy

Involvement of caspase-9 in autophagy-mediated cell survival pathway

(2010) Hyo-Soon Jeong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

(2010) Maria Chiara Maiuri et al.   EMBO JOURNAL

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY