Article
Peripheral Vascular Disease
Xue Liu, Hongjiao Du, Yilong Pan, Xiaodong Li
Summary: Pathological cardiac hypertrophy is an adaptive reaction to pressure or volume overload, and autophagy plays a critical role in this process. Vacuole membrane protein 1 (VMP1), an endoplasmic reticulum transmembrane protein, is effective in activating autophagy. This study investigated the potential mechanisms of VMP1 in pressure overload-induced pathological cardiac hypertrophy, and found that VMP1 protects against cardiac hypertrophy by inducing autophagic flux.
MICROVASCULAR RESEARCH
(2023)
Article
Food Science & Technology
Deqiang Fu, Xingyue Liang, Yuxuan Jiang, Jieping Liu, Xiaosi Lin, Quan Yang, Xue Chen, Ping Huang, Wei Wang, Wenlin Wu
Summary: Iron accumulation in the brain has been implicated in the pathogenesis of various neurodegenerative diseases. Autophagy induction has been proposed as a potential therapeutic strategy, but the relationship between autophagy and iron is not well understood. This study found that iron induces autophagosome accumulation and disrupts the autophagic flux in microglia, which may contribute to iron neurotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Takeshi Yamamoto, Yoshitsugu Takabatake, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Tomonori Kimura, Isao Matsui, Jun-Ya Kaimori, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka
Summary: The study found that supplementation with EPA can alleviate renal lipotoxicity by reducing phospholipid accumulation in lysosomes, improving mitochondrial dysfunction, reducing inflammation and fibrosis. EPA alleviates renal lipotoxicity by improving lysosomal function and autophagic flux in both high-fat diet-fed mice and isolated PTECs cultured in palmitic acid, indicating its potential as a novel treatment for obesity-related kidney diseases.
Review
Cardiac & Cardiovascular Systems
Jihoon Nah, Daniela Zablocki, Junichi Sadoshima
Summary: Understanding the mechanisms of cell death in cardiomyocytes is crucial for the treatment of heart failure, with a focus on autophagy-related cell death. Autophagy plays a key role in cellular quality control for survival, but dysregulation can lead to cell death.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Plant Sciences
Gil-Sun Park, Bokyung Park, Mi-Young Lee
Summary: The incidence of skin cancer, particularly melanoma, a highly malignant tumor, has been increasing. Plant-derived berberine has been found to induce cell death in melanoma cells through a mechanism involving inhibition of apoptosis and promotion of autophagy. Further investigation revealed that berberine induces autophagic cell death by inactivating the Akt/mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Weiwei Zhang, Jiayi Liu, Zekang Wu, Guanwei Fan, Zhuo Yang, Chunhua Liu
Summary: Appropriate exercise such as voluntary wheel-running can induce physiological cardiac hypertrophy, and Notch1 plays an important role in this process. However, the experimental results are inconsistent. This study aimed to explore the role of Notch1 in physiological cardiac hypertrophy through various tests, and the findings suggest that Notch1 plays a critical role in physiologic cardiac hypertrophy through the p38 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Min Xie, Geoffrey W. Cho, Yongli Kong, Dan L. Li, Francisco Altamirano, Xiang Luo, Cyndi R. Morales, Nan Jiang, Gabriele G. Schiattarella, Herman May, Jessica Medina, John M. Shelton, Anwarul Ferdous, Thomas G. Gillette, Joseph A. Hill
Summary: The study tested the use of an autophagy-inducing peptide, TB, to protect against reperfusion injury by reducing reactive oxygen species. It was found that TB reduced infarct size, improved contractile function, and decreased oxidative stress by increasing autophagic flux.
CIRCULATION RESEARCH
(2021)
Article
Oncology
Huynh Diem Thi Ngoc, Yujin Jin, Chang-Seon Myung, Kyung-Sun Heo
Summary: Breast cancer is the most common cause of cancer-related deaths among women globally. Ginsenoside Rh1 exhibits potential anticancer effects on breast cancer cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway.
Article
Pharmacology & Pharmacy
HuiTing Liu, ZhiXiang Zhou, HuaNian Deng, Zhen Tian, ZeFan Wu, XiYan Liu, Zhong Ren, ZhiSheng Jiang
Summary: Pathological cardiac hypertrophy is a major cause of heart failure and lacks effective prevention or treatment. This study found that Trim65 inhibits cardiac hypertrophy by suppressing mitochondrial-dependent apoptosis and autophagy pathways. Genes related to mitochondrial-dependent apoptosis and associated with Trim65 could be potential therapeutic targets for cardiac hypertrophy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Shunan Tang, Sina Cai, Shuai Ji, Xiaojin Yan, Weijia Zhang, Xue Qiao, Hongquan Zhang, Min Ye, Siwang Yu
Summary: Isoangustone A induces cell death through activation of AMPK-mediated autophagy, inhibiting tumor growth. Further investigation is warranted for its potential as an anti-cancer agent.
Article
Biochemistry & Molecular Biology
Robert Walmsley, Derek S. Steele, Georgina M. Ellison-Hughes, Sotiris Papaspyros, Andrew J. Smith
Summary: This study investigated the effects of imatinib, a receptor tyrosine kinase inhibitor, on human cardiac progenitor cells. It was found that imatinib reduced cell viability, depolarized mitochondria, increased lysosome and autophagosome content, and induced cell death through necroptosis. However, the toxicity could be rescued by RIP1 inhibition and autophagy played a partial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tsu-Jen Kuo, Yen-Hsuan Jean, Po-Chang Shih, Shu-Yu Cheng, Hsiao-Mei Kuo, Yi-Ting Lee, Yu-Cheng Lai, Chung-Chih Tseng, Wu-Fu Chen, Zhi-Hong Wen
Summary: This study evaluated the effects of marine-derived triterpene stellettin B on oral squamous cell carcinoma (OSCC) cells and found that stellettin B induced cell death through mechanisms including endoplasmic reticulum stress, mitochondrial stress, apoptosis, and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Li-zhen Liao, Zhi-chong Chen, Sui-Sui Wang, Wen-bin Liu, Xiao-dong Zhuang
Summary: This study demonstrated that klotho deficiency in mice leads to decreased lifespan, impaired cardiac function, reduced autophagic activity, and increased apoptotic activity. Exogenous klotho supplementation protected against cardiomyocyte aging, reversed changes in autophagy and apoptosis induced by D-galactose, and prevented oxidative stress and cytotoxicity. It suggests klotho has a protective effect on cardiac aging through activation of autophagy and inhibition of apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Chen Yang, Yanchun Li, Wanye Hu, Xu Wang, Jiayu Hu, Chen Yuan, Chaoting Zhou, Hairui Wang, Jing Du, Ying Wang, Xiangmin Tong
Summary: TEOA inhibits proliferation and migration of pancreatic cancer cells by inducing mitochondrial dysfunction and ROS-dependent autophagic cell death, suggesting its potential as a promising therapeutic agent for pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junmei Li, Lin Qi, Ziyang Diao, Mengyu Zhang, Bin Li, Yunyi Zhai, Mingyue Hao, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang
Summary: Studies have shown that the Brucella effector BtpB manipulates host cell infection by promoting apoptosis and inhibiting autophagy. In addition, the autophagy inhibitor chloroquine can reduce intracellular survival of Brucella.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)