Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

(2011) Yochai Birnbaum et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury

(2011) Yuan Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation

(2011) K.-i. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FoxO Family in Cardiac Function and Dysfunction

(2010) Sarah M. Ronnebaum et al.   Annual Review of Physiology

Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: Slayer or savior?

(2010) Yingmei Zhang et al.   Autophagy

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling

(2010) Nehmat Ghaboura et al.   BASIC RESEARCH IN CARDIOLOGY

Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion

(2010) L. Breivik et al.   BASIC RESEARCH IN CARDIOLOGY

Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats

(2010) C. Penna et al.   BASIC RESEARCH IN CARDIOLOGY

Blockage of Angiotensin II type 2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation

(2010) M. S. Carneiro-Ramos et al.   BASIC RESEARCH IN CARDIOLOGY

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

Role of autophagy in heart failure associated with aging

(2010) Guido R. Y. De Meyer et al.   HEART FAILURE REVIEWS

Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

(2010) Ken Shinmura et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging

(2010) Ryo-hei Iida et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy and amino acid homeostasis are required for chronological longevity inSaccharomyces cerevisiae

(2009) Ashley L. Alvers et al.   AGING CELL

Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA

(2009) Smadar Yitzhaki et al.   BASIC RESEARCH IN CARDIOLOGY

Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3β/mTOR signaling pathway

(2009) Gabriela Placoná Diniz et al.   BASIC RESEARCH IN CARDIOLOGY

Cardioprotection requires taking out the trash

(2009) Roberta A. Gottlieb et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac regulation by phosphoinositide 3-kinases and PTEN

(2009) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH

Loss of cardioprotection with ageing

(2009) K. Boengler et al.   CARDIOVASCULAR RESEARCH

Transgenic Overexpression of Aldehyde Dehydrogenase-2 Rescues Chronic Alcohol Intake–Induced Myocardial Hypertrophy and Contractile Dysfunction

(2009) Thomas A. Doser et al.   CIRCULATION

Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

(2009) Yasutaka Inuzuka et al.   CIRCULATION

Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/Reperfusion Injury by Suppressed Autophagy and Increased Cell Death

(2009) Jiang Qian et al.   CIRCULATION RESEARCH

Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue

(2009) Shigeki Miyamoto et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cathepsin B-mediated Autophagy Flux Facilitates the Anthrax Toxin Receptor 2-mediated Delivery of Anthrax Lethal Factor into the Cytoplasm

(2009) Soon-Duck Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis

(2009) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Deficiency of Insulin-Like Growth Factor 1 Reduces Sensitivity to Aging-Associated Cardiomyocyte Dysfunction

(2008) Qun Li et al.   REJUVENATION RESEARCH

Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice

(2007) Kerstin Boengler et al.   CIRCULATION RESEARCH