Key autophagic targets and relevant small-molecule compounds in cancer therapy

AKT/mTOR and c-Jun N-terminal kinase signaling pathways are required for chrysotile asbestos-induced autophagy

(2014) Ziying Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Survivin as a Preferential Target for Cancer Therapy

(2014) Mahsa Mobahat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat

(2014) Xiang Shan Ren et al.   PLoS One

IPF Fibroblasts Are Desensitized to Type I Collagen Matrix-Induced Cell Death by Suppressing Low Autophagy via Aberrant Akt/mTOR Kinases

(2014) Richard Seonghun Nho et al.   PLoS One

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

mTOR, AMBRA1, and autophagy: An intricate relationship

(2013) Francesca Nazio et al.   CELL CYCLE

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Beclin-1: Autophagic regulator and therapeutic target in cancer

(2013) Lei-lei Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer

(2013) B Liu et al.   Cell Death & Disease

Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway

(2012) Yuan-chao Ye et al.   ACTA PHARMACOLOGICA SINICA

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Activation of ERK–p53 and ERK-Mediated Phosphorylation of Bcl-2 Are Involved in Autophagic Cell Death Induced by the c-Met Inhibitor SU11274 in Human Lung Cancer A549 Cells

(2012) Ying Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Galangin Induces Autophagy through Upregulation of p53 in HepG2 Cells

(2012) Min Wen et al.   PHARMACOLOGY

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

(2012) Xiaohua Li et al.   Nature Communications

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

(2011) Ning Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1

(2011) H. Li et al.   CANCER RESEARCH

Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells

(2011) M. D. Bareford et al.   CANCER RESEARCH

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

In vitro and in vivo anti-melanoma action of metformin

(2011) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Core signaling pathways of survival/death in autophagy-related cancer networks

(2011) Shu-ya Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Prazosin induces p53-mediated autophagic cell death in H9C2 cells

(2011) Yi-Fan Yang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

Autophagic pathways as new targets for cancer drug development

(2010) Bo Liu et al.   ACTA PHARMACOLOGICA SINICA

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum

(2010) J Lian et al.   CELL DEATH AND DIFFERENTIATION

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

(2010) S Michiorri et al.   CELL DEATH AND DIFFERENTIATION

The mTOR Pathway: A New Target in Cancer Therapy

(2010) L. Ciuffreda et al.   CURRENT CANCER DRUG TARGETS

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

p53 and autophagy in cancer: Guardian of the genome meets guardian of the proteome

(2010) Kevin M. Ryan   EUROPEAN JOURNAL OF CANCER

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

(2010) Qiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

(2010) Nobumichi Furuta et al.   MOLECULAR BIOLOGY OF THE CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells

(2010) Xia Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia

(2009) Roman Crazzolara et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Atg5 Regulates Phenethyl Isothiocyanate-Induced Autophagic and Apoptotic Cell Death in Human Prostate Cancer Cells

(2009) A. Bommareddy et al.   CANCER RESEARCH

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

PUMA- and Bax-induced autophagy contributes to apoptosis

(2009) K S Yee et al.   CELL DEATH AND DIFFERENTIATION

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

(2009) E Laane et al.   CELL DEATH AND DIFFERENTIATION

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

(2009) T.-J. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology