Article
Medicine, Research & Experimental
Dezhong Zheng, Mingyu Zhang, Tingrong Liu, Tao Zhou, Anna Shen
Summary: The study reveals that OPG induces cardiomyocyte hypertrophy and inhibits autophagy through the FAK/Beclin1 signal pathway. The phosphorylation of FAK plays a key role in this process.
Article
Urology & Nephrology
Imane Bensaada, Blaise Robin, Joelle Perez, Yann Salemkour, Anna Chipont, Marine Camus, Mathilde Lemoine, Lea Guyonnet, Helene Lazareth, Emmanuel Letavernier, Carole Henique, Pierre-Louis Tharaux, Olivia Lenoir
Summary: The study revealed that chronic angiotensin II-induced hypertension inhibits autophagy in mouse glomeruli, leading to accelerated podocyte injury when autophagy-related gene Atg5 is deleted. However, transgenic mice expressing the endogenous calpain inhibitor calpastatin showed higher podocyte autophagy and resistance to angiotensin II-induced inhibition, demonstrating a potential protective effect against podocyte damage and albuminuria. These findings suggest that preventing calpain-mediated inhibition of autophagy may offer a new therapeutic strategy for nephropathies associated with high renin-angiotensin system activity.
KIDNEY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Miyuki Kobara, Hiroe Toba, Tetsuo Nakata
Summary: Autophagy induced by angiotensin II helps to remove ROS-producing mitochondria, benefiting against myocyte apoptosis in the early phase but with limited benefit in the late phase of angiotensin II stimulation.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Virology
Zi Li, Feng Gao, Yungang Lan, Jiyu Guan, Jing Zhang, Huijun Lu, Kui Zhao, Wenqi He
Summary: The study reveals a novel mechanism of noncanonical autophagy independent of ULK1 during PHEV infection, where productive autophagosome biogenesis bypasses the regulation of ULK1 kinase. BECN1 acts as a legitimate substrate for ULK1-independent neural autophagy, and ectopic expression of BECN1 somewhat enhances PHEV replication. These findings shed light on the complex interactions between the neurotropic beta-CoV and the host, offering insights for potential therapeutic strategies targeting noncanonical autophagy in treating beta-CoV diseases.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuichiro Mishima, Peixun Han, Kota Ishibashi, Seisuke Kimura, Shintaro Iwasaki
Summary: The control of mRNA stability is crucial for regulating gene expression patterns. Recent studies have found that the composition of codons in the open reading frame affects mRNA stability in various organisms. Experimental analyses are needed to clarify the effects of codons on mRNA stability and the pathways of cotranslational mRNA decay.
Article
Cell Biology
Ruili Dang, Mengqi Yang, Changmeng Cui, Changshui Wang, Wenyuan Zhang, Chunmei Geng, Wenxiu Han, Pei Jiang
Summary: Activation of ACE2/Ang(1-7)/MasR axis triggers the FOXO1-autophagy pathway, inducing antioxidant enzymes SOD and CAT, leading to neuroprotection against neuroinflammation.
Article
Cell Biology
Xiufeng Chu, Xiang Xiao, Guangchuan Wang, Ahmed Uosef, Xiaohua Lou, Preston Arnold, Yixuan Wang, Gangcheng Kong, Mou Wen, Laurie J. Minze, Xian C. C. Li
Summary: This study shows that the cytolytic activity of Gasdermin D N-terminal pore-forming domain (GD-NT) is negatively regulated by AMP-activated protein kinase (AMPK). AMPK phosphorylates GD-NT at serine 46, which alters its oligomerization and inhibits its pore-forming ability. The negative regulation of GD-NT by AMPK impacts its anti-tumor activity and promotes aggressive tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Xiaoli Ju, Heng Zhang, Jiayou Wang, Zhonghe Sun, Lanfang Guo, Qiang Wang
Summary: The aim of this study was to investigate the mechanisms of SK-induced pyroptosis in tumour cells and mice. Cell deaths were analysed using LDH and CCK-8 assays and western blotting. The activation of BAX/caspase-3 signalling and intracellular ROS generation were found to be essential for GSDME-mediated pyroptosis induced by SK. MAPK14/p38 alpha, a ROS sensor, was also found to modulate SK-induced autophagy and affect GSDME-dependent pyroptosis.
Article
Cell Biology
Zikai Zhou, Guiqin He, Xiaoyun Zhang, Xin Lv, Xiaolin Zhang, An Liu, Shuting Xia, Hao Xie, Rui Dang, Lifang Han, Junxia Qi, Yanghong Meng, Shunying Yu, Wei Xie, Zhengping Jia
Summary: Synaptic scaling, a form of homeostatic plasticity, is initiated by the release of neurite growth-promoting factor 2 (NGPF2) following TTX treatment, leading to actin reorganization and stabilization of AMPARs at the synapse via the ALK-LIMK-cofilin signaling pathway.
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Thomas G. Martin, Valerie D. Myers, Praveen Dubey, Shubham Dubey, Edith Perez, Christine S. Moravec, Monte S. Willis, Arthur M. Feldman, Jonathan A. Kirk
Summary: The authors demonstrate that decreased expression of BAG3 in the heart leads to reduced sarcomere protein turnover, impacting mechanical function, and that sarcomere force-generating capacity can be restored through BAG3 gene therapy.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Grazielle A. de Sa, Anna Clara P. M. dos Santos, Julia M. Nogueira, Diogo M. dos Santos, Flavio A. Amaral, Erika C. Jorge, Marcelo V. Caliari, Celso M. Queiroz-Junior, Anderson J. Ferreira
Summary: This study evaluated the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis in vitro and in vivo. Results showed that Ang II induces chondrocyte death and joint tissue damages associated with OA, and its modulation can be a therapeutic strategy in osteoarthritis. Inhibiting Ang II synthesis improved OARSI score, induced chondroprotection, and reduced leukocyte recruitment, suggesting potential therapeutic benefits in OA.
Article
Pharmacology & Pharmacy
Chang-Bo Zheng, Wen-Cong Gao, Mingxu Xie, Zhichao Li, Xin Ma, Wencong Song, Dan Luo, Yongxiang Huang, Jichen Yang, Peng Zhang, Yu Huang, Weimin Yang, Xiaoqiang Yao
Summary: This study demonstrates that Ang II promotes excessive cardiomyocyte autophagy through SOCE/Orai1, which are major contributing factors in cardiac hypertrophy. Inhibition of SOCE or silencing of Orai1 attenuated Ang II-induced cardiomyocyte autophagy and pathological cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Wanlu Du, Mingxue Gu, Meiqin Hu, Prateeksunder Pinchi, Wei Chen, Michael Ryan, Timothy Nold, Ahmed Bannaga, Haoxing Xu
Summary: During tumor progression, lysosome function is often maladaptively upregulated to meet the high energy demand needed for cancer cell hyper-proliferation and invasion. In metastatic melanoma cells, TRPML1 is dramatically upregulated, and its synthetic agonists can induce necrotic cell death specifically in these cells. This cell death is caused by mitochondria swelling and dysfunction leading to ATP depletion.
Article
Cell Biology
Huanhuan Wang, Ge Yang, Yuan Tian, Jinjie Li, Lingbin Meng, Xin Jiang, Ying Xin
Summary: Sulforaphane (SFN) prevents angiotensin II-induced cardiomyocyte apoptosis by activating Nrf2 and inhibiting HDACs, leading to increased histone H3 acetylation levels.
Article
Biochemistry & Molecular Biology
Martin Nybo Andersen, Lasse Skibsbye, Chuyi Tang, Frederic Petersen, Nanna MacAulay, Hanne Borger Rasmussen, Thomas Jespersen
Article
Cell Biology
Li Lin, Xuebo Liu, Jianfeng Xu, Liqing Weng, Jun Ren, Junbo Ge, Yunzeng Zou
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2015)
Article
Cell Biology
Li Lin, Xuebo Liu, Jianfeng Xu, Liqing Weng, Jun Ren, Junbo Ge, Yunzeng Zou
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2016)
Article
Cardiac & Cardiovascular Systems
Zhiwen Ding, Jie Yuan, Yanyan Liang, Jian Wu, Hui Gong, Yong Ye, Guoliang Jiang, Peipei Yin, Yang Li, Guoping Zhang, Chunjie Yang, Junjie Guo, Zhidan Chen, Xingxu Wang, Liqing Weng, Yunzeng Zou
INTERNATIONAL HEART JOURNAL
(2017)
Article
Multidisciplinary Sciences
Johanna Tommiska, Johanna Kansakoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J. Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jorgen K. Kanters, Paivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Laaperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L. Andoniadou, Joel A. Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Laura Andreasen, Gustav Ahlberg, Chuyi Tang, Charlotte Andreasen, Jacob P. Hartmann, Jacob Tfelt-Hansen, Elijah R. Behr, Steen Pehrson, Stig Haunso, LuCamp, Peter E. Weeke, Thomas Jespersen, Morten S. Olesen, Jesper H. Svendsen
EUROPEAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Chemistry, Multidisciplinary
Li-qing Weng, Wen-bin Zhang, Yong Ye, Pei-pei Yin, Jie Yuan, Xing-xu Wang, Le Kang, Sha-sha Jiang, Jie-yun You, Jian Wu, Hui Gong, Jun-bo Ge, Yun-zeng Zou
ACTA PHARMACOLOGICA SINICA
(2014)
Article
Cardiac & Cardiovascular Systems
Lei Yuan, Jussi T. Koivumaki, Bo Liang, Lasse G. Lorentzen, Chuyi Tang, Martin N. Andersen, Jesper H. Svendsen, Jacob Tfelt-Hansen, Molly Maleckar, Nicole Schmitt, Morten S. Olesen, Thomas Jespersen
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2014)
Article
Physiology
Mark A. Skarsfeldt, Helena Carstensen, Lasse Skibsbye, Chuyi Tang, Rikke Buhl, Bo H. Bentzen, Thomas Jespersen
PHYSIOLOGICAL REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Chuyi Tang, Lasse Skibsbye, Lei Yuan, Bo H. Bentzen, Thomas Jespersen
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2015)