Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms

(2015) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques

(2014) Marijke J.E. Kuijpers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Identification of platelet function defects by multi-parameter assessment of thrombus formation

(2014) Susanne M. de Witt et al.   Nature Communications

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation

(2013) R. van Kruchten et al.   BLOOD

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Mechanism of Integrin αIIbβ3Closure in Procoagulant Platelets

(2013) Nadine J. A. Mattheij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

(2013) Carsten Deppermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

(2013) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation

(2013) S. R. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential Channels Function as a Coincidence Signal Detector Mediating Phosphatidylserine Exposure

(2013) M. T. Harper et al.   Science Signaling

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Antithrombotic Potential of Blockers of Store-Operated Calcium Channels in Platelets

(2012) Roger van Kruchten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Key role of integrin αIIbβ3 signaling to Syk kinase in tissue factor-induced thrombin generation

(2012) Paola E. J. van der Meijden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation

(2012) Mi Wang et al.   CIRCULATION

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

(2012) Harald WA Ehlen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Platelet-based coagulation: different populations, different functions

(2012) J. W. M. HEEMSKERK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Measurement of whole blood thrombus formation using parallel-plate flow chambers – a practical guide

(2012) Roger Van Kruchten et al.   PLATELETS

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escherichia coliα-Hemolysin Triggers Shrinkage of Erythrocytes via KCa3.1 and TMEM16A Channels with Subsequent Phosphatidylserine Exposure

(2010) Marianne Skals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension

(2009) Sebastian Brähler et al.   CIRCULATION

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly

(2008) Ivica Grgic et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY