Platelet-based coagulation: different populations, different functions

Identification of Different Proaggregatory Abilities of Activated Platelet Subpopulations

(2012) Alena O. Yakimenko et al.   BIOPHYSICAL JOURNAL

Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity

(2012) G. E. Gilbert et al.   BLOOD

Intracellular cyclophilin A is an important Ca2+ regulator in platelets and critically involved in arterial thrombus formation

(2012) M. Elvers et al.   BLOOD

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Key role of integrin αIIbβ3 signaling to Syk kinase in tissue factor-induced thrombin generation

(2012) Paola E. J. van der Meijden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Murine Hematopoietic Cell Tissue Factor Pathway Inhibitor Limits Thrombus Growth

(2011) Susan A. Maroney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa

(2011) M. Al-Tamimi et al.   BLOOD

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Polyphosphate is a cofactor for the activation of factor XI by thrombin

(2011) S. H. Choi et al.   BLOOD

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Store-operated calcium entry and non-capacitative calcium entry have distinct roles in thrombin-induced calcium signalling in human platelets

(2011) Matthew T. Harper et al.   CELL CALCIUM

Platelet Protease Nexin-1, a Serpin That Strongly Influences Fibrinolysis and Thrombolysis

(2011) Yacine Boulaftali et al.   CIRCULATION

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factor XIII supports platelet activation and enhances thrombus formation by matrix proteins under flow conditions

(2011) S. G. MAGWENZI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein

(2011) R. NERGIZ-UNAL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies

(2011) T. LHERMUSIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PKC inhibition markedly enhances Ca2+ signaling and phosphatidylserine exposure downstream of protease-activated receptor-1 but not protease-activated receptor-4 in human platelets

(2011) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The septic milieu triggers expression of spliced tissue factor mRNA in human platelets

(2011) M. T. RONDINA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis

(2011) F. AHMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular protein disulfide isomerase regulates feedback activation of platelet thrombin generation via modulation of coagulation factor binding

(2011) K. JURK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Defective diacylglycerol-induced Ca2+entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets

(2011) G. RAMANATHAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Properties of Procoagulant Platelets

(2010) Ammon M. Fager et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tissue Factor and Thrombosis Models

(2010) Colin A. Kretz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular Mechanisms Underlying the Formation of Circulating Microparticles

(2010) Olivier Morel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Procoagulant platelets: are they necrotic?

(2010) S. P. Jackson et al.   BLOOD

A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIb  N-terminal extracellular domain

(2010) C. Ravanat et al.   BLOOD

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

AMPK  2 subunit is involved in platelet signaling, clot retraction, and thrombus stability

(2010) V. Randriamboavonjy et al.   BLOOD

von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models

(2010) A. Brill et al.   BLOOD

A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets

(2010) D. H. Thomas et al.   BLOOD

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

(2010) J. M. E. M. Cosemans et al.   BLOOD

Polyphosphate exerts differential effects on blood clotting, depending on polymer size

(2010) S. A. Smith et al.   BLOOD

The molecular identity of the mitochondrial Ca2+ sequestration system

(2010) Anatoly A. Starkov   FEBS Journal

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen

(2010) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation

(2010) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syk-dependent Phosphorylation of CLEC-2

(2010) Sonia Séverin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet receptor signaling in thrombus formation

(2010) David Stegner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cγ2

(2010) M. ELVERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner

(2010) T. C. WHITE-ADAMS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatial Distribution of Factor Xa, Thrombin, and Fibrin(ogen) on Thrombi at Venous Shear

(2010) Michelle A. Berny et al.   PLoS One

Identification of Coagulation Factor XI as a Ligand for Platelet Apolipoprotein E Receptor 2 (ApoER2)

(2009) Tara C. White-Adams et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired activation of platelets lacking protein kinase C-  isoform

(2009) B. Nagy et al.   BLOOD

Dual role of collagen in factor XII-dependent thrombus formation

(2009) P. E. J. van der Meijden et al.   BLOOD

Impaired clot retraction in factor XIII A subunit-deficient mice

(2009) K. Kasahara et al.   BLOOD

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide 3-Kinase p110β Regulates Integrin αIIbβ3Avidity and the Cellular Transmission of Contractile Forces

(2009) Simone M. Schoenwaelder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

(2009) Hitoshi Takizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

(2009) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore

(2009) Valery Leytin et al.   LABORATORY INVESTIGATION

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex

(2008) R. Majumder et al.   BLOOD

Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation

(2008) A. Braun et al.   BLOOD

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth

(2008) A. Ono et al.   BLOOD

The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface

(2008) C. Weeterings et al.   BLOOD

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

(2008) David Varga-Szabo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities

(2008) A. L. FRELINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2

(2008) T. C. WHITE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure

(2008) J. SHI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Key Role of Platelet Procoagulant Activity in Tissue Factor-and Collagen-Dependent Thrombus Formation in Arterioles and VenulesIn VivoDifferential Sensitivity to Thrombin Inhibition

(2008) Marijke J.E. Kuijpers et al.   MICROCIRCULATION

Critical Role of FcR γ-Chain, LAT, PLCγ2 and Thrombin in Arteriolar Thrombus Formation upon Mild, Laser-Induced Endothelial InjuryIn Vivo

(2008) Neena Kalia et al.   MICROCIRCULATION

Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1

(2008) David Varga-Szabo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The active metabolite of prasugrel effectively blocks the platelet P2Y12receptor and inhibits procoagulant and pro-inflammatory platelet responses

(2008) Heather M. Judge et al.   PLATELETS

Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin V

(2008) Abdul-Majeed Albanyan et al.   TRANSFUSION