Proteasome function is required for platelet production

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

(2014) Z.-J. Liu et al.   BLOOD

CLEC-2 is required for development and maintenance of lymph nodes

(2014) C. Benezech et al.   BLOOD

Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes

(2014) Kazunori Murai et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Proteasome Proteolysis Supports Stimulated Platelet Function and Thrombosis

(2013) Nilaksh Gupta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of β-catenin stabilization in human platelets

(2013) Sharda Kumari et al.   BIOCHIMIE

Abnormal megakaryocyte development and platelet function in Nbeal2-/- mice

(2013) W. H. A. Kahr et al.   BLOOD

Proplatelet generation in the mouse requires PKC -dependent RhoA inhibition

(2013) G. Gobbi et al.   BLOOD

Chemoproteomic Discovery of AADACL1 as a Regulator of Human Platelet Activation

(2013) Stephen P. Holly et al.   CHEMISTRY & BIOLOGY

Regulatory Role of Proteasome in Determination of Platelet Life Span

(2013) Manasa K. Nayak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet ITAM signaling is critical for vascular integrity in inflammation

(2013) Yacine Boulaftali et al.   JOURNAL OF CLINICAL INVESTIGATION

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation

(2013) Aae Suzuki et al.   PLoS One

Protein degradation systems in platelets

(2013) Bjoern F. Kraemer et al.   THROMBOSIS AND HAEMOSTASIS

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

(2012) Makoto Osada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome

(2012) Andrew M. Hamilton et al.   NEURON

Ubiquitin/proteasome-rich particulate cytoplasmic structures (PaCSs) in the platelets and megakaryocytes of ANKRD26-related thrombocytopenia

(2012) Vittorio Necchi et al.   THROMBOSIS AND HAEMOSTASIS

Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events

(2011) L. Cecchetti et al.   BLOOD

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle

(2011) David M. Smith et al.   CELL

Regulation of proteasome activity in activated human platelets

(2011) Manasa K. Nayak et al.   CELL CALCIUM

Control of neurite outgrowth by RhoA inactivation

(2011) Chan-Young Jeon et al.   JOURNAL OF NEUROCHEMISTRY

Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome

(2011) Walter HA Kahr et al.   NATURE GENETICS

Platelets

(2010) Cara C. Bertozzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Platelets and Megakaryocytes Contain Functional Nuclear Factor-κB

(2009) Sherry L. Spinelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bortezomib paradigm shift in myeloma

(2009) D. J. McConkey   BLOOD

PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids

(2009) J. M. Foulks et al.   BLOOD

Critical role for ERK1/2 in bone marrow and fetal liver–derived primary megakaryocyte differentiation, motility, and proplatelet formation

(2009) Alexandra Mazharian et al.   EXPERIMENTAL HEMATOLOGY

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

(2009) Daniel Ramsköld et al.   PLoS Computational Biology

PS-341 (Bortezomib) inhibits proliferation and induces apoptosis of megakaryoblastic MO7-e cells

(2007) S. Galimberti et al.   LEUKEMIA RESEARCH

Effects of bortezomib on platelet aggregation and ATP release in human platelets, in vitro

(2007) Ferit Avcu et al.   THROMBOSIS RESEARCH