The incredible journey: From megakaryocyte development to platelet formation

Direct visualization of the endomitotic cell cycle in living megakaryocytes: Differential patterns in low and high ploidy cells

(2014) Nicholas Papadantonakis et al.   CELL CYCLE

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

(2013) H. Schachtner et al.   BLOOD

Conditional Knockout of Integrin α2β1 in Murine Megakaryocytes Leads to Reduced Mean Platelet Volume

(2013) David Habart et al.   PLoS One

Generation of Functional Platelets from Canine Induced Pluripotent Stem Cells

(2013) Toshiya Nishimura et al.   STEM CELLS AND DEVELOPMENT

Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation

(2012) Takuya Matsunaga et al.   ANNALS OF HEMATOLOGY

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production

(2012) J. N. Thon et al.   BLOOD

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

(2012) D. Bluteau et al.   BLOOD

VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice

(2012) S. C. Pitchford et al.   BLOOD

Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf

(2012) Y. Ono et al.   BLOOD

Granule exocytosis is required for platelet spreading: differential sorting of  -granules expressing VAMP-7

(2012) C. G. Peters et al.   BLOOD

Platelet secretion is kinetically heterogeneous in an agonist-responsive manner

(2012) D. Jonnalagadda et al.   BLOOD

Administration of nicotinamide does not increase platelet levels in mice

(2012) Iwona M. Konieczna et al.   BLOOD CELLS MOLECULES AND DISEASES

Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes

(2012) Yuan Gao et al.   DEVELOPMENTAL CELL

Single-cell level analysis of megakaryocyte growth and development

(2012) Younes Leysi-Derilou et al.   DIFFERENTIATION

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

(2012) Lin Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimizing megakaryocyte polyploidization by targeting multiple pathways of cytokinesis

(2012) Mauro P. Avanzi et al.   TRANSFUSION

Microtubule and cortical forces determine platelet size during vascular platelet production

(2012) Jonathan N Thon et al.   Nature Communications

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

(2012) Larissa Lordier et al.   Nature Communications

Mean Platelet Volume May Represent a Predictive Parameter for Overall Vascular Mortality and Ischemic Heart Disease

(2011) Georg Slavka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mean Platelet Volume and Integrin Alleles Correlate With Levels of Integrins α IIb β 3 and α 2 β 1 in Acute Coronary Syndrome Patients and Normal Subjects

(2011) Thomas J. Kunicki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet  -granules

(2011) J. Kamykowski et al.   BLOOD

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation

(2011) S. Patel-Hett et al.   BLOOD

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A

(2011) Y. Zhang et al.   BLOOD

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

(2011) Shi-Jiang Lu et al.   CELL RESEARCH

RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts

(2011) Jaime Melendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New gene functions in megakaryopoiesis and platelet formation

(2011) Christian Gieger et al.   NATURE

Megakaryocytes derived from patients with the classical form of Bernard-Soulier syndrome show no ability to extend proplatelets in vitro

(2011) Alessandra Balduini et al.   PLATELETS

Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999–2004

(2010) Jeffrey S. Berger et al.   ATHEROSCLEROSIS

Anucleate platelets generate progeny

(2010) H. Schwertz et al.   BLOOD

The platelet interior revisited: electron tomography reveals tubular  -granule subtypes

(2010) H. van Nispen tot Pannerden et al.   BLOOD

Bone marrow niche-inspired, multiphase expansion of megakaryocytic progenitors with high polyploidization potential

(2010) Swapna Panuganti et al.   CYTOTHERAPY

Functional characterization of hematopoietic stem cells in the spleen

(2010) Yohei Morita et al.   EXPERIMENTAL HEMATOLOGY

New Roles for Cyclin E in Megakaryocytic Polyploidization

(2010) Alexia Eliades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Transient activation ofc-MYCexpression is critical for efficient platelet generation from human induced pluripotent stem cells

(2010) Naoya Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biology and Chemistry of Thrombopoietic Agents

(2010) David J. Kuter   SEMINARS IN HEMATOLOGY

Platelet dose for prophylactic platelet transfusions

(2010) Joan Cid et al.   Expert Review of Hematology

Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim

(2009) D. J. Kuter et al.   BLOOD

Negative regulation of activated  2 integrins during thrombopoiesis

(2009) Z. Zou et al.   BLOOD

Exposure of human megakaryocytes to high shear rates accelerates platelet production

(2009) C. Dunois-Larde et al.   BLOOD

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis

(2009) S. G. CHU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis

(2009) Isabella Pallotta et al.   PLoS One

Mutation of the  1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly

(2008) S. Kunishima et al.   BLOOD

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

(2008) N. Takayama et al.   BLOOD

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

(2008) L. Lordier et al.   BLOOD