Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear FlowSignificance

(2016) Jevgenia Zilberman-Rudenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Minimum wound size for clotting: flowing blood coagulates on a single collagen fiber presenting tissue factor and von Willebrand factor

(2016) Shu Zhu et al.   Integrative Biology

Platelet-targeting thiol reduction sensor detects thiol isomerase activity on activated platelets in mouse and human blood under flow

(2016) S. Zhu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrin, γ′-Fibrinogen, and Transclot Pressure Gradient Control Hemostatic Clot Growth During Human Blood Flow Over a Collagen/Tissue Factor WoundSignificance

(2015) Ryan W. Muthard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow

(2015) S. Zhu et al.   BLOOD

Polyphosphate accelerates factor V activation by factor XIa

(2015) Sharon Choi et al.   THROMBOSIS AND HAEMOSTASIS

A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets

(2014) J. D. Welsh et al.   BLOOD

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

(2014) T. J. Stalker et al.   BLOOD

A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment

(2014) M. Tomaiuolo et al.   BLOOD

Recombinant factor VIIa enhances platelet deposition from flowing haemophilic blood but requires the contact pathway to promote fibrin deposition

(2014) R. Li et al.   HAEMOPHILIA

Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay

(2014) Shu Zhu et al.   THROMBOSIS RESEARCH

Simulation of Intrathrombus Fluid and Solute Transport Using In Vivo Clot Structures with Single Platelet Resolution

(2013) Roman S. Voronov et al.   ANNALS OF BIOMEDICAL ENGINEERING

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

(2013) T. J. Stalker et al.   BLOOD

Microfluidic assay of hemophilic blood clotting: distinct deficits in platelet and fibrin deposition at low factor levels

(2013) T. V. COLACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrin Networks Regulate Protein Transport during Thrombus Development

(2013) Oleg V. Kim et al.   PLoS Computational Biology

Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Direct Observation of von Willebrand Factor Elongation and Fiber Formation on Collagen During Acute Whole Blood Exposure to Pathological Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blood Clot Formation under Flow: The Importance of Factor XI Depends Strongly on Platelet Count

(2012) Aaron L. Fogelson et al.   BIOPHYSICAL JOURNAL

The Influence of Hindered Transport on the Development of Platelet Thrombi Under Flow

(2012) Karin Leiderman et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Oral Direct Factor Xa Inhibitors

(2012) Calvin H. Yeh et al.   CIRCULATION RESEARCH

Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse

(2012) J. D. WELSH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Factor Xa Generation by Computational Modeling: An Additional Discriminator to Thrombin Generation Evaluation

(2012) Kathleen E. Brummel-Ziedins et al.   PLoS One

Thrombin inhibition profiles in healthy individuals and thrombophilic patients

(2012) Ursula Harbrecht et al.   THROMBOSIS AND HAEMOSTASIS

Relipidated Tissue Factor Linked to Collagen Surfaces Potentiates Platelet Adhesion and Fibrin Formation in a Microfluidic Model of Vessel Injury

(2011) Thomas V. Colace et al.   BIOCONJUGATE CHEMISTRY

Polyphosphate is a cofactor for the activation of factor XI by thrombin

(2011) S. H. Choi et al.   BLOOD

Thrombin Flux and Wall Shear Rate Regulate Fibrin Fiber Deposition State during Polymerization under Flow

(2010) K.B. Neeves et al.   BIOPHYSICAL JOURNAL

A Multiscale Model of Venous Thrombus Formation with Surface-Mediated Control of Blood Coagulation Cascade

(2010) Zhiliang Xu et al.   BIOPHYSICAL JOURNAL

Polyphosphate exerts differential effects on blood clotting, depending on polymer size

(2010) S. A. Smith et al.   BLOOD

P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions

(2010) S. F. Maloney et al.   Integrative Biology

Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood

(2010) Manash S. Chatterjee et al.   PLoS Computational Biology

Factor XI contributes to thrombin generation in the absence of factor XII

(2009) D. V. Kravtsov et al.   BLOOD

Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms

(2009) C. Duckers et al.   BLOOD

Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

(2008) U. M. Okorie et al.   BLOOD

Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates

(2008) K. B. NEEVES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS