Animal models of multiple sclerosis: From rodents to zebrafish

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector

(2017) Atsushi Hamana et al.   MOLECULAR PHARMACEUTICS

Early regional cuprizone-induced demyelination in a rat model revealed with MRI

(2017) Wendy Oakden et al.   NMR IN BIOMEDICINE

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis

(2017) Pushkar Kulkarni et al.   Multiple Sclerosis and Related Disorders

Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber

(2017) Marja J. Karttunen et al.   PLoS One

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release

(2016) Sigrid Koudelka et al.   CURRENT BIOLOGY

Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences

(2016) Silvia M. Tietz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

(2016) Laura A. N. Peferoen et al.   IMMUNOLOGY

Aging and multiple sclerosis

(2016) Shaik Ahmed Sanai et al.   Multiple Sclerosis Journal

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging and multiple sclerosis

(2016) Shaik Ahmed Sanai et al.   Multiple Sclerosis Journal

Oligodendrocyte Development in the Absence of Their Target Axons In Vivo

(2016) Rafael Almeida et al.   PLoS One

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

(2015) Brandon D. Coder et al.   JOURNAL OF IMMUNOLOGY

Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis

(2015) Michael J. Turner et al.   JOURNAL OF NEUROIMMUNOLOGY

Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of Demyelination

(2015)   MOLECULES AND CELLS

Natalizumab analogon therapy is effective in a B cell-dependent multiple sclerosis model

(2015) Darius Häusler et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Fast Progression of Recombinant Human Myelin/Oligodendrocyte Glycoprotein (MOG)-Induced Experimental Autoimmune Encephalomyelitis in Marmosets Is Associated with the Activation of MOG34-56-Specific Cytotoxic T Cells

(2014) Y. S. Kap et al.   JOURNAL OF IMMUNOLOGY

Tournay's description of anisocoria on lateral gaze: Reaction, myth, or phenomenon?

(2014) M. P. Robert et al.   NEUROLOGY

Zebrafish regenerate full thickness optic nerve myelin after demyelination, but this fails with increasing age

(2014) Eva Jolanda Münzel et al.   Acta Neuropathologica Communications

Altered cognitive-emotional behavior in early experimental autoimmune encephalitis – Cytokine and hormonal correlates

(2013) Shaona Acharjee et al.   BRAIN BEHAVIOR AND IMMUNITY

Axonal selection and myelin sheath generation in the central nervous system

(2013) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity

(2013) Deetje Hertzenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Changes in nociceptive sensitivity and object recognition in experimental autoimmune encephalomyelitis (EAE)

(2013) Camille J. Olechowski et al.   EXPERIMENTAL NEUROLOGY

Cladribine interferes with IL-1β synaptic effects in experimental multiple sclerosis

(2013) Alessandra Musella et al.   JOURNAL OF NEUROIMMUNOLOGY

Generation of demyelination models by targeted ablation of oligodendrocytes in the zebrafish CNS

(2013) Ah-Young Chung et al.   MOLECULES AND CELLS

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

Teriflunomide Attenuates Immunopathological Changes in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis

(2013) Garth E. Ringheim et al.   Frontiers in Neurology

Early interneuron dysfunction in ALS: Insights from a mutantsod1zebrafish model

(2012) Alexander McGown et al.   ANNALS OF NEUROLOGY

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis

(2011) Sarah Al-Izki et al.   Multiple Sclerosis Journal

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse

(2011) Sarah Al-Izki et al.   Multiple Sclerosis and Related Disorders

Mouse models for multiple sclerosis: Historical facts and future implications

(2010) Andrew L. Croxford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Control of immune-mediated disease of the central nervous system requires the use of a neuroactive agent: elucidation by the action of mitoxantrone

(2010) D. BAKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of brain lesions in a mouse model of progressive multiple sclerosis

(2010) H. Levy et al.   EXPERIMENTAL NEUROLOGY

Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity

(2010) Jennifer L. Berard et al.   GLIA

A rotarod test for evaluation of motor skill learning

(2010) Hiromi Shiotsuki et al.   JOURNAL OF NEUROSCIENCE METHODS

Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE

(2010) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Interferon-β is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis

(2010) CL Galligan et al.   Multiple Sclerosis Journal

Improving the translational hit of experimental treatments in multiple sclerosis

(2010) Hanna M Vesterinen et al.   Multiple Sclerosis Journal

Exploring the roles of CD8+ T lymphocytes in the pathogenesis of autoimmune demyelination

(2010) Trina A. Johnson et al.   Seminars in Immunopathology

SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination

(2009) Lorelei C. Taylor et al.   BRAIN PATHOLOGY

EAE: An immunologist's magic eye

(2009) Gurumoorthy Krishnamoorthy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

(2009) Bernadette Pöllinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development

(2009) Yolanda S. Kap et al.   Journal of Neuroimmune Pharmacology

Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis

(2009) Jean E. Merrill et al.   JOURNAL OF NEUROLOGY

Clinical, Pathological, and Immunologic Aspects of the Multiple Sclerosis Model in Common Marmosets (Callithrix jacchus)

(2009) Bert A. 't Hart et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Quantification of Myelin and Axon Pathology During Relapsing Progressive Experimental Autoimmune Encephalomyelitis in the Biozzi ABH Mouse

(2009) Samuel J. Jackson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evaluating potential therapies for bladder dysfunction in a mouse model of multiple sclerosis with high-resolution ultrasonography

(2009) S Al-Izki et al.   Multiple Sclerosis Journal

NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora

(2008) Hiroaki Yokote et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis

(2008) Jason R. Lees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Features and Functions of Oligodendrocytes and Myelin Proteins of Lower Vertebrate Species

(2008) Gunnar Jeserich et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss

(2008) David W. Hampton et al.   JOURNAL OF NEUROIMMUNOLOGY

Behavioral and pathological outcomes in MOG 35–55 experimental autoimmune encephalomyelitis

(2008) M.V. Jones et al.   JOURNAL OF NEUROIMMUNOLOGY

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination

(2008) Jean E Merrill   NEUROPSYCHOPHARMACOLOGY

Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)

(2008) Camille J. Olechowski et al.   PAIN