Molecular stretching modulates mechanosensing pathways

The role of focal adhesion anchoring domains of CAS in mechanotransduction

(2017) Jaroslav Braniš et al.   Scientific Reports

Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

(2016) Rishita Changede et al.   BIOESSAYS

Talin2-mediated traction force drives matrix degradation and cell invasion

(2016) Lei Qi et al.   JOURNAL OF CELL SCIENCE

Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy

(2016) Xian Hu et al.   NANO LETTERS

Mechanosensing Controlled Directly by Tyrosine Kinases

(2016) Bo Yang et al.   NANO LETTERS

Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

(2016) Naotaka Nakazawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Converging and Unique Mechanisms of Mechanotransduction at Adhesion Sites

(2016) Mitchell K.L. Han et al.   TRENDS IN CELL BIOLOGY

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network

(2016) Weiwei Luo et al.   PLoS One

Titin Domains Progressively Unfolded by Force Are Homogenously Distributed along the Molecule

(2015) Pasquale Bianco et al.   BIOPHYSICAL JOURNAL

Rap1 and its effector RIAM are required for lymphocyte trafficking

(2015) W. Su et al.   BLOOD

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired  2 integrin function in mice

(2015) S. Klapproth et al.   BLOOD

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

(2015) Rishita Changede et al.   DEVELOPMENTAL CELL

Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures

(2015) Mingxi Yao et al.   Integrative Biology

The mechanotransduction machinery at work at adherens junctions

(2015) B. Ladoux et al.   Integrative Biology

Cellular chirality arising from the self-organization of the actin cytoskeleton

(2015) Yee Han Tee et al.   NATURE CELL BIOLOGY

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

(2015) Haguy Wolfenson et al.   NATURE CELL BIOLOGY

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

(2015) Kristopher E. Kubow et al.   Nature Communications

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Membrane tension and peripheral protein density mediate membrane shape transitions

(2015) Zheng Shi et al.   Nature Communications

Mechanism of Focal Adhesion Kinase Mechanosensing

(2015) Jing Zhou et al.   PLoS Computational Biology

Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions

(2014) Hiroaki Hirata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events

(2014) Haguy Wolfenson et al.   BIOPHYSICAL JOURNAL

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

(2014) Jie Yan et al.   Cellular and Molecular Bioengineering

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

(2014) J-K Jin et al.   ONCOGENE

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

(2014) Jun Yang et al.   Nature Communications

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol

(2014) Jan-Erik Hoffmann et al.   eLife

Mechanisms of talin-dependent integrin signaling and crosstalk

(2013) Mitali Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics

(2013) Radoslav Janoštiak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Strengths and Weaknesses of Recently Engineered Red Fluorescent Proteins Evaluated in Live Cells Using Fluorescence Correlation Spectroscopy

(2013) Amanda Siegel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadherin adhesome at a glance

(2013) R. Zaidel-Bar   JOURNAL OF CELL SCIENCE

Dedicator of Cytokinesis 8 Interacts with Talin and Wiskott-Aldrich Syndrome Protein To Regulate NK Cell Cytotoxicity

(2013) H. Ham et al.   JOURNAL OF IMMUNOLOGY

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

Sharing the force

(2013) Andreas R. Bausch et al.   NATURE MATERIALS

Molecular mechanisms of cellular mechanosensing

(2013) Tianzhi Luo et al.   NATURE MATERIALS

Differential Effect of Actomyosin Relaxation on the Dynamic Properties of Focal Adhesion Proteins

(2013) Irena Lavelin et al.   PLoS One

Snap-, CLIP- and Halo-Tag Labelling of Budding Yeast Cells

(2013) Franziska Stagge et al.   PLoS One

Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function

(2013) Hu Chen et al.   Scientific Reports

Patterning Methods for Polymers in Cell and Tissue Engineering

(2012) Hong Nam Kim et al.   ANNALS OF BIOMEDICAL ENGINEERING

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

(2012) Emmanuel Debrand et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Subcellular Localization of Talin Is Regulated by Inter-domain Interactions

(2012) Asoka Banno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells

(2012) Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Second-Generation Covalent TMP-Tag for Live Cell Imaging

(2012) Zhixing Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane

(2012) Milos Galic et al.   NATURE CELL BIOLOGY

Focal Adhesion Kinase Plays a Role in Osteoblast Mechanotransduction In Vitro but Does Not Affect Load-Induced Bone Formation In Vivo

(2012) Alesha B. Castillo et al.   PLoS One

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

(2012) E. von Castelmur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations

(2012) Brian R. Anderson et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Improved High-Force Magnetic Tweezers for Stretching and Refolding of Proteins and Short DNA

(2011) Hu Chen et al.   BIOPHYSICAL JOURNAL

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

(2011) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

Bayesian localization microscopy reveals nanoscale podosome dynamics

(2011) Susan Cox et al.   NATURE METHODS

DAOSTORM: an algorithm for high- density super-resolution microscopy

(2011) Seamus J Holden et al.   NATURE METHODS

Cytoskeletal protein kinases: titin and its relations in mechanosensing

(2011) Mathias Gautel   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Quantitative Photo Activated Localization Microscopy: Unraveling the Effects of Photoblinking

(2011) Paolo Annibale et al.   PLoS One

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

(2011) N. C. Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

A Molecular Dynamics Investigation of Vinculin Activation

(2010) Javad Golji et al.   BIOPHYSICAL JOURNAL

Force generated by actomyosin contraction builds bridges between adhesive contacts

(2010) Olivier M Rossier et al.   EMBO JOURNAL

Vinculin, an adapter protein in control of cell adhesion signalling

(2010) Alex Carisey et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Dynamics and Mechanism of p130Cas Localization to Focal Adhesions

(2010) Dominique M. Donato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Mechanobiology

(2010) C. T. Lim et al.   Journal of the Royal Society Interface

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Live-cell dSTORM with SNAP-tag fusion proteins

(2010) Teresa Klein et al.   NATURE METHODS

Fluorescent labeling of tetracysteine-tagged proteins in intact cells

(2010) Carsten Hoffmann et al.   Nature Protocols

Achieving increased resolution and more pixels with Superresolution Optical Fluctuation Imaging (SOFI)

(2010) Thomas Dertinger et al.   OPTICS EXPRESS

Formin-binding proteins: Modulators of formin-dependent actin polymerization

(2009) Pontus Aspenström   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PKC Phosphorylation of Titin’s PEVK Element

(2009) Carlos Hidalgo et al.   CIRCULATION RESEARCH

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

(2009) Viola Vogel et al.   CURRENT OPINION IN CELL BIOLOGY

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

(2009) Emmanuel Debrand et al.   FEBS Journal

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding

(2009) A. M. Goldyn et al.   JOURNAL OF CELL SCIENCE

Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

(2009) J. Colombelli et al.   JOURNAL OF CELL SCIENCE

The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin

(2009) Ulla Pentikäinen et al.   JOURNAL OF MOLECULAR BIOLOGY

Second window for in vivo imaging

(2009) Andrew M. Smith et al.   Nature Nanotechnology

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

(2009) E. Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Investigating complexity of protein–protein interactions in focal adhesions

(2008) Tanmay P. Lele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparing Proteins by Their Unfolding Pattern

(2008) Elias M. Puchner et al.   BIOPHYSICAL JOURNAL

Single-Molecule Force Spectroscopy Reveals a Stepwise Unfolding of Caenorhabditis elegans Giant Protein Kinase Domains

(2008) Dina N. Greene et al.   BIOPHYSICAL JOURNAL

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

(2008) Martina Krüger et al.   CIRCULATION RESEARCH

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid signal transduction in living cells is a unique feature of mechanotransduction

(2008) S. Na et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA