Volume-regulated anion channel—a frenemy within the brain

The identification of a volume-regulated anion channel: an amazing Odyssey

(2015) S. F. Pedersen et al.   Acta Physiologica

The volume-regulated anion channel is formed by LRRC8 heteromers – molecular identification and roles in membrane transport and physiology

(2015) Tobias Stauber   BIOLOGICAL CHEMISTRY

Neurological Counterparts of Hyponatremia: Pathological Mechanisms and Clinical Manifestations

(2015) Manuel Alfredo Podestà et al.   Current Neurology and Neuroscience Reports

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

(2015) R. Planells-Cases et al.   EMBO JOURNAL

Intracellular levels of glutamate in swollen astrocytes are preserved via neurotransmitter reuptake and de novo synthesis: implications for hyponatremia

(2015) Alexandra L. Schober et al.   JOURNAL OF NEUROCHEMISTRY

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

(2015) Andrea Milenkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K-Cl cotransporters, cell volume homeostasis, and neurological disease

(2015) Kristopher T. Kahle et al.   TRENDS IN MOLECULAR MEDICINE

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Pathological Role for Exocytotic Glutamate Release from Astrocytes in Hepatic Encephalopathy

(2014) Vedrana Montana et al.   Current Neuropharmacology

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function

(2014) Lalit Kumar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes

(2014) María C. Hyzinski-García et al.   JOURNAL OF PHYSIOLOGY-LONDON

Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system

(2014) T. Akita et al.   NEUROSCIENCE

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

Electrophysiological Characteristics of Enteric Neurons Isolated from the Immortomouse

(2013) Edward G. Hawkins et al.   DIGESTIVE DISEASES AND SCIENCES

Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures

(2013) Sherry Dadsetan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hepatic encephalopathy: effects of liver failure on brain function

(2013) Vicente Felipo   NATURE REVIEWS NEUROSCIENCE

Propagation of cortical spreading depolarization in the human cortex after malignant stroke

(2013) J. Woitzik et al.   NEUROLOGY

Volume-Sensitive Anion Channels Mediate Osmosensitive Glutathione Release from Rat Thymocytes

(2013) Ravshan Z. Sabirov et al.   PLoS One

LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication

(2012) Federico Abascal et al.   BIOESSAYS

The inhibitor of volume-regulated anion channels DCPIB activates TREK potassium channels in cultured astrocytes

(2012) L Minieri et al.   BRITISH JOURNAL OF PHARMACOLOGY

TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation

(2012) Dong Ho Woo et al.   CELL

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

(2012) Nadia Nabil Haj-Yasein et al.   GLIA

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Peri-infarct flow transients predict outcome in rat focal brain ischemia

(2012) J. Lückl et al.   NEUROSCIENCE

Protease Activated Receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis

(2012) Soo-Jin Oh et al.   Molecular Brain

Factor for Adipocyte Differentiation 158 Gene Disruption Prevents the Body Weight Gain and Insulin Resistance Induced by a High-Fat Diet

(2011) Takahiro Hayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ca2+ Nanodomain-Mediated Component of Swelling-Induced Volume-Sensitive Outwardly Rectifying Anion Current Triggered by Autocrine Action of ATP in Mouse Astrocytes

(2011) Tenpei Akita et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Swelling activated Cl- channels in microglia

(2011) Lyanne C. Schlichter et al.   Channels

Na-K-Cl cotransporter-1 in the mechanism of cell swelling in cultured astrocytes after fluid percussion injury

(2011) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures

(2011) María C. Hyzinski-García et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+nanodomains in mouse astrocytes

(2011) Tenpei Akita et al.   JOURNAL OF PHYSIOLOGY-LONDON

Osmosensory Mechanisms in Cellular and Systemic Volume Regulation

(2011) S. F. Pedersen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Brain Perihematoma Genomic Profile Following Spontaneous Human Intracerebral Hemorrhage

(2011) Anna Rosell et al.   PLoS One

Volume Regulated Anion Channel Currents of Rat Hippocampal Neurons and Their Contribution to Oxygen-and-Glucose Deprivation Induced Neuronal Death

(2011) Huaqiu Zhang et al.   PLoS One

V2 Receptor-Mediated Autocrine Role of Somatodendritic Release of AVP in Rat Vasopressin Neurons Under Hypo-Osmotic Conditions

(2011) K. Sato et al.   Science Signaling

Signaling by Neuronal Swelling

(2011) R. D. Fields   Science Signaling

Carbenoxolone inhibits volume-regulated anion conductance in cultured rat cortical astroglia

(2010) Valentina Benfenati et al.   Channels

The Na–K–Cl cotransporter in the brain edema of acute liver failure

(2010) Arumugam R. Jayakumar et al.   JOURNAL OF HEPATOLOGY

Tamoxifen as an effective neuroprotectant in an endovascular canine model of stroke

(2010) Alan S. Boulos et al.   JOURNAL OF NEUROSURGERY

Receptor regulation of osmolyte homeostasis in neural cells

(2010) Stephen K. Fisher et al.   JOURNAL OF PHYSIOLOGY-LONDON

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte glutamine synthetase: Importance in hyperammonemic syndromes and potential target for therapy

(2010) Saul W. Brusilow et al.   Neurotherapeutics

Channel-Mediated Tonic GABA Release from Glia

(2010) S. Lee et al.   SCIENCE

Nonsynaptic Communication Through ATP Release from Volume-Activated Anion Channels in Axons

(2010) R. D. Fields et al.   Science Signaling

Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells

(2009) Andrew E. Blum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels

(2009) K. A. Poulsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Microglia processes block the spread of damage in the brain and require functional chloride channels

(2009) Dustin J. Hines et al.   GLIA

Chloride channels as drug targets

(2009) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Sorting Out Astrocyte Physiology from Pharmacology

(2008) Todd A. Fiacco et al.   Annual Review of Pharmacology and Toxicology

Expression analysis for inverted effects of serotonin transporter inactivation

(2008) Manabu Ichikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chloride Influx Provokes Lamellipodium Formation in Microglial Cells

(2008) Susanna Zierler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra

(2008) Yonghua Zhang et al.   EXPERIMENTAL NEUROLOGY

Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices andin vivorevealed by two-photon microscopy

(2008) W. Christopher Risher et al.   GLIA

Pharmacological “cross-inhibition” of connexin hemichannels and swelling activated anion channels

(2008) Zu-Cheng Ye et al.   GLIA

Autocrine signaling involved in cell volume regulation: The role of released transmitters and plasma membrane receptors

(2008) Rodrigo Franco et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Two conventional protein kinase C isoforms, α and βI, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes

(2008) Alena Rudkouskaya et al.   JOURNAL OF NEUROCHEMISTRY

Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases

(2008) Timothy J. Harrigan et al.   JOURNAL OF NEUROCHEMISTRY

Central mechanisms of osmosensation and systemic osmoregulation

(2008) Charles W. Bourque   NATURE REVIEWS NEUROSCIENCE

Two Distinct Modes of Hypoosmotic Medium-Induced Release of Excitatory Amino Acids and Taurine in the Rat Brain In Vivo

(2008) Renée E. Haskew-Layton et al.   PLoS One

Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells

(2007) Julien Brillault et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY