A Dual Role of Heme Oxygenase-1 in Cancer Cells

The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets

(2018) Somanathapura K. NaveenKumar et al.   ACS Chemical Biology

Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system

(2018) Olga Mucha et al.   ACTA BIOCHIMICA POLONICA

Low expression of GFI-1 Gene is associated with Panobinostat-resistance in acute myeloid leukemia through influencing the level of HO-1

(2018) Bingqing Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway

(2018) Miao Sui et al.   BIOMEDICINE & PHARMACOTHERAPY

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

(2018) Ling-Chu Chang et al.   CANCER LETTERS

The inhibition of heme oxygenase-1 enhances the chemosensitivity and suppresses the proliferation of pancreatic cancer cells through the SHH signaling pathway

(2018) Liang Han et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

(2018) Khaled Greish et al.   MOLECULES

Heme oxygenase inhibition in cancers: possible tools and targets

(2018) Paulina Podkalicka et al.   Wspolczesna Onkologia-Contemporary Oncology

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

(2018) Valeria Sorrenti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

(2018) Mariapaola Nitti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia

(2017) Loredana Salerno et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis

(2017) Colleen E. Kovacsics et al.   GLIA

Amelioration of Ethanol-Induced Hepatitis by Magnesium Isoglycyrrhizinate through Inhibition of Neutrophil Cell Infiltration and Oxidative Damage

(2017) Yan Wang et al.   MEDIATORS OF INFLAMMATION

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin

(2016) Xin Lv et al.   APOPTOSIS

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

(2016) Karen Heyninck et al.   BIOCHEMICAL PHARMACOLOGY

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Drug-induced hepatotoxicity in cancer patients - implication for treatment

(2016) Bruno Vincenzi et al.   Expert Opinion On Drug Safety

Cardiovascular complications and risk of death in sickle-cell disease

(2016) Mark T Gladwin   LANCET

Evaluation of HO-1 expression, cellular ROS production, cellular proliferation and cellular apoptosis in human esophageal squamous cell carcinoma tumors and cell lines

(2016) QUAN-GUANG REN et al.   ONCOLOGY REPORTS

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

(2016) Daniele Tibullo et al.   Oncotarget

ZnPPIX inhibits peritoneal metastasis of gastric cancer via its antiangiogenic activity

(2015) Fu-tai Shang et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines

(2015) Loredana Salerno et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

HO-1/CO system in tumor growth, angiogenesis and metabolism — Targeting HO-1 as an anti-tumor therapy

(2015) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Knockdown of heme oxygenase-1 promotes apoptosis and autophagy and enhances the cytotoxicity of doxorubicin in breast cancer cells

(2015) XIAO-FENG ZHU et al.   Oncology Letters

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species

(2014) Anusha M. Gopalakrishnan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biliverdin’s regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer

(2014) J Zheng et al.   BRITISH JOURNAL OF CANCER

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

The Expression, Function and Targeting of Haem Oxygenase-1 in Cancer

(2014) Mads Hjortso et al.   CURRENT CANCER DRUG TARGETS

Potential crosstalk of Ca2+-ROS-dependent mechanism involved in apoptosis of Kasumi-1 cells mediated by heme oxygenase-1 small interfering RNA

(2014) SIXI WEI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Iron in multiple sclerosis: roles in neurodegeneration and repair

(2014) Erin Stephenson et al.   Nature Reviews Neurology

Hyperbilirubinemia, hemolysis, and increased bilirubin neurotoxicity

(2014) Michael Kaplan et al.   SEMINARS IN PERINATOLOGY

Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin

(2014) Yang-Sui Liu   WORLD JOURNAL OF GASTROENTEROLOGY

Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

(2014) K A Kang et al.   Cell Death & Disease

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

(2013) Avani R. Vyas et al.   AAPS Journal

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1

(2013) Hye-Kyung Na et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Acute iron overload and oxidative stress in brain

(2013) Natacha E. Piloni et al.   TOXICOLOGY

Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity

(2013) Seema Bansal et al.   Redox Biology

Haem oxygenase-1 overexpression alters intracellular iron distribution

(2012) Lilibeth Lanceta et al.   BIOCHEMICAL JOURNAL

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury

(2012) R. Sugimoto et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

(2012) Y. Gottlieb et al.   HAEMATOLOGICA

Heme Oxygenase-1 Promotes Survival of Renal Cancer Cells through Modulation of Apoptosis- and Autophagy-regulating Molecules

(2012) Pallavi Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloporphyrins – An Update

(2012) Stephanie Schulz et al.   Frontiers in Pharmacology

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit

(2010) Yinghui Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Role of heme oxygenase in preserving vascular bioactive NO

(2010) Hyun-Ock Pae et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors

(2009) Mona N. Rahman et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo

(2009) Philipp Nuhn et al.   Molecular Cancer

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

(2008) Elizabeth L. Mackenzie et al.   ANTIOXIDANTS & REDOX SIGNALING

Ubiquitin–proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway

(2008) Pu-Hua Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

(2008) M Lo et al.   BRITISH JOURNAL OF CANCER

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice

(2008) Gabriele Sass et al.   INTERNATIONAL JOURNAL OF CANCER

Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy

(2008) Lei Shi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS

Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin

(2007) Hak-Ryul Kim et al.   LUNG CANCER