PI3Kinases in Diabetes Mellitus and Its Related Complications

Astilbin inhibits high glucose-induced autophagy and apoptosis through the PI3K/Akt pathway in human proximal tubular epithelial cells

(2018) Fang Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Type 1 Diabetes in Parents and Risk of Attention Deficit/Hyperactivity Disorder in Offspring: A Population-Based Study in Sweden

(2018) Jianguang Ji et al.   DIABETES CARE

Risk of Type 2 Diabetes in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder

(2018) Mu-Hong Chen et al.   JOURNAL OF CLINICAL PSYCHIATRY

TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity

(2018) Nipun Jayachandran et al.   JOURNAL OF IMMUNOLOGY

Inhibition of theα-Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic

(2018) Tao Yang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

(2018) Lynn M. Frydrych et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats

(2018) Siresha Bathina et al.   Lipids in Health and Disease

Spotlight on copanlisib and its potential in the treatment of relapsed/refractory follicular lymphoma: evidence to date

(2018) Felix Mensah et al.   OncoTargets and Therapy

MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway

(2018) Yan Chen et al.   Scientific Reports

Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

(2017) Hua-fu Zhao et al.   Molecular Cancer

Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway

(2017) Zhi-Peng Xu et al.   NEUROCHEMICAL RESEARCH

La inhibición de la PI3Kγ protege contra la miocardiopatía diabética en ratones

(2017) Angelo Maffei et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

(2017) Benoit Bilanges et al.   Nature Communications

VEGF-B promotes recovery of corneal innervations and trophic functions in diabetic mice

(2017) Guohu Di et al.   Scientific Reports

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

(2017) Chang Xia et al.   Journal of Diabetes Research

Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses

(2017) Nikolaos Patsoukis et al.   Frontiers in Immunology

The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD8835, a novel PI3Kα inhibitor

(2017) Juliana Maynard et al.   PLoS One

First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas

(2016) A. Patnaik et al.   ANNALS OF ONCOLOGY

Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway

(2016) Xiang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture

(2016) George L. King et al.   DIABETES

Activation of PPAR-γ reduces HPA axis activity in diabetic rats by up-regulating PI3K expression

(2016) Rafael Carvalho Torres et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The class I phosphoinositide 3-kinases α and β control antiphospholipid antibodies-induced platelet activation

(2016) Pierre-Alexandre Laurent et al.   THROMBOSIS AND HAEMOSTASIS

The use of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kβ/δ inhibitor

(2016) Juliana Maynard et al.   EJNMMI Research

PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

(2016) Jelena Kolic et al.   Molecular Metabolism

Electroacupuncture with high frequency at acupoint ST-36 induces regeneration of lost enteric neurons in diabetic rats via GDNF and PI3K/AKT signal pathway

(2015) Fan Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Lack of kinase-independent activity of PI3K  in locus coeruleus induces ADHD symptoms through increased CREB signaling

(2015) I. D'Andrea et al.   EMBO Molecular Medicine

Exploration of efficacy and bleeding with combined phosphoinositide 3-kinase β inhibition and aspirin in man

(2015) S. Nylander et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

(2015) Laura Braccini et al.   Nature Communications

Phosphoinositide 3-Kinases p110α and p110β Have Differential Roles in Insulin-Like Growth Factor-1–Mediated Akt Phosphorylation and Platelet Priming

(2014) Thomas A. Blair et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy

(2013) Michelle B. Hookham et al.   FEBS Journal

Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes

(2012) Paul J Hale et al.   BMC Systems Biology

Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3K -Akt-AS160 in Skeletal Muscle Cells

(2012) C. Osorio-Fuentealba et al.   DIABETES

Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor

(2012) S. NYLANDER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism

(2011) Daniela Carnevale et al.   CARDIOVASCULAR RESEARCH

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Loss of Cardiac Phosphoinositide 3-Kinase p110α Results in Contractile Dysfunction

(2009) Zhongju Lu et al.   CIRCULATION

Signaling cascade of insulin-induced stimulation of l-dopa uptake in renal proximal tubule cells

(2008) Andrea Carranza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes

(2008) Anne Fougerat et al.   CIRCULATION