Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

Obesity Pathogenesis: An Endocrine Society Scientific Statement

(2017) Michael W Schwartz et al.   ENDOCRINE REVIEWS

Metabolic Regulation of the Immune Humoral Response

(2017) Mark Boothby et al.   IMMUNITY

Obesity induces pro-inflammatory B cells and impairs B cell function in old mice

(2017) Daniela Frasca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Costs and Outcomes of Increasing Access to Bariatric Surgery: Cohort Study and Cost-Effectiveness Analysis Using Electronic Health Records

(2017) Martin C. Gulliford et al.   VALUE IN HEALTH

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

(2017) Chang Xia et al.   Journal of Diabetes Research

Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice

(2017) Henriette Frikke-Schmidt et al.   Molecular Metabolism

Diabetes and Sepsis: Risk, Recurrence, and Ruination

(2017) Lynn M. Frydrych et al.   Frontiers in Endocrinology

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Dendritic cells and adipose tissue

(2016) Sandeep Sundara Rajan et al.   IMMUNOLOGY

Human monocytes and macrophages undergo M1-type inflammatory polarization in response to high levels of glucose

(2016) Israel Torres-Castro et al.   IMMUNOLOGY LETTERS

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Local proliferation initiates macrophage accumulation in adipose tissue during obesity

(2016) C Zheng et al.   Cell Death & Disease

Impact of Obesity and Metabolic Syndrome on Immunity

(2016) Catherine J Andersen et al.   Advances in Nutrition

Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2016) Yong-chao Qiao et al.   Journal of Diabetes Research

Chronic Inflammation and γδ T Cells

(2016) Nathan S. Fay et al.   Frontiers in Immunology

Neutrophil functions in morbidly obese subjects

(2015) E. Brotfain et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Decreased NK cell functions in obesity can be reactivated by fat mass reduction

(2015) Janine Jahn et al.   Obesity

Glycemic Control and Mortality in Diabetic Patients Undergoing Dialysis Focusing on the Effects of Age and Dialysis Type: A Prospective Cohort Study in Korea

(2015) Ji In Park et al.   PLoS One

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice

(2014) Pooja Mehta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of T Cells in Malnutrition and Obesity

(2014) Valerie A. Gerriets et al.   Frontiers in Immunology

High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells

(2013) Hao Lu et al.   Cardiovascular Diabetology

Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections

(2013) David Grimaldi et al.   INTENSIVE CARE MEDICINE

Diabetes and its comorbidities—where East meets West

(2013) Alice P. S. Kong et al.   Nature Reviews Endocrinology

Natural Killer Cell Function, an Important Target for Infection and Tumor Protection, Is Impaired in Type 2 Diabetes

(2013) Jeannig Berrou et al.   PLoS One

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Elderly patients may benefit from tight glucose control

(2012) Theresa L. Chin et al.   SURGERY

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

(2011) Chun Zeng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Therapeutic Approaches to Target Inflammation in Type 2 Diabetes

(2010) A. B. Goldfine et al.   CLINICAL CHEMISTRY

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

(2010) M. Jagannathan-Bogdan et al.   JOURNAL OF IMMUNOLOGY

γδ T Cells Are Reduced and Rendered Unresponsive by Hyperglycemia and Chronic TNFα in Mouse Models of Obesity and Metabolic Disease

(2010) Kristen R. Taylor et al.   PLoS One

Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation

(2009) Jeroen Nijhuis et al.   Obesity

The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue

(2009) Bonnie K. Surmi et al.   VASCULAR PHARMACOLOGY

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

(2008) Fabienne Venet et al.   INTENSIVE CARE MEDICINE