Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor

Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

(2012) Jing Ni et al.   Cancer Discovery

Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice

(2011) J. Eileen Bird et al.   THROMBOSIS RESEARCH

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening

(2010) Fabrizio Giordanetto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs

(2010) Olusegun Williams et al.   CHEMISTRY & BIOLOGY

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets

(2009) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of ticagrelor and thienopyridine P2Y12 binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis

(2009) J.J.J. van Giezen et al.   THROMBOSIS RESEARCH

Advantages of a selective β-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat

(2008) Sharelle A. Sturgeon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PTEN-deficient cancers depend on PIK3CB

(2008) S. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling