Investigational drugs for the treatment of osteoarthritis, an update on recent developments

Limonene: Aroma of innovation in health and disease

(2018) A.J. Vieira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain

(2018) Philip G. Conaghan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

(2018) Erik Lindström et al.   Journal of Translational Medicine

Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

(2018) Erik Lindström et al.   Journal of Translational Medicine

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials

(2018) E.E. Vaysbrot et al.   OSTEOARTHRITIS AND CARTILAGE

Safety assessment of vitacoxib: 180-day chronic oral toxicity studies

(2018) Jianzhong Wang et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Serum drug levels of biologic agents in the management of rheumatoid arthritis and spondyloarthritis: a systematic review

(2018) María Martín-López et al.   RHEUMATOLOGY INTERNATIONAL

Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: Results of an extensive critical literature review.

(2018) Emmanuel Maheu et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Strontium ranelate, a promising disease modifying osteoarthritis drug

(2017) Weiyu Han et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bisphosphonate Use and the Risk of Undergoing Total Knee Arthroplasty in Osteoporotic Patients with Osteoarthritis

(2017) Shau-Huai Fu et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

BMP-2 gene activated muscle tissue fragments for osteochondral defect regeneration in the rabbit knee

(2017) Volker M. Betz et al.   JOURNAL OF GENE MEDICINE

Efficacy of celecoxib versus ibuprofen for the treatment of patients with osteoarthritis of the knee: A randomized double-blind, non-inferiority trial

(2017) Ana C Gordo et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial

(2017) Jianping Wang   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Anti-inflammatory effects of polyphenols in arthritis

(2017) Francesca Oliviero et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Resveratrol supplementation reduces pain experience by postmenopausal women

(2017) Rachel H.X. Wong et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways

(2017) Lihua Yu et al.   Molecular Medicine Reports

Efficacy and safety of duloxetine in Chinese patients with chronic pain due to osteoarthritis: a randomized, double-blind, placebo-controlled study

(2017) G. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Fourteen days of etoricoxib 60 mg improves pain, hyperalgesia and physical function in individuals with knee osteoarthritis: a randomized controlled trial

(2017) P. Moss et al.   OSTEOARTHRITIS AND CARTILAGE

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

(2017) C.-Y. Yang et al.   OSTEOARTHRITIS AND CARTILAGE

Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study

(2017) S.X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

(2017) Kentaro Miyamoto et al.   PLoS One

Is osteoarthritis one disease or a collection of many?

(2017) Leticia A Deveza et al.   RHEUMATOLOGY

Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol®) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial

(2017) Melanie Mülek et al.   Nutrients

Long-Term Safety and Efficacy of Fulranumab in Patients With Moderate-to-Severe Osteoarthritis Pain: A Phase II Randomized, Double-Blind, Placebo-Controlled Extension Study

(2017) Panna Sanga et al.   Arthritis & Rheumatology

Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)

(2016) Aya Shiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature

(2016) A. Dell’Isola et al.   BMC MUSCULOSKELETAL DISORDERS

Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial

(2016) Frank W. Roemer et al.   BMC MUSCULOSKELETAL DISORDERS

Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO

(2016) Karel Pavelka et al.   DRUGS & AGING

The single-chain anti-TNF-αantibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis

(2016) Athanasios Tsianakas et al.   EXPERIMENTAL DERMATOLOGY

Monoclonal antibodies for the treatment of osteoarthritis

(2016) Shuang Zheng et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Therapeutic potential of compound K as an IKK inhibitor with implications for osteoarthritis prevention: an in silico and in vitro study

(2016) Sera Kang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain

(2016) John L Hamilton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1α and IL-1β in Healthy Subjects and Patients With Osteoarthritis of the Knee

(2016) Matthew P. Kosloski et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Hand osteoarthritis, menopause and menopausal hormone therapy

(2016) Fiona E. Watt   MATURITAS

Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

(2016) Steven E. Nissen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis

(2016) R.E. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

(2016) S.L. Dunn et al.   OSTEOARTHRITIS AND CARTILAGE

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Cross-Sectional and Longitudinal Associations Between Serum Levels of High-Sensitivity C-Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

(2016) Zhaohua Zhu et al.   ARTHRITIS CARE & RESEARCH

The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway

(2016) Linwei Chen et al.   Scientific Reports

Effects of 18-month treatment with bazedoxifene on enzymatic immature and mature cross-links and non-enzymatic advanced glycation end products, mineralization, and trabecular microarchitecture of vertebra in ovariectomized monkeys

(2015) Mitsuru Saito et al.   BONE

Protective effects of tumor necrosis factor-α blockade by adalimumab on articular cartilage and subchondral bone in a rat model of osteoarthritis

(2015) C.H. Ma et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Possible chondroprotective effect of canakinumab: An in vitro study on human osteoarthritic chondrocytes

(2015) Sara Cheleschi et al.   CYTOKINE

Benefit–Risk Assessment of Diacerein in the Treatment of Osteoarthritis

(2015) Elena Panova et al.   DRUG SAFETY

Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis

(2015) Ana Teresa Rufino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Investigational drugs for the treatment of osteoarthritis

(2015) Kang Wang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β

(2015) Sara Cheleschi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

(2015) Susan E Lacy et al.   mAbs

Drug developers reboot anti-NGF pain programmes

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion

(2015) S. Roberts et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the knee

(2015) J.J. Cherian et al.   OSTEOARTHRITIS AND CARTILAGE

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

(2015) J. Larkin et al.   OSTEOARTHRITIS AND CARTILAGE

Intravenous neridronate in the treatment of acute painful knee osteoarthritis: a randomized controlled study

(2015) Massimo Varenna et al.   RHEUMATOLOGY

Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014

(2015) Felix Eckstein et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Socio-economic costs of osteoarthritis: A systematic review of cost-of-illness studies

(2015) Jaume Puig-Junoy et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects

(2015) Jason M. Gow et al.   ARTHRITIS RESEARCH & THERAPY

A placebo-controlled randomised trial to assess the effect of TGF-ß1-expressing chondrocytes in patients with arthritis of the knee

(2015) M C Lee et al.   Bone & Joint Journal

Brief Report: Intraarticular Sprifermin Not Only Increases Cartilage Thickness, but Also Reduces Cartilage Loss: Location-Independent Post Hoc Analysis Using Magnetic Resonance Imaging

(2015) Felix Eckstein et al.   Arthritis & Rheumatology

Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial

(2014) Yves Henrotin et al.   BMC Complementary and Alternative Medicine

Osteoarthritis joint pain: The cytokine connection

(2014) Rachel E. Miller et al.   CYTOKINE

Normal Activation of Discoidin Domain Receptor 1 Mutants with Disulfide Cross-links, Insertions, or Deletions in the Extracellular Juxtamembrane Region

(2014) Huifang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective estrogen receptor modulators (SERMs): New alternatives for osteoarthritis?

(2014) L. Lugo et al.   MATURITAS

What about strontium ranelate in osteoarthritis? Doubts and securities

(2014) Sara Tenti et al.   Modern Rheumatology

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model

(2014) Daniel J Leong et al.   ARTHRITIS RESEARCH & THERAPY

Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis

(2014) Toshihiro Nagai et al.   ARTHRITIS RESEARCH & THERAPY

Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

(2013) De-gang Yu et al.   ACTA PHARMACOLOGICA SINICA

Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss

(2013) Jean-Pierre Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial

(2013) Takashi Nishii et al.   CLINICAL RHEUMATOLOGY

The Efficacy of Diacerein in Hand Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Study

(2013) Kichul Shin et al.   CLINICAL THERAPEUTICS

New treatments for osteoarthritis

(2013) Elizabeth Smelter et al.   CURRENT OPINION IN RHEUMATOLOGY

Potent inhibitors precise to S1′ loop of MMP-13, a crucial target for osteoarthritis

(2013) Sukesh Kalva et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Preliminary histopathological study of intra-articular injection of a novel highly cross-linked hyaluronic acid in a rabbit model of knee osteoarthritis

(2013) Tommaso Iannitti et al.   JOURNAL OF MOLECULAR HISTOLOGY

Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO2) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

(2013) Y. Henrotin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Use of SERMs for treatment in postmenopausal women

(2013) JoAnn V. Pinkerton et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte

(2013) Yunsheng Ou et al.   MEDICAL SCIENCE MONITOR

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Towards a mechanism-based approach to pain management in osteoarthritis

(2013) Anne-Marie Malfait et al.   Nature Reviews Rheumatology

Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

(2013) R. Chiusaroli et al.   OSTEOARTHRITIS AND CARTILAGE

A phase III placebo- and oxycodone-controlled study of tanezumab in adults with osteoarthritis pain of the hip or knee

(2013) Egilius L.H. Spierings et al.   PAIN

Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy

(2013) Amar S. More et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Disease Progression and Phasic Changes in Gene Expression in a Mouse Model of Osteoarthritis

(2013) Richard F. Loeser et al.   PLoS One

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

(2013) Eleonora Olivotto et al.   PLoS One

Strontium ranelate in the treatment of knee osteoarthritis: new insights and emerging clinical evidence

(2013) Jean-Yves Reginster et al.   Therapeutic Advances in Musculoskeletal Disease

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial

(2012) Laura Louise Laslett et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

(2012) Jean-Yves Reginster et al.   ANNALS OF THE RHEUMATIC DISEASES

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Reaction of platinum anticancer drugs and drug derivatives with a copper transporting protein, Atox1

(2012) Maria E. Palm-Espling et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Efficacy of Infliximab in a Rabbit Model of Osteoarthritis

(2012) Qiankun Zhang et al.   CONNECTIVE TISSUE RESEARCH

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

(2012) C. Cavelti-Weder et al.   DIABETES CARE

Comparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study

(2012) Krishanu Sengupta et al.   International Journal of Medical Sciences

Potential of Raloxifene in reversing osteoarthritis-like alterations in rat chondrocytes: An in vitro model study

(2012) Aysegul Kavas et al.   JOURNAL OF BIOSCIENCES

Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes

(2012) Mireille Bentz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)

(2012) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Unerwünschte Nebenwirkungen von Tapentadol im Vergleich zu Oxycodon

(2012) M. Merker et al.   SCHMERZ

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

(2011) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13

(2011) N.-G. Li et al.   CURRENT MEDICINAL CHEMISTRY

Raloxifene protects cultured human chondrocytes from IL-1β induced damage: A biochemical and morphological study

(2011) Laura Tinti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

(2011) Priyanka Verma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

(2011) Christian Gege et al.   JOURNAL OF MEDICINAL CHEMISTRY

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Pain, catastrophizing and depression in the rheumatic diseases

(2011) Robert R. Edwards et al.   Nature Reviews Rheumatology

Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

(2011) M.I. Menendez et al.   OSTEOARTHRITIS AND CARTILAGE

Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus

(2011) B.C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis subpopulations and implications for clinical trial design

(2011) Sita MA Bierma-Zeinstra et al.   ARTHRITIS RESEARCH & THERAPY

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Canakinumab

(2010) Eugen Dhimolea   mAbs

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identifying the human aggrecanase

(2010) A.J. Fosang et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis

(2010) M. Güler-Yüksel et al.   OSTEOARTHRITIS AND CARTILAGE

Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair

(2010) Toshihiro Nagai et al.   ARTHRITIS RESEARCH & THERAPY

The role of ADAMTSs in arthritis

(2010) Edward A. Lin et al.   Protein & Cell

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial

(2009) Ballari Brahmachari et al.   CLINICAL RHEUMATOLOGY

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

(2009) Dorothea Piecha et al.   INFLAMMATION RESEARCH

Catalytic Domain Architecture of Metzincin Metalloproteases

(2009) F. Xavier Gomis-Rüth   JOURNAL OF BIOLOGICAL CHEMISTRY

Designing the ideal selective estrogen receptor modulator-an achievable goal?

(2009) Hugh S. Taylor   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Osteoarthritis associated with estrogen deficiency

(2009) Jorge A Roman-Blas et al.   ARTHRITIS RESEARCH & THERAPY

Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis

(2009) Christian Barthel et al.   ARTHRITIS RESEARCH & THERAPY

Management of Patients on Nonsteroidal Anti-inflammatory Drugs: A Clinical Practice Recommendation From the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents

(2008) Francis K.L. Chan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

(2008) J-P Raynauld et al.   ANNALS OF THE RHEUMATIC DISEASES

How Close are We to Having Structure-Modifying Drugs Available?

(2008) David J. Hunter et al.   MEDICAL CLINICS OF NORTH AMERICA

Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment – a systematic approach

(2008) Y.H. Sniekers et al.   OSTEOARTHRITIS AND CARTILAGE

Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis

(2008) Peter Cisár et al.   PHYTOTHERAPY RESEARCH

Treatment of osteoarthritis with Pycnogenol®. The SVOS (San Valentino osteo-arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects

(2008) G. Belcaro et al.   PHYTOTHERAPY RESEARCH

The Management of Osteoarthritis: An Overview and Call to Appropriate Conservative Treatment

(2008) David J. Hunter et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip: a systematic review

(2008) B. M. de Klerk et al.   RHEUMATOLOGY

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

(2008) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY

Licofelone: The answer to unmet needs in osteoarthritis therapy?

(2008) Shrinivas K. Kulkarni et al.   Current Rheumatology Reports