ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

(2011) Chris De Savi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors

(2011) Lijie Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors

(2011) Makoto Shiozaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

(2009) Darrin W. Hopper et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

(2009) Micky D. Tortorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms

(2009) Suneel S. Apte   JOURNAL OF BIOLOGICAL CHEMISTRY

N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

(2008) Adam M. Gilbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

(2007) Lidia Mosyak et al.   PROTEIN SCIENCE