Is osteoarthritis one disease or a collection of many?

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Knee osteoarthritis phenotypes and their relevance for outcomes: a systematic review

(2017) L.A. Deveza et al.   OSTEOARTHRITIS AND CARTILAGE

Histopathological subgroups in knee osteoarthritis

(2017) L.A. Wyatt et al.   OSTEOARTHRITIS AND CARTILAGE

Latent Class Analysis in health research

(2017) Alice Kongsted et al.   Journal of Physiotherapy

Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature

(2016) A. Dell’Isola et al.   BMC MUSCULOSKELETAL DISORDERS

Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone

(2016) Marla J. Steinbeck et al.   JOURNAL OF ARTHROPLASTY

A systematic review reveals that the credibility of subgroup claims in low back pain trials was low

(2016) Bruno T. Saragiotto et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

The incident tibiofemoral osteoarthritis with rapid progression phenotype: development and validation of a prognostic prediction rule

(2016) D.L. Riddle et al.   OSTEOARTHRITIS AND CARTILAGE

The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids

(2016) M. van Middelkoop et al.   OSTEOARTHRITIS AND CARTILAGE

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Pain sensitivity profiles in patients with advanced knee osteoarthritis

(2016) Laura A. Frey-Law et al.   PAIN

Patient phenotyping in clinical trials of chronic pain treatments

(2016) Robert R. Edwards et al.   PAIN

Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis

(2016) Josue S. Cardoso et al.   PAIN

Clinical assessment of effusion in knee osteoarthritis—A systematic review

(2016) Nasimah Maricar et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Determination of Pain Phenotypes in Knee Osteoarthritis: A Latent Class Analysis Using Data From the Osteoarthritis Initiative

(2016) Andrew J. Kittelson et al.   ARTHRITIS CARE & RESEARCH

Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis

(2015) Olivier Bruyère et al.   DRUGS & AGING

Cytokines in rheumatoid arthritis — shaping the immunological landscape

(2015) Iain B. McInnes et al.   Nature Reviews Rheumatology

Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort

(2015) M. van der Esch et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammation and intracellular metabolism: new targets in OA

(2015) R. Liu-Bryan   OSTEOARTHRITIS AND CARTILAGE

OA phenotypes, rather than disease stage, drive structural progression – identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Identifying specific profiles in patients with different degrees of painful knee osteoarthritis based on serological biochemical and mechanistic pain biomarkers

(2015) Line Lindhardt Egsgaard et al.   PAIN

Distinct subtypes of knee osteoarthritis: data from the Osteoarthritis Initiative

(2015) Jan H. Waarsing et al.   RHEUMATOLOGY

Three simple rules to ensure reasonably credible subgroup analyses

(2015) James F Burke et al.   BMJ-British Medical Journal

Three simple rules to ensure reasonably credible subgroup analyses

(2015) James F Burke et al.   BMJ-British Medical Journal

Patterns of Coexisting Lesions Detected on Magnetic Resonance Imaging and Relationship to Incident Knee Osteoarthritis: The Multicenter Osteoarthritis Study

(2015) Jingbo Niu et al.   Arthritis & Rheumatology

Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis

(2015) Hikmat N. Daghestani et al.   Arthritis & Rheumatology

The epidemiology of osteoarthritis

(2014) Victoria L. Johnson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

How to Use a Subgroup Analysis

(2014) Xin Sun et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity, metabolic abnormality, and knee osteoarthritis: A cross-sectional study in Korean women

(2014) Sunggun Lee et al.   Modern Rheumatology

The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics

(2014) D.P. Tonge et al.   OSTEOARTHRITIS AND CARTILAGE

Development of a bedside pain assessment kit for the classification of patients with osteoarthritis

(2014) Eric Osgood et al.   RHEUMATOLOGY INTERNATIONAL

Classification of osteoarthritis phenotypes by metabolomics analysis

(2014) Weidong Zhang et al.   BMJ Open

Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities

(2014) Pierre-Régis Burgel et al.   Biomed Research International

Stratified models of care

(2013) Nadine E. Foster et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Structural correlates of pain in joints with osteoarthritis

(2013) D.J. Hunter et al.   OSTEOARTHRITIS AND CARTILAGE

The epidemiology and impact of pain in osteoarthritis

(2013) T. Neogi   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis – a case for personalized health care?

(2013) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Future Directions in Painful Knee Osteoarthritis: Harnessing Complexity in a Heterogeneous Population

(2013) A. J. Kittelson et al.   PHYSICAL THERAPY

Psychological Profiles and Pain Characteristics of Older Adults With Knee Osteoarthritis

(2013) Yenisel Cruz-Almeida et al.   ARTHRITIS CARE & RESEARCH

The Future of Osteoarthritis Therapeutics: Targeted Pharmacological Therapy

(2013) A. Mobasheri   Current Rheumatology Reports

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Management of osteoarthritis of the knee

(2012) K. L. Bennell et al.   BMJ-British Medical Journal

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

(2011) Mukundan Attur et al.   ARTHRITIS AND RHEUMATISM

Prevalence of magnetic resonance imaging-defined atrophic and hypertrophic phenotypes of knee osteoarthritis in a population-based cohort

(2011) Frank W. Roemer et al.   ARTHRITIS AND RHEUMATISM

OARSI-FDA initiative: defining the disease state of osteoarthritis

(2011) N.E. Lane et al.   OSTEOARTHRITIS AND CARTILAGE

Identifying common trajectories of joint space narrowing over two years in knee osteoarthritis

(2011) Susan J. Bartlett et al.   ARTHRITIS CARE & RESEARCH

Identification of phenotypes with different clinical outcomes in knee osteoarthritis: Data from the osteoarthritis initiative

(2011) Jesper Knoop et al.   ARTHRITIS CARE & RESEARCH

Osteoarthritis subpopulations and implications for clinical trial design

(2011) Sita MA Bierma-Zeinstra et al.   ARTHRITIS RESEARCH & THERAPY

Research methods for subgrouping low back pain

(2010) Peter Kent et al.   BMC Medical Research Methodology

Identifying different osteoarthritis phenotypes through epidemiology

(2010) D.T. Felson   OSTEOARTHRITIS AND CARTILAGE

Knee osteoarthritis in obese women with cardiometabolic clustering

(2009) Maryfran Sowers et al.   ARTHRITIS AND RHEUMATISM

Psychosocial factors and the pain experience of osteoarthritis patients: new findings and new directions

(2009) Tamara J Somers et al.   CURRENT OPINION IN RHEUMATOLOGY

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis

(2009) M. Blagojevic et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis associated with estrogen deficiency

(2009) Jorge A Roman-Blas et al.   ARTHRITIS RESEARCH & THERAPY

Developments in the clinical understanding of osteoarthritis

(2009) David T Felson   ARTHRITIS RESEARCH & THERAPY

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET