Hypothalamic Inflammation at a Crossroad of Somatic Diseases

Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity and diabetes: Translational significance

(2018) Md Habibur Rahman et al.   BIOCHEMICAL PHARMACOLOGY

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

Hypothalamic dysfunction in heart failure: pathogenetic mechanisms and therapeutic implications

(2017) Antonios Rigas et al.   HEART FAILURE REVIEWS

Old Maids: Aging and Its Impact on Microglia Function

(2017) Edward Koellhoffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

(2017) Nathalia R. V. Dragano et al.   Journal of Neuroinflammation

Dietary sugars, not lipids, drive hypothalamic inflammation

(2017) Yuanqing Gao et al.   Molecular Metabolism

Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines

(2017) Ophélia Le Thuc et al.   Frontiers in Endocrinology

Neuroinflammatory and autonomic mechanisms in diabetes and hypertension

(2016) Cheng Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

Central leptin resistance and hypothalamic inflammation are involved in letrozole-induced polycystic ovary syndrome rats

(2016) Yuling Lian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation

(2016) Caroline André et al.   DIABETES

MECHANISMS IN ENDOCRINOLOGY: Hypothalamic inflammation and nutrition

(2016) Eliana P Araujo et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Leukemia inhibitory factor as a mediator of lipopolysaccharide effects on appetite and selected hormones and metabolites

(2016) J. A. Daniel et al.   JOURNAL OF ANIMAL SCIENCE

Magnetic resonance imaging of blood–brain barrier permeability in ischemic stroke using diffusion-weighted arterial spin labeling in rats

(2016) Yash V Tiwari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The central role of hypothalamic inflammation in the acute illness response and cachexia

(2016) Kevin G. Burfeind et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypothalamic Inflammation in the Control of Metabolic Function

(2015) Martin Valdearcos et al.   Annual Review of Physiology

60 YEARS OF NEUROENDOCRINOLOGY: The structure of the neuroendocrine hypothalamus: the neuroanatomical legacy of Geoffrey Harris

(2015) Alan G Watts   JOURNAL OF ENDOCRINOLOGY

Factors Associated With Plasma IL-6 Levels During HIV Infection

(2015) Álvaro H. Borges et al.   JOURNAL OF INFECTIOUS DISEASES

Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice

(2015) Licai Cheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation

(2015) K. C. G. de Git et al.   Obesity Reviews

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

(2015) Yizhe Tang et al.   TRENDS IN NEUROSCIENCES

Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders

(2015) Wenjie Lu et al.   Scientific Reports

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

(2015) Karin J. C. Sanders et al.   Journal of Cachexia Sarcopenia and Muscle

Immune aging, dysmetabolism, and inflammation in neurological diseases

(2015) Michela Deleidi et al.   Frontiers in Neuroscience

Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice

(2015) Laura B. Buckman et al.   Molecular Metabolism

Senescent cells: SASPected drivers of age-related pathologies

(2014) Yossi Ovadya et al.   BIOGERONTOLOGY

Leptin Mediates the Increase in Blood Pressure Associated with Obesity

(2014) Stephanie E. Simonds et al.   CELL

Hypothalamic inflammation and the central nervous system control of energy homeostasis

(2014) Gustavo D. Pimentel et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

(2014) Sung S. Choi et al.   PLoS One

Neuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes

(2014) Nathalie Castanon et al.   Frontiers in Endocrinology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter

(2013) X. Shi et al.   DIABETOLOGIA

Whole-brain irradiation increases NREM sleep and hypothalamic expression of IL-1β in rats

(2013) Paola Ballesteros-Zebadua et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

Physiology: Inflammation links ageing to the brain

(2013) Dana Gabuzda et al.   NATURE

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Cooperation between brain and islet in glucose homeostasis and diabetes

(2013) Michael W. Schwartz et al.   NATURE

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Hypothalamic inflammation: a double-edged sword to nutritional diseases

(2012) Dongsheng Cai et al.   Annals of the New York Academy of Sciences

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

(2012) Ana Paula Boroni Moreira et al.   BRITISH JOURNAL OF NUTRITION

Time–Course of Hypothalamic–Pituitary–Adrenal Axis Activity and Inflammation in Juvenile Rat Brain After Cranial Irradiation

(2012) Nataša Veličković et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hypothalamic Astrocytes in Obesity

(2012) Cristina García-Cáceres et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet

(2012) Xiaoke Wang et al.   Experimental Diabetes Research

Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure

(2012) Peng Li et al.   EXPERIMENTAL PHYSIOLOGY

Noninvasive Molecular Imaging of Neuroinflammation

(2012) Andreas H Jacobs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

(2012) Dennys E. Cintra et al.   PLoS One

Cancer cachexia: impact, mechanisms and emerging treatments

(2012) Vanessa C. Vaughan et al.   Journal of Cachexia Sarcopenia and Muscle

125I-Labeled Gold Nanorods for Targeted Imaging of Inflammation

(2011) Xia Shao et al.   ACS Nano

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

(2011) Ana Paula Arruda et al.   ENDOCRINOLOGY

Angiotensin II–Induced Hypertension Is Modulated by Nuclear Factor-κB in the Paraventricular Nucleus

(2011) Jeffrey P. Cardinale et al.   HYPERTENSION

Altered hypothalamic function in diet-induced obesity

(2011) L A Velloso et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis

(2011) Theodore P. Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11C-Ketoprofen Methyl Ester

(2011) M. Shukuri et al.   JOURNAL OF NUCLEAR MEDICINE

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB

(2011) Sudarshana Purkayastha et al.   NATURE MEDICINE

Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

(2011) Fábio S Lira et al.   Nutrition & Metabolism

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptors, inflammation, metabolism and obesity

(2011) Manuel Fresno et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Obesity-Related Hypertension: Epidemiology, Pathophysiology, and Clinical Management

(2010) Theodore A. Kotchen   AMERICAN JOURNAL OF HYPERTENSION

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

(2010) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dietary salt enhances angiotensin-II-induced superoxide formation in the rostral ventrolateral medulla

(2010) Valdir A. Braga   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

Adrenal Responses to Stress

(2010) David S. Goldstein   CELLULAR AND MOLECULAR NEUROBIOLOGY

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

NF-κB Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia

(2010) Pil-Geum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application

(2010) Dorit Trudler et al.   MEDIATORS OF INFLAMMATION

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Computer Models of Stress, Allostasis, and Acute and Chronic Diseases

(2009) David S. Goldstein   Annals of the New York Academy of Sciences

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission Tomography

(2009) Frederic Dolle et al.   CURRENT MEDICINAL CHEMISTRY

Arcuate Nucleus Proopiomelanocortin Neurons Mediate the Acute Anorectic Actions of Leukemia Inhibitory Factor via gp130

(2009) Aaron J. Grossberg et al.   ENDOCRINOLOGY

Sympathetic Actions on the Skeletal Muscle

(2009) Silvestro Roatta et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

(2009) Joshua P. Thaler et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Regulation of Agouti-Related Protein Messenger Ribonucleic Acid Transcription and Peptide Secretion by Acute and Chronic Inflammation

(2008) Jarrad M. Scarlett et al.   ENDOCRINOLOGY

Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation

(2008) Nicolas Arlicot et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

(2008) Fabien Chauveau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Endogenous Melanocortin System Activity Contributes to the Elevated Arterial Pressure in Spontaneously Hypertensive Rats

(2008) Alexandre A. da Silva et al.   HYPERTENSION

Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy

(2008) Srinivas Sriramula et al.   HYPERTENSION

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE