Altered hypothalamic function in diet-induced obesity

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Leptin Receptors on Hypothalamic POMC Neurons Alters Synaptic Inhibition

(2010) Sung Kun Chun et al.   JOURNAL OF NEUROPHYSIOLOGY

Chronic Intermittent Hypoxia Induces NMDA Receptor-Dependent Plasticity and Suppresses Nitric Oxide Signaling in the Mouse Hypothalamic Paraventricular Nucleus

(2010) C. G. Coleman et al.   JOURNAL OF NEUROSCIENCE

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance

(2010) A. A. Pierce et al.   JOURNAL OF NEUROSCIENCE

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Leptin in humans: lessons from translational research

(2009) Susann Blüher et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats

(2009) Lene Jessen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons

(2009) M. Sanchez-Alavez et al.   DIABETES

Functional Role of c-Jun-N-Terminal Kinase in Feeding Regulation

(2009) Elizabeth K. Unger et al.   ENDOCRINOLOGY

Leptin receptor signaling and the regulation of mammalian physiology

(2009) E C Villanueva et al.   INTERNATIONAL JOURNAL OF OBESITY

The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake

(2009) H J Grill et al.   INTERNATIONAL JOURNAL OF OBESITY

Gut peptides in the control of food intake

(2009) T H Moran   INTERNATIONAL JOURNAL OF OBESITY

Health-related quality of life in obese children and adolescents

(2009) M D Tsiros et al.   INTERNATIONAL JOURNAL OF OBESITY

Complications of obesity in children and adolescents

(2009) S R Daniels   INTERNATIONAL JOURNAL OF OBESITY

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

The future of obesity reduction: beyond weight loss

(2009) Robert Ross et al.   Nature Reviews Endocrinology

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Fyn Mediates Leptin Actions in the Thymus of Rodents

(2009) Alessandra Girasol et al.   PLoS One

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

Gastric Banding or Bypass? A Systematic Review Comparing the Two Most Popular Bariatric Procedures

(2008) Jeffrey A. Tice et al.   AMERICAN JOURNAL OF MEDICINE

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR

(2008) Stephen C Woods et al.   Annual Review of Nutrition

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Treatment Modalities of Obesity: What fits whom?

(2008) V. Hainer et al.   DIABETES CARE

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

(2008) Paty Karoll Picardi et al.   ENDOCRINOLOGY

AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus

(2008) Andressa Coope et al.   FEBS LETTERS

Cost-effectiveness of pharmacological anti-obesity treatments: a systematic review

(2008) M Neovius et al.   INTERNATIONAL JOURNAL OF OBESITY

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY