Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Smoking-induced Skeletal Muscle Dysfunction. From Evidence to Mechanisms

(2015) Hans Degens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer

(2015) Ester Puig-Vilanova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy

(2015) C. C. de Theije et al.   JOURNAL OF APPLIED PHYSIOLOGY

The burden of disease in older people and implications for health policy and practice

(2015) Martin J Prince et al.   LANCET

Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials

(2015) José M Garcia et al.   LANCET ONCOLOGY

Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation

(2015) S. E. Jones et al.   THORAX

Chest CT Measures of Muscle and Adipose Tissue in COPD

(2014) Alejandro A. Diaz et al.   ACADEMIC RADIOLOGY

The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men

(2014) Tim Snijders et al.   AGE

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

(2014) Li Zuo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise

(2014) Anthony M. J. Sanchez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

(2014) Cristina Mammucari et al.   Autophagy

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways

(2014) J. Rodriguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Nutrition impact symptoms and body composition in patients with COPD

(2014) J Nordén et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

(2014) Annemie M. Schols et al.   EUROPEAN RESPIRATORY JOURNAL

Anamorelin hydrochloride in the treatment of cancer anorexia-cachexia syndrome

(2014) David C Currow et al.   Future Oncology

Symptom burden in stable COPD patients with moderate or severe airflow limitation

(2014) J. Eckerblad et al.   HEART & LUNG

Nicotine administration in healthy non-smokers reduces appetite but does not alter plasma ghrelin

(2014) Maximilian Pilhatsch et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Principles of Opioid Use in Cancer Pain

(2014) Russell K. Portenoy et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of Anabolic Steroids on Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomised Controlled Trials

(2014) Lei Pan et al.   PLoS One

Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention

(2014) T Deckersbach et al.   Nutrition & Diabetes

Physical Performance and Psychosocial Status in Lung Cancer Patients: Results from a Pilot Study

(2014) Simone Hummler et al.   Oncology Research and Treatment

Satellite cells in human skeletal muscle; from birth to old age

(2013) Lex B. Verdijk et al.   AGE

Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia

(2013) Céline M Op den Kamp et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Clusters of Comorbidities Based on Validated Objective Measurements and Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease

(2013) Lowie E. G. W. Vanfleteren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autophagy in Locomotor Muscles of Patients with Chronic Obstructive Pulmonary Disease

(2013) Yeting Guo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

Nutritional status and disease severity in patients with chronic obstructive pulmonary disease (COPD)

(2013) Haejung Lee et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Autophagic flux and oxidative capacity of skeletal muscles during acute starvation

(2013) Mahroo Mofarrahi et al.   Autophagy

Nutrition as a Metabolic Modulator in COPD

(2013) Annemie M.W.J. Schols   CHEST

Disturbed Intestinal Integrity in Patients With COPD

(2013) Erica P.A. Rutten et al.   CHEST

Quality of dietary intake in relation to body composition in patients with chronic obstructive pulmonary disease eligible for pulmonary rehabilitation

(2013) C van de Bool et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Impact of symptoms of anxiety and depression on COPD Assessment Test scores

(2013) C. W. Hilmarsen et al.   EUROPEAN RESPIRATORY JOURNAL

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease

(2013) R.C.J. Langen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia

(2013) Bram van den Borst et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nucleophagy at a glance

(2013) D. Mijaljica et al.   JOURNAL OF CELL SCIENCE

Acute Dietary Protein Intake Restriction Is Associated with Changes in Myostatin Expression after a Single Bout of Resistance Exercise in Healthy Young Men

(2013) Tim Snijders et al.   JOURNAL OF NUTRITION

Focal psychodynamic therapy, cognitive behaviour therapy, and optimised treatment as usual in outpatients with anorexia nervosa (ANTOP study): randomised controlled trial

(2013) Stephan Zipfel et al.   LANCET

Low physical activity levels and functional decline in individuals with lung cancer

(2013) Catherine L. Granger et al.   LUNG CANCER

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

(2013) E. Lach-Trifilieff et al.   MOLECULAR AND CELLULAR BIOLOGY

Processing of primary and secondary rewards: A quantitative meta-analysis and review of human functional neuroimaging studies

(2013) Guillaume Sescousse et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Brain activity correlated with food preferences: A functional study comparing advanced non-small cell lung cancer patients with and without anorexia

(2013) Karla Sánchez-Lara et al.   NUTRITION

Gastrointestinal Symptoms are Still Prevalent and Negatively Impact Health-Related Quality of Life: A Large Cross-Sectional Population Based Study in The Netherlands

(2013) Merel M. Tielemans et al.   PLoS One

Physical activity level and its clinical correlates in chronic obstructive pulmonary disease: a cross-sectional study

(2013) Mikael Andersson et al.   RESPIRATORY RESEARCH

The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study

(2013) Shrividya Iyer et al.   SUPPORTIVE CARE IN CANCER

Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD

(2013) Despina Constantin et al.   THORAX

Daily physical activity in subjects with newly diagnosed COPD

(2013) Hans Van Remoortel et al.   THORAX

Effects of Ghrelin Treatment on Exercise Capacity in Underweight COPD Patients: a substudy of a multicenter, randomized, double-blind, placebo-controlled trial of ghrelin treatment

(2013) Keisuke Miki et al.   BMC Pulmonary Medicine

The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease

(2012) Bram van den Borst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury–associated Skeletal Muscle Wasting

(2012) D. Clark Files et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NF-κB Activation Is Required for the Transition of Pulmonary Inflammation to Muscle Atrophy

(2012) Ramon C. J. Langen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

Inflammatory and Satellite Cells in the Quadriceps of Patients With COPD and Response to Resistance Training

(2012) Manoj K. Menon et al.   CHEST

Exercise Training Attenuates MuRF-1 Expression in the Skeletal Muscle of Patients With Chronic Heart Failure Independent of Age

(2012) Stephan Gielen et al.   CIRCULATION

Integrative role of neuropeptides and cytokines in cancer anorexia–cachexia syndrome

(2012) Surajeet K. Patra et al.   CLINICA CHIMICA ACTA

Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids

(2012) M.P.K.J. Engelen et al.   CLINICAL NUTRITION

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

Systemic  -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans

(2012) M. J. Vosselman et al.   DIABETES

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

(2012) I. Elias et al.   DIABETES

Daily physical activity after bronchoscopic lung volume reduction: a pilot study: Table 1–

(2012) Jorine E. Hartman et al.   EUROPEAN RESPIRATORY JOURNAL

Does oxidative stress modulate limb muscle atrophy in severe COPD patients?

(2012) Clara Fermoselle et al.   EUROPEAN RESPIRATORY JOURNAL

MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease

(2012) Bruno B. Lemire et al.   JOURNAL OF APPLIED PHYSIOLOGY

The mechanisms of cachexia underlying muscle dysfunction in COPD

(2012) A. H. V. Remels et al.   JOURNAL OF APPLIED PHYSIOLOGY

Loss of quadriceps muscle oxidative phenotype and decreased endurance in patients with mild-to-moderate COPD

(2012) Bram van den Borst et al.   JOURNAL OF APPLIED PHYSIOLOGY

Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD

(2012) Elisabeth APM Romme et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in Chronic Obstructive Pulmonary Disease

(2012) Mariëlle P.K.J. Engelen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Satellite Cells Senescence in Limb Muscle of Severe Patients with COPD

(2012) Marie-Eve Thériault et al.   PLoS One

Two Distinct Chronic Obstructive Pulmonary Disease (COPD) Phenotypes Are Associated with High Risk of Mortality

(2012) Pierre-Régis Burgel et al.   PLoS One

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review article: the role of gastric motility in the control of food intake

(2011) P. Janssen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle

(2011) Marcus Borgenvik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy

(2011) Michael J. Eddins et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Task-Related Oxygen Uptake During Domestic Activities of Daily Life in Patients With COPD and Healthy Elderly Subjects

(2011) Anouk W. Vaes et al.   CHEST

Explained variance for blood gases in a population with COPD

(2011) Eirunn Waatevik Saure et al.   Clinical Respiratory Journal

An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration

(2011) C. Lepper et al.   DEVELOPMENT

Neuropeptide Y and Agouti-Related Peptide Mediate Complementary Functions of Hyperphagia and Reduced Energy Expenditure in Leptin Receptor Deficiency

(2011) Na Luo et al.   ENDOCRINOLOGY

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases

(2011) Mariola J. Edelmann et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

Identification of human gustatory cortex by activation likelihood estimation

(2011) Maria G. Veldhuizen et al.   HUMAN BRAIN MAPPING

Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food

(2011) E. Stice et al.   JOURNAL OF NEUROSCIENCE

Prevalence and Characteristics of Pain in Patients With Chronic Obstructive Pulmonary Disease Compared to the Norwegian General Population

(2011) Signe Berit Bentsen et al.   JOURNAL OF PAIN

Relationship Between Peripheral Muscle Structure and Function in Patients With Chronic Obstructive Pulmonary Disease With Different Nutritional Status

(2011) Carla Malaguti et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

(2011) Yung-Cheng Huang et al.   Lipids in Health and Disease

Resting energy expenditure and protein turnover are increased in patients with severe chronic obstructive pulmonary disease

(2011) Christina C. Kao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program

(2011) Donna L. Murdaugh et al.   NEUROIMAGE

Age-Related Decrease in Cold-Activated Brown Adipose Tissue and Accumulation of Body Fat in Healthy Humans

(2011) Takeshi Yoneshiro et al.   Obesity

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease

(2011) Chun-Rong Ju et al.   RESPIRATORY MEDICINE

Physical activity monitoring in COPD: Compliance and associations with clinical characteristics in a multicenter study

(2011) Benjamin Waschki et al.   RESPIRATORY MEDICINE

Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD

(2011) Amy Lewis et al.   THORAX

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

(2010) Paul Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by tumor necrosis factor-α

(2010) Andrea Bonetto et al.   AMINO ACIDS

Adipose tissue pathways involved in weight loss of cancer cachexia

(2010) I Dahlman et al.   BRITISH JOURNAL OF CANCER

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Respiratory function and the obesity paradox

(2010) Jordan A Guenette et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Quadriceps myostatin expression in COPD

(2010) W. D-C. Man et al.   EUROPEAN RESPIRATORY JOURNAL

Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD

(2010) I. Vogiatzis et al.   EUROPEAN RESPIRATORY JOURNAL

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice

(2010) Siegfried Labeit et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Effects of Different Intensities of Resistance Exercise on Regulators of Myogenesis

(2010) Colin D Wilborn et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Increased postabsorptive and exercise-induced whole-body glucose production in patients with chronic obstructive pulmonary disease

(2010) Frits M.E. Franssen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic Status Regulates Ghrelin Function on Energy Homeostasis

(2010) Dana I. Briggs et al.   NEUROENDOCRINOLOGY

Increased Adipose Tissue Expression of Proinflammatory CD40, MKK4 and JNK in Patients with Very Severe Chronic Obstructive Pulmonary Disease

(2010) Ruzena Tkacova et al.   RESPIRATION

Physiologic limitations during daily life activities in COPD patients

(2010) AJMC Lahaije et al.   RESPIRATORY MEDICINE

Physical inactivity in patients with COPD, a controlled multi-center pilot-study

(2010) Thierry Troosters et al.   RESPIRATORY MEDICINE

Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD

(2010) M. Doucet et al.   THORAX

The impact of sarcopenia and exercise training on skeletal muscle satellite cells

(2009) Tim Snijders et al.   AGEING RESEARCH REVIEWS

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease

(2009) Pamela J. Plant et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effects of Lung Volume Reduction Surgery on Gas Exchange and Breathing Pattern During Maximum Exercise

(2009) Gerard J. Criner et al.   CHEST

Resting energy expenditure and body composition in patients with newly detected cancer

(2009) Dong-xing Cao et al.   CLINICAL NUTRITION

Effects of age, gender and chronic obstructive pulmonary disease on taste acuity

(2009) Laura Wardwell et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Comparative assessment of the quadriceps and the diaphragm in patients with COPD

(2009) Marc-André Caron et al.   JOURNAL OF APPLIED PHYSIOLOGY

Increased serum levels of ghrelin at diagnosis mediate body weight loss in non-small cell lung cancer (NSCLC) patients

(2009) Eleni M. Karapanagiotou et al.   LUNG CANCER

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes

(2009) Fátima Pérez de Heredia et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Plasma ammonia response to incremental cycling and walking tests in COPD

(2009) L.D. Calvert et al.   RESPIRATORY MEDICINE

Physical performance and muscular characteristics in different stages of COPD

(2009) G. Eliason et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Effect of severe calorie restriction on the lung in two strains of mice

(2008) John M. Bishai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Profiling of mRNA Expression in Quadriceps of Patients with COPD and Muscle Wasting

(2008) Richard Debigaré et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

(2008) Micah J Drummond et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Maximal lengthening contractions induce different signaling responses in the type I and type II fibers of human skeletal muscle

(2008) Jörgen Tannerstedt et al.   JOURNAL OF APPLIED PHYSIOLOGY

The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC)

(2008) Eleni M. Karapanagiotou et al.   LUNG CANCER

Elevated Serum Leptin Levels: A Risk Factor for Non-Small-Cell Lung Cancer?

(2008) Agapios Terzidis et al.   ONCOLOGY

Dietary counselling and food fortification in stable COPD: a randomised trial

(2008) C E Weekes et al.   THORAX