Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1

Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis

(2016) Vincent R. Richard et al.   Aging-US

Heterocyclic cyclohexanone monocarbonyl analogs of curcumin can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance

(2015) Jezrael L. Revalde et al.   BIOCHEMICAL PHARMACOLOGY

A liaison between mTOR signaling, ribosome biogenesis and cancer

(2015) Antonio Gentilella et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The role of N-glycan in folding, trafficking and pathogenicity of myelin oligodendrocyte glycoprotein (MOG)

(2015) Joanna Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging

(2015) Hitomi Takada et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand

(2015) A. Lin et al.   CLINICAL CANCER RESEARCH

Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors

(2015) Eunah Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Selective Histone Deacetylase Inhibitors with Anticancer Activity

(2015) Nan Ma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

DNA methylation profiles and biomarkers of oral squamous cell carcinoma

(2015) Yu-Fen Li et al.   Epigenetics

Evaluation of dual P-gp-BCRP inhibitors as nanoparticle formulation

(2015) Manu Smriti Singh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Hypermethylation of ITGA4, TFPI2 and VIMENTIN promoters is increased in inflamed colon tissue: putative risk markers for colitis-associated cancer

(2015) Christian Gerecke et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2)

(2015) Sebastian C. Köhler et al.   JOURNAL OF MEDICINAL CHEMISTRY

New insights into the biology of tissue factor pathway inhibitor

(2015) S. A. Maroney et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

HIF1α Expression under Normoxia in Prostate Cancer— Which Pathways to Target?

(2015) Weranja K.B. Ranasinghe et al.   JOURNAL OF UROLOGY

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

(2015) Mustafa Kinaan et al.   MEDICAL PRINCIPLES AND PRACTICE

Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice

(2015) Jiping Wang et al.   MOLECULAR CARCINOGENESIS

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells

(2015) F Lozupone et al.   ONCOGENE

Pharmacologic Therapy of Diabetes and Overall Cancer Risk and Mortality: A Meta-Analysis of 265 Studies

(2015) Lang Wu et al.   Scientific Reports

Recent Advances in the Use of Metformin: Can Treating Diabetes Prevent Breast Cancer?

(2015) Diana Hatoum et al.   Biomed Research International

Syndecan-3 and TFPI Colocalize on the Surface of Endothelial-, Smooth Muscle-, and Cancer Cells

(2015) Mari Tinholt et al.   PLoS One

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab

(2015) Gerald S. Falchook et al.   Oncotarget

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

(2015) Nicole M. Davis et al.   Oncotarget

Reversal of multidrug resistance in vitro and in vivo by 5-N-formylardeemin, a new ardeemin derivative

(2014) Xuelian Zheng et al.   APOPTOSIS

Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance

(2014) Mafalda Videira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms

(2014) Kathleen A. Wilson-Edell et al.   BREAST CANCER RESEARCH AND TREATMENT

Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma

(2014) Robert J. Motzer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity

(2014) Oliver Ou et al.   CANCER LETTERS

P14ARF Suppresses Tumor-Induced Thrombosis by Regulating the Tissue Factor Pathway

(2014) A. Zerrouqi et al.   CANCER RESEARCH

Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis

(2014) Z. Liu et al.   CLINICAL CANCER RESEARCH

Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell

(2014) Shigekuni Hosogi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

VPA inhibits renal cancer cell migration by targeting HDAC2 and down-regulating HIF-1α

(2014) Feng-qiang Yang et al.   MOLECULAR BIOLOGY REPORTS

Minireview: Challenges and Opportunities in Development of PPAR Agonists

(2014) Matthew B. Wright et al.   MOLECULAR ENDOCRINOLOGY

Drug resistance to targeted therapies: Déjà vu all over again

(2014) Floris H. Groenendijk et al.   Molecular Oncology

Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance

(2014) Nagaraju Anreddy et al.   MOLECULES

An update on PARP inhibitors—moving to the adjuvant setting

(2014) Amir Sonnenblick et al.   Nature Reviews Clinical Oncology

Reversal of doxorubicin resistance by guggulsterone of Commiphora mukul in vivo

(2014) Hong-Bin Xu et al.   PHYTOMEDICINE

TFPI1 Mediates Resistance to Doxorubicin in Breast Cancer Cells by Inducing a Hypoxic-Like Response

(2014) Gerald F. Davies et al.   PLoS One

Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

(2014) Manuela Salerno et al.   PLoS One

Tissue Factor Pathway Inhibitor: Then and Now

(2014) Paul Ellery et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Enhanced shRNA Delivery and ABCG2 Silencing by Charge-Reversible Layered Nanocarriers

(2014) Zhenzhen Chen et al.   Small

Association of ABCB1, β tubulin I, and III with multidrug resistance of MCF7/DOC subline from breast cancer cell line MCF7

(2014) Wentao Li et al.   TUMOR BIOLOGY

Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction

(2014) Hui-Ren Zhou et al.   Toxins

Nucleolar stress with and without p53

(2014) Allison James et al.   Nucleus

Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer

(2014) Kevin M. Schuler et al.   Cancer Medicine

Revisiting the mechanisms of metformin action in the liver

(2013) Benoit Viollet et al.   ANNALES D ENDOCRINOLOGIE

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

(2013) Chloë Daniel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bridging hypoxia, inflammation and estrogen receptors in thyroid cancer progression

(2013) Marco Tafani et al.   BIOMEDICINE & PHARMACOTHERAPY

Chronic lymphocytic leukaemia - the role of the microenvironment pathogenesis and therapy

(2013) Alan D. Ramsay et al.   BRITISH JOURNAL OF HAEMATOLOGY

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors

(2013) Woondong Jeong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function

(2013) Kazuhiro Katayama et al.   CANCER LETTERS

Molecular determinants of trastuzumab efficacy: What is their clinical relevance?

(2013) Pradip De et al.   CANCER TREATMENT REVIEWS

P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives

(2013) Ziyad Binkhathlan et al.   CURRENT CANCER DRUG TARGETS

Do thiazolidinediones still have a role in treatment of type 2 diabetes mellitus?

(2013) A. Consoli et al.   DIABETES OBESITY & METABOLISM

Molecular mechanism of action of metformin: old or new insights?

(2013) Graham Rena et al.   DIABETOLOGIA

Using Multiple Targeted Therapies in Oncology: Considerations for Use, and Progress to Date in Breast Cancer

(2013) Catherine M. Kelly et al.   DRUGS

Role of hypoxia-inducible factors in breast cancer metastasis

(2013) Daniele M Gilkes et al.   Future Oncology

Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance

(2013) Hoin Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The multifaceted activities of AMPK in tumor progression-why the “one size fits all” definition does not fit at all?

(2013) Marcelo G. Bonini et al.   IUBMB LIFE

Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions

(2013) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFPIα and TFPIβ are expressed at the surface of breast cancer cells and inhibit TF-FVIIa activity

(2013) Benedicte Stavik et al.   Journal of Hematology & Oncology

Understanding response and resistance to oestrogen deprivation in ER-positive breast cancer

(2013) N. Patani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo

(2013) Wenwen Chien et al.   MOLECULAR CARCINOGENESIS

Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer- relationship with venous thrombosis risk

(2013) Feras Abu Saadeh et al.   THROMBOSIS RESEARCH

DNA Methylation in Cancer: A Gene Silencing Mechanism and the Clinical Potential of Its Biomarkers

(2013) Shinichi Fukushige et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

An ensemble view of thrombin allostery

(2012) Bernhard C. Lechtenberg et al.   BIOLOGICAL CHEMISTRY

New strategies for targeting the hypoxic tumour microenvironment in breast cancer

(2012) Carol Ward et al.   CANCER TREATMENT REVIEWS

Antiangiogenic agents

(2012) Sarah J. Conley et al.   CELL CYCLE

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies

(2012) Laleh Amiri-Kordestani et al.   DRUG RESISTANCE UPDATES

Drug resistance: Still a daunting challenge to the successful treatment of AML

(2012) Brian C. Shaffer et al.   DRUG RESISTANCE UPDATES

Effective down-regulation of Breast Cancer Resistance Protein (BCRP) by siRNA delivery using lipid-substituted aliphatic polymers

(2012) Hamidreza Montazeri Aliabadi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mitochondrial redox signaling and cancer invasiveness

(2012) Linda Enns et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

p21-activated Kinase-1 Signaling Regulates Transcription of Tissue Factor and Tissue Factor Pathway Inhibitor

(2012) Beatriz Sánchez-Solana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

(2012) Maria Lucia Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Effect of Metformin on Breast Cancer Proliferation in a Randomized Presurgical Trial

(2012) Bernardo Bonanni et al.   JOURNAL OF CLINICAL ONCOLOGY

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects

(2012) M A Pierotti et al.   ONCOGENE

TFPI Alpha and Beta Regulate mRNAs and microRNAs Involved in Cancer Biology and in the Immune System in Breast Cancer Cells

(2012) Benedicte Stavik et al.   PLoS One

Thrombosis and cancer: 40years of research

(2012) Maria Benedetta Donati et al.   THROMBOSIS RESEARCH

Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility

(2011) Benedicte Stavik et al.   BMC CANCER

Direct thrombin inhibitors

(2011) Catherine J. Lee et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Tissue Factor-Activated Coagulation Cascade in the Tumor Microenvironment Is Critical for Tumor Progression and an Effective Target for Therapy

(2011) Y. Liu et al.   CANCER RESEARCH

Knockdown of TFPI-2 promotes migration and invasion of glioma cells

(2011) Florian Gessler et al.   NEUROSCIENCE LETTERS

Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression

(2011) Takeo Nakanishi et al.   Chinese Journal of Cancer

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Epidemiology and pathophysiology of cancer-associated thrombosis

(2010) S Noble et al.   BRITISH JOURNAL OF CANCER

Thromboembolic Complications in Malignant Haematological Disorders

(2010) Roberto Castelli et al.   Current Vascular Pharmacology

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

Inhibition of Histone Deacetylase Attenuates Hypoxia-Induced Migration and Invasion of Cancer Cells via the Restoration of RECK Expression

(2010) H. W. Jeon et al.   MOLECULAR CANCER THERAPEUTICS

Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype

(2010) Anju Singh et al.   MOLECULAR CANCER THERAPEUTICS

Overexpression of both TFPIα and TFPIβ induces apoptosis and expression of genes involved in the death receptor pathway in breast cancer cells

(2010) Benedicte Stavik et al.   MOLECULAR CARCINOGENESIS

Alternatively spliced isoforms of tissue factor pathway inhibitor

(2010) Susan A. Maroney et al.   THROMBOSIS RESEARCH

Reversal of ABC Drug Transporter-Mediated Multidrug Resistance in Cancer Cells: Evaluation of Current Strategies

(2010) Chung-Pu Wu et al.   Current Molecular Pharmacology

Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs

(2009) Yanlin Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Troglitazone inhibits histone deacetylase activity in breast cancer cells

(2009) G.F. Davies et al.   CANCER LETTERS

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

(2009) Henk J. Broxterman et al.   DRUG RESISTANCE UPDATES

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Surviving hypoxia by modulation of mRNA translation rate

(2009) Michael Fähling   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas

(2009) Rolf F. Barth et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of tissue factor pathway inhibitor (TFPI) in human breast and colon cancer tissue

(2009) E. Sierko et al.   THROMBOSIS AND HAEMOSTASIS

Targeting AMPK: A new therapeutic opportunity in breast cancer

(2008) Sirwan M. Hadad et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Vitamin E Analog α -TEA, Methylseleninic Acid, and Trans-Resveratrol in Combination Synergistically Inhibit Human Breast Cancer Cell Growth

(2008) Rachel M. Snyder et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells

(2008) Y-G Yoo et al.   ONCOGENE

Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells

(2008) Robert T. Taylor et al.   TOXICOLOGICAL SCIENCES