Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Fangzhou Ye, Yiran Liang, Yajie Wang, Robert Le Yang, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer is a common malignancy and exosome-mediated communication between cancer-associated fibroblasts (CAFs) and breast cancer cells plays a role in tumor progression. This study identified circTBPL1 as an upregulated circRNA in exosomes derived from CAFs. Transfer of exosomal circTBPL1 from CAFs to breast cancer cells promoted cell proliferation, migration, and invasion. Further investigation revealed that circTBPL1 acts as a sponge for miR-653-5p, leading to increased expression of TPBG and enhanced breast cancer progression. These findings suggest that exosomal circTBPL1 could serve as a biomarker and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Steven He, Rajdeep Chakraborty, Shoba Ranganathan
Summary: Oral cancer is a common type of head and neck squamous cell carcinoma, with a high mortality rate. International research on the molecular pathways of oral cancer has implications for early diagnosis, prognosis, and the development of new drugs. This review focuses on the pathways of proliferation and apoptosis in OSCC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Dayson Moreira, Sagus Sampath, Haejung Won, Seok Voon White, Yu-Lin Su, Marice Alcantara, Chongkai Wang, Peter Lee, Ellie Maghami, Erminia Massarelli, Marcin Kortylewski
Summary: The study suggests that targeted inhibition of STAT3 in tumor-associated myeloid cells enhances the efficacy of radiotherapy against HNSCC by promoting the recruitment of CD8(+) T cells and suppressing tumor growth.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Xiaochen Qi, Quanlin Li, Xiangyu Che, Qifei Wang, Guangzhen Wu
Summary: The development of cancer treatment methods is constantly changing. Precisely inducing specific cell death patterns can potentially provide a more targeted and effective approach for cancer treatment, with minimal collateral damage to normal cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Dennis Schwarz, Marie Lipoldova, Holger Reinecke, Yahya Sohrabi
Summary: This paper provides an overview of the potential mechanisms explaining the anti-inflammatory effects of collagen peptides. It also discusses the possible risks of collagen deposition in inflammatory diseases. Although the detailed mechanisms remain unclear, current knowledge suggests that collagen may be a potential therapeutic option for reducing the residual risk in inflammatory diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Lijun Li, Wenjie You, Xuewen Wang, Yulian Zou, Hong Yao, Hailin Lan, Xinhua Lin, Qiuyu Zhang, Bing Chen
Summary: The study found that the total biflavonoids extract from Selaginella doederleinii (TBESD) and a flavone monomer called Delicaflavone have favorable anti-tumor activity and can restore anti-tumor immune response. TBESD regulates the tumor microenvironment by increasing functional T cells and M1 phenotype TAMs, and decreasing M2 phenotype TAMs, monocytic-MDSCs, and regulatory T cells, thus inhibiting tumor growth.
Article
Nanoscience & Nanotechnology
Qiong Yuan, Benkai Bao, Meiqi Li, Yanli Tang
Summary: This study presents a microenvironment regulation and cellular differentiation strategy for repairing injured nerves. By preparing nanoparticles with bioactive components, the strategy reduces oxidative stress and promotes the proliferation and differentiation of neurons. This combinatorial therapeutic effect improves nerve cell survival and differentiation while enhancing the damaged area's microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Benxia Zhang, Min Hu, Qizhi Ma, Kai Li, Xue Li, Xia He, Pei Shu, Yue Chen, Ge Gao, Diyuan Qin, Fuchun Guo, Jian Zhao, Ning Liu, Kexun Zhou, Mingyang Feng, Weiting Liao, Dan Li, Xin Wang, Yongsheng Wang
Summary: HFRT can improve the major challenge of poor intratumoral infiltration in CAR-T cell therapy for solid tumors by inducing the activation and proliferation of MDSCs in the tumor microenvironment. Therefore, combining HFRT with MDSCs blockade can significantly enhance the intratumoral infiltration and treatment efficacy of CAR-T cells in solid tumor patients.
Review
Biochemistry & Molecular Biology
Lishantini Pearanpan, Fariza Juliana Nordin, Ee Ling Siew, Endang Kumolosasi, Ezanee Azlina Mohamad Hanif, Siti Fathiah Masre, Eng Wee Chua, Hong Sheng Cheng, Nor Fadilah Rajab
Summary: AnxA1 plays an important role in TNBC, being associated with cell migration, epithelial-mesenchymal transition, macrophage polarization, and tumor metastasis and immune landscape. Further experimental studies are needed to investigate the feasibility and effectiveness of targeting AnxA1 for the treatment of TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Benxia Zhang, Min Hu, Qizhi Ma, Kai Li, Xue Li, Xia He, Pei Shu, Yue Chen, Ge Gao, Diyuan Qin, Fuchun Guo, Jian Zhao, Ning Liu, Kexun Zhou, MingYang Feng, Weiting Liao, Dan Li, Xin Wang, Yongsheng Wang
Summary: Poor intratumoral infiltration is a challenge for CAR-T cell therapy in solid tumors. HFRT induces activation and proliferation of tumor-infiltrated MDSCs, mediated by chemokines and receptors. When combined with HFRT, CXCR2 blockade enhances intratumoral infiltration and treatment efficacy of CAR-T cells, promising for CAR-T cell therapy optimization in solid tumors.
Article
Engineering, Biomedical
Lakshmi Kavitha Sthanam, Tanusri Roy, Sejal Patwardhan, Avi Shukla, Shipra Sharma, Pradip Shinde, Hanuman Tulasiram Kale, P. Chandra Shekar, Kiran Kondabagil, Shamik Sen
Summary: Stem cell differentiation is influenced by the interaction between cells and their extracellular matrix, with matrix metalloproteinases (MMPs) playing a role in this process. Differentiation of mouse embryonic stem cells (mESCs) on varying matrices led to changes in MMP expression and activity, affecting integrin expression, mechanotransduction pathways, and germ layer-specific markers. Inhibition of MMP activity altered the germ layer commitment of differentiating mESCs, demonstrating the importance of MMPs in regulating stem cell differentiation.
Article
Oncology
Huanhuan Chen, Keqing Yang, Lingxiao Pang, Jing Fei, Yongliang Zhu, Jianwei Zhou
Summary: This study identified a novel protein, ANKRD22, involved in regulating the immunosuppressive ability of PMN-MDSCs. It was found that ANKRD22 levels were associated with the clinical characteristics and prognosis of ovarian cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Cell Biology
Tatiane P. Pastor, Barbara C. Peixoto, Joao P. B. Viola
Summary: IRF2BP2 is a member of the IRF2BP family of transcriptional regulators, involved in regulating various cellular functions and its imbalance may be related to cancer pathophysiology. Studies have shown its association with hematopoietic and solid tumors through gene fusion and mutations, suggesting a potential role in tumor development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Benjamin Y. Lu, Richa Gupta, Adam Aguirre-Ducler, Nicole Gianino, Hailey Wyatt, Matthew Ribeiro, Veronica L. Chiang, Joseph N. Contessa, Adebowale J. Adeniran, Lucia B. Jilaveanu, Harriet M. Kluger, Kurt A. Schalper, Sarah B. Goldberg
Summary: This study evaluated the composition and functional properties of tumor-infiltrating lymphocytes within brain metastases and primary lung tumors using multiplexed quantitative immunofluorescence. It found that brain metastases had lower T cell infiltration, markers of cytolytic function, and immune regulatory signals compared to primary lung tumors. However, high TIM-3 and LAG-3 expressions in CD3(+) T-cells were associated with longer survival, highlighting unique aspects of the tumor immune microenvironment within the brain.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Emergency Medicine
Sae-Yeon Won, Daniel Dubinski, Thomas Freiman, Volker Seifert, Florian Gessler, Adam Strzelczyk, Juergen Konczalla
Summary: Patients with acute-on-chronic subdural hematoma (acSDH) have a high incidence of acute symptomatic seizures (ASz), which is associated with unfavorable outcomes and high mortality. Prophylactic treatment with antiepileptic drugs should be considered for this specific cohort of patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Clinical Neurology
Bedjan Behmanesh, Florian Gessler, Stephan Duetzmann, Volker Seifert, Lutz Weise, Matthias Setzer
Summary: The study aimed to evaluate the quality of life of patients with spinal infection after surgical and conservative treatment. The results showed that patients who underwent surgery had better quality of life compared to those who received conservative management.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Clinical Neurology
Daniel Dubinski, Sae-Yeon Won, Martin Voss, Fee Keil, Wolfgang Miesbach, Bedjan Behmanesh, Max Dosch, Peter Baumgarten, Joshua D. Bernstock, Volker Seifert, Thomas M. Freiman, Florian Gessler
Summary: GBM patients with postoperative PE showed no significant difference in major intracranial hemorrhage, re-thrombosis, or re-embolism between those receiving DOACs and LMWH. However, a tendency towards reduced mRS at 6 and 12 months was observed in the LMWH cohort, while patients receiving DOACs had a statistical benefit in overall survival. Prospective, randomized trials are needed to further evaluate the use of DOACs for therapeutic anticoagulation in GBM patients with PE.
NEUROSURGICAL REVIEW
(2022)
Article
Emergency Medicine
Daniel Dubinski, Sae-Yeon Won, Fee Keil, Bedjan Behmanesh, Max Dosch, Peter Baumgarten, Joshua D. Bernstock, Volker Seifert, Thomas M. Freiman, Florian Gessler
Summary: Surgery is the preferred treatment for pyogenic spondylodiscitis to prevent complications such as deep vein thrombosis and pulmonary embolism. Risk factors for pulmonary embolism in these patients include coronary heart disease, female sex, anticoagulation at admission, and non-O blood type. Neurosurgery was not found to increase the risk of pulmonary embolism in comparison to conservative treatment.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Sarah E. Blitz, Ari D. Kappel, Florian A. Gessler, Neil V. Klinger, Omar Arnaout, Yi Lu, Pier Paolo Peruzzi, Timothy R. Smith, Ennio A. Chiocca, Gregory K. Friedman, Joshua D. Bernstock
Summary: Oncolytic virotherapy uses viruses to selectively infect malignant cells and stimulate antitumor response. The involvement of tumor-associated macrophage/microglia appears to play a crucial role in the failure of oncolytic virotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Sae-Yeon Won, Daniel Dubinski, Jonas Hagemeier, Bedjan Behmanesh, Svorad Trnovec, Joshua D. Bernstock, Thomas M. Freiman, Florian Gessler
Summary: This study aimed to determine the optimal intracranial pressure monitoring method for infratentorial mass lesions. The systematic review and meta-analysis found that infratentorial lesions lead to significantly higher intracranial pressure in the infratentorial compartment compared to the supratentorial compartment, with a stabilization of pressure after 48 hours.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Sae-Yeon Won, Simon Krieger, Daniel Dubinski, Florian Gessler, Bedjan Behmanesh, Thomas M. Freiman, Juergen Konczalla, Volker Seifert, Sriramya Lapa
Summary: Dysphagia is a common symptom in SDH patients, with surgery being an effective preventive measure for dysphagia. Neurological function score, cardiovascular disease, and pneumonia are independent predictors of dysphagia. Patients with dysphagia show significant improvement under speech and language pathology treatment, but those with severe dysphagia do not show significant improvement.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Daniel Dubinski, Sae-Yeon Won, Bedjan Behmanesh, Max Dosch, Viktoria Puchinin, Peter Baumgarten, Joshua D. Bernstock, Martin Voss, Patrick Schuss, Juergen Konczalla, Marcus Czabanka, Thomas M. Freiman, Florian Gessler
Summary: Therapeutic anticoagulation has a significant impact on the recurrence pattern in GBM patients, leading to an increase in multifocal, midline crossing, and sharp demarcated recurrence patterns. The underlying pathophysiology remains to be elucidated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Andrea Spyrantis, Tirza Woebbecke, Daniel Ruess, Anne Constantinescu, Andreas Gierich, Klaus Luyken, Veerle Visser-Vandewalle, Eva Herrmann, Florian Gessler, Marcus Czabanka, Harald Treuer, Maximilian Ruge, Thomas M. Freiman
Summary: This study compared the mechanical accuracy of the Robotic Surgery Assistant (ROSA) and the Leksell stereotactic frame. The results showed that robotics was significantly more accurate. Procedural factors during surgery may have a more relevant impact on overall accuracy.
FRONTIERS IN NEUROROBOTICS
(2022)
Article
Clinical Neurology
Daniel Dubinski, Sae-Yeon Won, Svorad Trnovec, Kseniya Gounko, Peter Baumgarten, Philipp Warnke, Daniel Cantre, Bedjan Behmanesh, Joshua D. Bernstock, Thomas M. Freiman, Florian Gessler, Steffen Sola
Summary: This study found that recurrent chronic subdural hematoma (CSDH) may be associated with clinically inapparent low-grade infections, with the majority of identified bacteria belonging to the staphylococcus genus.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Joshua D. Bernstock, Samantha E. Hoffman, Ari D. Kappel, Pablo A. Valdes, Walid Ibn Essayed, Neil Klinger, Kyung-Don Kang, Stacie K. Totsch, Hannah E. Olsen, Charles W. Schlappi, Katharina Filipski, Florian A. Gessler, Lissa Baird, Mariella G. Filbin, Rintaro Hashizume, Oren J. Becher, Gregory K. Friedman
Summary: Diffuse midline gliomas (DMG) are highly aggressive and fatal pediatric brain tumors. Traditional treatments have limited effectiveness, making immunotherapy a promising alternative. This review summarizes various immunotherapy-based treatments for DMG and highlights the clinical success of anti-GD2 CAR-T therapy in patients with diffuse intrinsic pontine glioma (DIPG).
Article
Medicine, General & Internal
Fatma Kilinc, Matthias Setzer, Vincent Prinz, Daniel Jussen, Gerhard Marquardt, Florian Gessler, Marcus Czabanka, Thomas Freiman, Daniel Dubinski, Sae-Yeon Won, Moritz Haberland, Bedjan Behmanesh
Summary: In this retrospective study, it was found that preoperative physical activity and physiological body weight were associated with postoperative outcome, quality of life, and early return to work in patients with spinal meningiomas who underwent surgical treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Paramesh Karandikar, Jakob V. E. Gerstl, Ari D. Kappel, Sae-Yeon Won, Daniel Dubinski, Monica Emili Garcia-Segura, Florian A. Gessler, Alfred Pokmeng See, Luca Peruzzotti-Jametti, Joshua D. Bernstock
Summary: The post-translational modifier SUMO plays a significant role in various biological processes, including the stress response in mammals. Its neuroprotective effects have been observed in hibernation torpor of ground squirrels, suggesting its potential as a therapeutic target for acute cerebral ischemia. Recent advances in screening techniques have identified small molecules that can enhance SUMOylation, and these compounds have shown promise in preclinical models of cerebral ischemia. This review summarizes current knowledge and emphasizes the translational potential of the SUMOylation pathway in brain ischemia.
Article
Oncology
Joshua D. Bernstock, Sam E. Gary, Neil Klinger, Pablo A. Valdes, Walid Ibn Essayed, Hannah E. Olsen, Gustavo Chagoya, Galal Elsayed, Daisuke Yamashita, Patrick Schuss, Florian A. Gessler, Pier Paolo Peruzzi, Asim K. Bag, Gregory K. Friedman
Summary: Glioblastoma is the most common primary adult intracranial malignancy with poor prognosis. MRI is crucial for diagnosis, surgical planning, and post-treatment monitoring, but conventional MRI lacks information about tumor microvasculature, necrosis, or angiogenesis. Thus, developing novel imaging technologies is important for disease characterization and therapeutic development.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Medicine, General & Internal
Felix Lehmann, Matthias Schneider, Joshua D. Bernstock, Christian Bode, Valeri Borger, Stefan Felix Ehrentraut, Florian Gessler, Anna-Laura Potthoff, Christian Putensen, Lorena M. Schenk, Julian Zimmermann, Hartmut Vatter, Patrick Schuss, Alexis Hadjiathanasiou
Summary: This retrospective study examined the prevalence of treatment-limiting decisions (TLDs) and factors driving TLDs in patients with spontaneous intracerebral hemorrhage (ICH). The results showed that TLDs were reached in 42% of the patients, with severity of injury and expected outcomes being important factors.
MEDICINA-LITHUANIA
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
