A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors

α-Linolenic acid–derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40

(2018) Ryuji Ohue-Kitano et al.   FASEB JOURNAL

A Phytol-Enriched Diet Activates PPAR-α in the Liver and Brown Adipose Tissue to Ameliorate Obesity-Induced Metabolic Abnormalities

(2018) Ji-Yeong An et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation

(2018) Miguel Moutinho et al.   Annual Review of Pharmacology and Toxicology

Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review

(2018) Muwen Lu et al.   Food & Function

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1

(2017) Minji Kim et al.   FASEB JOURNAL

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

(2017) Tsuyoshi Goto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maturing of the nuclear receptor family

(2017) Mitchell A. Lazar   JOURNAL OF CLINICAL INVESTIGATION

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

(2017) Mari Iwase et al.   LIPIDS

PPARα-ATGL pathway improves muscle mitochondrial metabolism: implication in aging

(2016) Dipsikha Biswas et al.   FASEB JOURNAL

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice

(2016) Aarthi V. Maganti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

(2015) Tsuyoshi Goto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors

(2015) Tsuyoshi GOTO et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Management of obesity: improvement of health-care training and systems for prevention and care

(2015) William H Dietz et al.   LANCET

Patchy progress on obesity prevention: emerging examples, entrenched barriers, and new thinking

(2015) Christina A Roberto et al.   LANCET

9-Oxo-10(E),12(Z),15(Z)-Octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor α in Hepatocytes

(2015) Haruya Takahashi et al.   LIPIDS

Establishing the Role of PPARβ/δ in Carcinogenesis

(2015) Jeffrey M. Peters et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α

(2014) Haruya Takahashi et al.   JOURNAL OF LIPID RESEARCH

13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor γ in Adipocytes

(2014) Haruya Takahashi et al.   LIPIDS

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells

(2013) Rino Kimura et al.   JOURNAL OF LIPID RESEARCH

Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice

(2013) Nobuyuki Takahashi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

(2013) S. Kishino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Bixin Activates PPARα and Improves Obesity-Induced Abnormalities of Carbohydrate and Lipid Metabolism in Mice

(2012) Tsuyoshi Goto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors

(2012) Tsuyoshi Goto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice

(2012) Young-il Kim et al.   PLoS One

Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways

(2011) Tsuyoshi Goto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Isoprenoid is a perfect fit for fat factor: Figure 1

(2011) Andrew J. Brown   BIOCHEMICAL JOURNAL

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist

(2011) Tsuyoshi Goto et al.   BIOCHEMICAL JOURNAL

Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes

(2011) Tsuyoshi Goto et al.   JOURNAL OF LIPID RESEARCH

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity

(2011) Kouji Nomaguchi et al.   Obesity Research & Clinical Practice

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

(2010) Young-Il Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism

(2010) Tsuyoshi Goto et al.   PPAR Research

Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARγ activation

(2009) Nobuyuki Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sorting out the functional role(s) of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer

(2009) Jeffrey M. Peters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

(2009) Manu V. Chakravarthy et al.   CELL

New developments in adipogenesis

(2009) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation

(2008) Min-Sook Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Effect of Synthetic Dietary Triglycerides: A Novel Research Paradigm for Nutrigenomics

(2008) Linda M. Sanderson et al.   PLoS One

Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes

(2007) Kayo Kuroyanagi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR