α-Linolenic acid–derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

(2017) Julia M. Houthuijzen et al.   FASEB JOURNAL

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Free fatty acid G-protein coupled receptor signaling in M1 skewed white adipose tissue macrophages

(2016) Warren Antonio Vieira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages

(2016) Dong-Soon Im   EUROPEAN JOURNAL OF PHARMACOLOGY

Adipose tissue adaptive response to trans-10,cis-12–conjugated linoleic acid engages alternatively activated M2 macrophages

(2016) Maria Pini et al.   FASEB JOURNAL

Enhanced M2 macrophage polarization in high n-3 polyunsaturated fatty acid transgenic mice fed a high-fat diet

(2016) Mi-Young Song et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Microbial metabolite butyrate facilitates M2 macrophage polarization and function

(2016) Jian Ji et al.   Scientific Reports

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

(2015) Tsuyoshi Goto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors

(2015) Carla Sosa-Alvarado et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

(2015) Abishek Iyer et al.   FASEB JOURNAL

G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ)

(2015) Shuibang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization

(2015) Gaetano Zizzo et al.   Journal of Inflammation-London

A novel unsaturated fatty acid hydratase toward C16 to C22 fatty acids fromLactobacillus acidophilus

(2015) Akiko Hirata et al.   JOURNAL OF LIPID RESEARCH

Rosiglitazone inhibition of calvaria-derived osteoblast differentiation is through both of PPARγ and GPR40 and GSK3β-dependent pathway

(2015) Xiao-Lu Tang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

(2015) Minji Kim et al.   Scientific Reports

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

(2014) Yun-Gi Kim et al.   Cell Host & Microbe

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway

(2014) Junki Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

(2014) Yolanda Williams-Bey et al.   PLoS One

Immunomodulatory activity of a gut microbial metabolite of dietary linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, associated with improved antioxidant/detoxifying defences

(2014) Paolo Bergamo et al.   Journal of Functional Foods

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Lactobacillus brevisG-101 ameliorates colitis in mice by inhibiting NF-κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages

(2013) S.-E. Jang et al.   JOURNAL OF APPLIED MICROBIOLOGY

Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor

(2013) Masakatsu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary Oleic Acid Increases M2 Macrophages in the Mesenteric Adipose Tissue

(2013) Christina Camell et al.   PLoS One

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

(2013) S. Kishino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

In Vitro Comparison of the Effects of Probiotic, Commensal and Pathogenic Strains on Macrophage Polarization

(2013) Trine Eker Christoffersen et al.   Probiotics and Antimicrobial Proteins

IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis

(2012) Cathal McCarthy et al.   FASEB JOURNAL

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response

(2012) Laszlo Nagy et al.   PHYSIOLOGICAL REVIEWS

Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis

(2012) Josep Bassaganya-Riera et al.   PLoS One

Changes in lamina propria dendritic cells on the oral administration of exogenous protein antigens during weaning

(2011) Ryuji Ohue et al.   CYTOTECHNOLOGY

Bacterial Heat Shock Protein 60, GroEL, Can Induce the Conversion of Naïve T Cells into a CD4+ CD25+ Foxp3-Expressing Phenotype

(2011) Ryuji Ohue et al.   Journal of Innate Immunity

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice

(2011) Tsuyoshi Goto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

(2008) Cynthia Hong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

(2008) M. Wills-Karp et al.   Science Signaling

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH