10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

(2017) Tsuyoshi Goto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice

(2016) Sébastien M. Labbé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis

(2016) Kana Ohyama et al.   DIABETES

Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue

(2016) Wuping Sun et al.   EMBO REPORTS

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

The Intestinal Microbiota in Metabolic Disease

(2016) Anni Woting et al.   Nutrients

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

(2015) Tsuyoshi Goto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Transient Receptor Potential Vanilloid 3 Channel Suppresses Adipogenesis

(2015) Sin Ying Cheung et al.   ENDOCRINOLOGY

The gut microbiome, diet and links to cardiometabolic and chronic disorders

(2015) Judith Aron-Wisnewsky et al.   Nature Reviews Nephrology

The gut microbiota in human energy homeostasis and obesity

(2015) Michael Rosenbaum et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

(2015) Minji Kim et al.   Scientific Reports

Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs

(2014) Sara L. Morales-Lázaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway

(2014) Junki Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

18F-FDG PET/CT Monitoring of  3 Agonist-Stimulated Brown Adipocyte Recruitment in White Adipose Tissue

(2014) J. W. Park et al.   JOURNAL OF NUCLEAR MEDICINE

Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes

(2014) Sungjae Yoo et al.   MOLECULES

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

(2014) S. O'Neill et al.   Obesity Reviews

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

Nutrition, the gut microbiome and the metabolic syndrome

(2013) Petia Kovatcheva-Datchary et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes

(2013) H. Sacks et al.   DIABETES

Activation of GPR40 as a Therapeutic Target for the Treatment of Type 2 Diabetes

(2013) C. F. Burant   DIABETES CARE

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

(2013) S. Kishino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate

(2012) Kenji Shintaku et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters

(2012) Reilly T. Enos et al.   JOURNAL OF LIPID RESEARCH

Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet

(2012) Yuriko Oi-Kano et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

G protein-coupled receptors for energy metabolites as new therapeutic targets

(2012) Clara C. Blad et al.   NATURE REVIEWS DRUG DISCOVERY

TRP channels, omega-3 fatty acids, and oxidative stress in neurodegeneration: from the cell membrane to intracellular cross-links

(2011) M. Leonelli et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

(2011) Nathalie M. Delzenne et al.   Nature Reviews Endocrinology

Signaling by Sensory Receptors

(2011) D. Julius et al.   Cold Spring Harbor Perspectives in Biology

PPARs: diverse regulators in energy metabolism and metabolic diseases

(2010) Yong-Xu Wang   CELL RESEARCH

Obesity, Metabolic Syndrome, and Microbiota

(2010) Herbert Tilg   JOURNAL OF CLINICAL GASTROENTEROLOGY

Non-Pungent Capsaicin Analogs (Capsinoids) Increase Metabolic Rate and Enhance ThermogenesisviaGastrointestinal TRPV1 in Mice

(2009) Fuminori KAWABATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The gut microbiota modulates host energy and lipid metabolism in mice

(2009) Vidya R. Velagapudi et al.   JOURNAL OF LIPID RESEARCH

Erratum: Metabolic Implications of Dietary Trans-fatty Acids

(2009) Suzanne E. Dorfman et al.   Obesity

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of TRPV1 in diabetes and obesity

(2007) Anish Suri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES