PPARα-ATGL pathway improves muscle mitochondrial metabolism: implication in aging

Cell specific differences in the protein abundances of GAPDH and Na+,K+-ATPase in skeletal muscle from aged individuals

(2016) Victoria L. Wyckelsma et al.   EXPERIMENTAL GERONTOLOGY

Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response

(2016) Katia Aquilano et al.   Oncotarget

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

(2015) Ruth C. R. Meex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice

(2015) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

GAPDH and β-actin protein decreases with aging, making Stain-Free technology a superior loading control in Western blotting of human skeletal muscle

(2015) Andreas Vigelsø et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction

(2014) Kari E. Wong et al.   DIABETES

Mitochondrial energetics is impairedin vivoin aged skeletal muscle

(2013) Gilles Gouspillou et al.   AGING CELL

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity

(2013) M. T. Sitnick et al.   DIABETES

High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

(2013) Pierre-Marie Badin et al.   ENDOCRINOLOGY

Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle

(2013) Thomas J. Alsted et al.   JOURNAL OF PHYSIOLOGY-LONDON

Skeletal muscle aging and the mitochondrion

(2013) Matthew L. Johnson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice

(2012) P. M. Nunes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway

(2012) Wei-Lu Chen et al.   BIOCHEMICAL PHARMACOLOGY

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling

(2012) Sascha Obrowsky et al.   JOURNAL OF LIPID RESEARCH

Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting

(2012) Estíbaliz Castillero et al.   Endocrine Connections

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function

(2011) Martin Picard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

(2010) P. Chakrabarti et al.   DIABETES

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

(2009) Elisabeth Huijsman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fenofibrate Simultaneously Induces Hepatic Fatty Acid Oxidation, Synthesis, and Elongation in Mice

(2009) Maaike H. Oosterveer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids

(2009) Gabriele Schoiswohl et al.   JOURNAL OF LIPID RESEARCH

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity

(2009) Jessica M. Sapiro et al.   JOURNAL OF LIPID RESEARCH

Regulation of mitochondrial biogenesis during myogenesis

(2009) A.H.V. Remels et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolomics of the interaction between PPAR-α and age in the PPAR-α-null mouse

(2009) Helen J Atherton et al.   Molecular Systems Biology

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training

(2008) Thomas J. Alsted et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific

(2008) Johan W. E. Jocken et al.   HISTOCHEMISTRY AND CELL BIOLOGY

PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle

(2007) Lotte Leick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM