Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 366, Issue 1, Pages 219-225Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.11.119
Keywords
auraptene; adipocyte; PPAR; adiponectine; MCP-1; inflammation; metabolic syndrome
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Funding
- National Research Foundation of Korea [R11-1999-057-04002-0, R01-2005-000-10408-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR gamma. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPAR gamma antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPAR gamma activations. The results indicate that auraptene activates PPAR gamma in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities. (c) 2007 Elsevier Inc. All rights reserved.
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