Ubiquitin Regulation: The Histone Modifying Enzyme′s Story

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

(2018) Afua A. Akuffo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Methyltransferase EZH2: A Therapeutic Target for Ovarian Cancer

(2018) Bayley A. Jones et al.   MOLECULAR CANCER THERAPEUTICS

ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer

(2018) Peijing Zhang et al.   Cell Reports

Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer

(2018) Karan Bhuripanyo et al.   Science Advances

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4

(2018) Xin Jin et al.   MOLECULAR CELL

EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?

(2017) Ke-Sin Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell cycle-dependent degradation of the methyltransferase SETD3 attenuates cell proliferation and liver tumorigenesis

(2017) Xiaoqing Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion

(2017) Xin Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron

(2017) Yandong Lai et al.   JOURNAL OF CELL SCIENCE

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

(2017) Xiangpeng Dai et al.   NATURE MEDICINE

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

(2017) Pingzhao Zhang et al.   NATURE MEDICINE

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

(2017) Hana Janouskova et al.   NATURE MEDICINE

Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60

(2017) Feng Wang et al.   PLoS One

Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α

(2017) Masayoshi IIZUKA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

USP21 promotes cell proliferation and metastasis through suppressing EZH2 ubiquitination in bladder carcinoma

(2017) Yong Chen et al.   OncoTargets and Therapy

Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation

(2017) Silvia Consalvi et al.   Nature Communications

Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells

(2017) Jiang Chen et al.   Oncotarget

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1

(2017) Yusuke Hirata et al.   Cell Reports

Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer

(2016) Jingxin Feng et al.   BREAST CANCER RESEARCH AND TREATMENT

A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle

(2016) Nana Zheng et al.   CELL CYCLE

The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer

(2016) Zhongwei Li et al.   CELL DEATH AND DIFFERENTIATION

Structure, function and regulation of jade family PHD finger 1 (JADE1)

(2016) Maria V. Panchenko   GENE

Functional analysis of HBO1 in tumor development and inhibitor screening

(2016) LING-LI GUO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22

(2016) Aidong Zhou et al.   NATURE CELL BIOLOGY

SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing

(2016) Kun Zhu et al.   NUCLEIC ACIDS RESEARCH

Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway

(2016) Lei Yi et al.   ONCOLOGY REPORTS

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

(2016) Duk-Hwa Kwon et al.   Nature Communications

SETD2: an epigenetic modifier with tumor suppressor functionality

(2016) Jun Li et al.   Oncotarget

E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain

(2016) Shengyuan Zeng et al.   Protein & Cell

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

(2016) Liqing Wang et al.   EBioMedicine

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

Deubiquitinating enzymes in cellular signaling and disease regulation

(2015) Pranita Hanpude et al.   IUBMB LIFE

Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling

(2015) Irina Tikhanovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation

(2015) Ryoichi Matsunuma et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Arginine Methyltransferase 1 Methylates Smurf2

(2015) Boksik Cha et al.   MOLECULES AND CELLS

USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

(2015) Z Li et al.   ONCOGENE

E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60

(2015) V K Subbaiah et al.   ONCOGENE

Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression

(2015) David Kozono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beating the odds: BETs in disease

(2015) Chen-Yi Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity

(2015) D Kramer et al.   Cell Death & Disease

A bivalent role of TIP60 histone acetyl transferase in human cancer

(2015) Gaëlle Judes et al.   Epigenomics

SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation

(2015) Zhiwei Wang et al.   Nature Communications

The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

(2015) Hongmei Cui et al.   Nature Communications

The role of the histone demethylase KDM4A in cancer

(2015) Lissania Guerra-Calderas et al.   Cancer Genetics

Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

(2014) Lu Wang et al.   CANCER CELL

Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy

(2014) Dongil Kim et al.   CELLULAR SIGNALLING

Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development

(2014) Xiao Han et al.   MOLECULAR CELL

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation

(2014) A A Sahasrabuddhe et al.   ONCOGENE

Downregulation of Ezh2 methyltransferase by FOXP3: New insight of FOXP3 into chromatin remodeling?

(2013) Zhu Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer

(2013) Hany Onsy Habashy et al.   BREAST CANCER RESEARCH AND TREATMENT

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

(2013) J Ding et al.   BRITISH JOURNAL OF CANCER

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

(2013) W. L. Berry et al.   CANCER RESEARCH

Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers

(2013) Masayoshi Iizuka et al.   CANCER SCIENCE

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

F-box protein substrate recognition

(2013) Bill B. Chen et al.   CELL CYCLE

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

(2013) Luis Valor et al.   CURRENT PHARMACEUTICAL DESIGN

Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

(2013) Yung-Luen Yu et al.   EMBO Molecular Medicine

SCFFbxw15Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation

(2013) Chunbin Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of Tip60 by USP7 Determines the Activity of the p53-Dependent Apoptotic Pathway

(2013) Ashraf Dar et al.   MOLECULAR AND CELLULAR BIOLOGY

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

(2013) Yuan Gao et al.   Nature Communications

The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells

(2013) Yadi Wu et al.   Cell Reports

BRMS1 Suppresses Lung Cancer Metastases through an E3 Ligase Function on Histone Acetyltransferase p300

(2012) Y. Liu et al.   CANCER RESEARCH

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

(2012) D. B. Beck et al.   GENES & DEVELOPMENT

p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair

(2012) Qi-En Wang et al.   NUCLEIC ACIDS RESEARCH

SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail

(2011) Yinliang Yin et al.   CELL CYCLE

Regulation of protein stability by GSK3 mediated phosphorylation

(2011) Chong Xu et al.   CELL CYCLE

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2

(2011) J. Zhang et al.   GENES & DEVELOPMENT

The SKP1-Cul1-F-box and Leucine-rich Repeat Protein 4 (SCF-FbxL4) Ubiquitin Ligase Regulates Lysine Demethylase 4A (KDM4A)/Jumonji Domain-containing 2A (JMJD2A) Protein

(2011) Capucine Van Rechem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Polymerase II Carboxyl-terminal Domain Phosphorylation Regulates Protein Stability of the Set2 Methyltransferase and Histone H3 Di- and Trimethylation at Lysine 36

(2011) Stephen M. Fuchs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

(2011) Stine Jørgensen et al.   JOURNAL OF CELL BIOLOGY

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression

(2010) S. Wu et al.   GENES & DEVELOPMENT

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

(2010) Shinya Hayami et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

(2010) Richard C. Centore et al.   MOLECULAR CELL

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

(2010) Mathieu Tardat et al.   NATURE CELL BIOLOGY

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity

(2009) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

(2009) J. H. Schulte et al.   CANCER RESEARCH

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

(2009) Soyoung Lim et al.   CARCINOGENESIS

Chfr is linked to tumour metastasis through the downregulation of HDAC1

(2009) Young Mi Oh et al.   NATURE CELL BIOLOGY

Histone Deacetylase 2 Is Phosphorylated, Ubiquitinated, and Degraded by Cigarette Smoke

(2008) David Adenuga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of TIP60 by ATF2 Modulates ATM Activation

(2008) Anindita Bhoumik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

(2008) Y. Shima et al.   MOLECULAR AND CELLULAR BIOLOGY

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY