Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer

Integrating Next-Generation Genomic Sequencing and Mass Spectrometry To Estimate Allele-Specific Protein Abundance in Human Brain

(2017) Thomas S. Wingo et al.   JOURNAL OF PROTEOME RESEARCH

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling

(2017) Carmen Dominguez-Brauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

(2017) Xianpeng Liu et al.   Nature Communications

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

(2017) Heather S Comstra et al.   eLife

The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5

(2016) Huan-Tian Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A bacterial genetic selection system for ubiquitylation cascade discovery

(2016) Olga Levin-Kravets et al.   NATURE METHODS

Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase–polyubiquitin-binding domain fusions (ligase traps)

(2016) Kevin G Mark et al.   Nature Protocols

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners

(2015) H. F. O'Connor et al.   EMBO REPORTS

A CHIPotle in physiology and disease

(2015) Indranil Paul et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tumour suppressor TRIM33 targets nuclear β-catenin degradation

(2015) Jianfei Xue et al.   Nature Communications

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

(2014) Yongxing Gong et al.   NATURE GENETICS

Activation of UbcH5c∼Ub Is the Result of a Shift in Interdomain Motions of the Conjugate Bound to U-Box E3 Ligase E4B

(2013) Sarah E. Soss et al.   BIOCHEMISTRY

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

UBE4B Protein Couples Ubiquitination and Sorting Machineries to Enable Epidermal Growth Factor Receptor (EGFR) Degradation

(2013) Natalie Sirisaengtaksin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Cbl, a Ubiquitin E3 Ligase That Targets Active β-Catenin

(2013) Vipul Chitalia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis

(2013) Chao Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCFFBXL17 in NRF2 Activation via BACH1 Repressor Turnover

(2013) Meng-Kwang Marcus Tan et al.   MOLECULAR CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

(2013) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

(2013) L. M. Starita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orthogonal Ubiquitin Transfer through Engineered E1-E2 Cascades for Protein Ubiquitination

(2012) Bo Zhao et al.   CHEMISTRY & BIOLOGY

UBE4B: A Promising Regulatory Molecule in Neuronal Death and Survival

(2012) Rami Zeinab et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator

(2012) Min Zhuang et al.   MOLECULAR CELL

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Ataxin-2 repeat-length variation and neurodegeneration

(2011) O. A. Ross et al.   HUMAN MOLECULAR GENETICS

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

(2011) Mingjin Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

The new landscape of protein ubiquitination

(2011) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

(2010) Takeshi Maruyama et al.   EMBO JOURNAL

Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4

(2010) Robert C. Benirschke et al.   STRUCTURE

Structural and Functional Characterization of the Monomeric U-Box Domain from E4B

(2009) Kyle A. Nordquist et al.   BIOCHEMISTRY

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

(2009) Yifat Merbl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes

(2008) Imsang Lee et al.   CELL

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling

(2008) H.-C. S. Yen et al.   SCIENCE

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

(2008) Zhen Xu et al.   BMC STRUCTURAL BIOLOGY