Journal
IUBMB LIFE
Volume 67, Issue 7, Pages 544-555Publisher
WILEY
DOI: 10.1002/iub.1402
Keywords
ubiquitin-proteasome system; deubiquitinating enzymes; signaling; enzyme mechanisms; neurodegenerative disorders; cysteine proteases
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Protein post-translational modification by ubiquitin represents a complex signaling system that regulates many cellular events including proteostasis to intercellular communications. Deubiquitinating enzymes (DUBs) that specifically disassemble Ub-chains or regulate ubiquitin homeostasis reside as a central component in ubiquitin signaling. Human genome encodes almost 100 DUBs and majority of them are not well characterized. Considerable progress has been made in the understanding of enzymatic mechanism; however, their cellular substrate specificity and regulation are largely unknown. Involvement of DUBs in disease regulation has been depicted since its discovery and several attempts have been made for evaluating DUBs as a drug target. In this review, we have updated briefly a new insight of DUBs activity, their cellular role, disease regulation, and therapeutic potential. (c) 2015 IUBMB Life, 67(7):544-555, 2015
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