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Title
Deubiquitinases in cancer: new functions and therapeutic options
Authors
Keywords
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Journal
ONCOGENE
Volume 31, Issue 19, Pages 2373-2388
Publisher
Springer Nature
Online
2011-10-17
DOI
10.1038/onc.2011.443
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Note: Only part of the references are listed.- Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis
- (2011) H. Sun et al. BLOOD
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- (2011) Min Jung Jang et al. CANCER LETTERS
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- (2011) Benedikt M. Kessler et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- An Emerging Model for BAP1’s Role in Regulating Cell Cycle Progression
- (2011) Ziad M. Eletr et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of Aurora B
- (2011) Renske J. van Leuken et al. CELL CYCLE
- DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors
- (2011) Sajjad Hussain et al. CELL CYCLE
- USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation
- (2011) Y-H Fan et al. CELL DEATH AND DIFFERENTIATION
- Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme
- (2011) K H Oh et al. CELL DEATH AND DIFFERENTIATION
- JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress
- (2011) Juhong Liu et al. EMBO JOURNAL
- T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
- (2011) Jens Staal et al. EMBO JOURNAL
- USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
- (2011) Xinna Zhang et al. EMBO JOURNAL
- Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain
- (2011) Mark P A Luna-Vargas et al. EMBO REPORTS
- USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
- (2011) Jean-Hugues Guervilly et al. HUMAN MOLECULAR GENETICS
- An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling
- (2011) Marie Metzig et al. INTERNATIONAL JOURNAL OF CANCER
- Lys-63-specific Deubiquitination of SDS3 by USP17 Regulates HDAC Activity
- (2011) Suresh Ramakrishna et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Usp18 Regulates Epidermal Growth Factor (EGF) Receptor Expression and Cancer Cell Survival via MicroRNA-7
- (2011) Jason E. Duex et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Eric B. Dammer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Richard E. Gilbert et al. KIDNEY INTERNATIONAL
- The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/ -Catenin Signaling
- (2011) T. T. H. Lui et al. MOLECULAR AND CELLULAR BIOLOGY
- The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination
- (2011) J. Murai et al. MOLECULAR AND CELLULAR BIOLOGY
- Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1
- (2011) C. Zhang et al. MOLECULAR CANCER THERAPEUTICS
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- (2011) XiaoDong Huang et al. MOLECULAR CELL
- USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β
- (2011) Jason L. Parsons et al. MOLECULAR CELL
- The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
- (2011) Kirsten Kuhlbrodt et al. NATURE CELL BIOLOGY
- The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
- (2011) Matthew Bott et al. NATURE GENETICS
- Harnessing synthetic lethal interactions in anticancer drug discovery
- (2011) Denise A. Chan et al. NATURE REVIEWS DRUG DISCOVERY
- Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
- (2011) Domagoj Vucic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma
- (2011) S Kuphal et al. ONCOGENE
- Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours
- (2011) N Rajan et al. ONCOGENE
- Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells
- (2011) Yu Lu et al. PLoS One
- An Atlas of Altered Expression of Deubiquitinating Enzymes in Human Cancer
- (2011) Chiara Luise et al. PLoS One
- Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control
- (2011) M. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteolytic networks in cancer
- (2011) Steven D. Mason et al. TRENDS IN CELL BIOLOGY
- The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
- (2011) Michelle de la Vega et al. Nature Communications
- Proteasome inhibitors in cancer therapy
- (2011) Lisa J. Crawford et al. Journal of Cell Communication and Signaling
- Protease addiction and synthetic lethality in cancer
- (2011) José Freije Frontiers in Oncology
- Characterization of Selective Ubiquitin and Ubiquitin-Like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format
- (2010) Xufan Tian et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
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- (2010) Frédéric Colland BIOCHEMICAL SOCIETY TRANSACTIONS
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- (2010) J. Gao et al. BLOOD
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- (2010) C. McFarlane et al. CANCER RESEARCH
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- (2010) V. Kapuria et al. CANCER RESEARCH
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- (2010) Goedele N Maertens et al. EMBO JOURNAL
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- (2010) S Hussain et al. LEUKEMIA
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- (2010) H. Yu et al. MOLECULAR AND CELLULAR BIOLOGY
- Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl
- (2010) Daniele V.F. Tauriello et al. MOLECULAR CELL
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14
- (2010) Byung-Hoon Lee et al. NATURE
- Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
- (2010) Yaron Pereg et al. NATURE CELL BIOLOGY
- Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase
- (2010) Satpal Virdee et al. Nature Chemical Biology
- Synthetic lethal approaches to breast cancer therapy
- (2010) Farah L. Rehman et al. Nature Reviews Clinical Oncology
- Emerging principles in protease-based drug discovery
- (2010) Marcin Drag et al. NATURE REVIEWS DRUG DISCOVERY
- Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
- (2010) Lynn Bedford et al. NATURE REVIEWS DRUG DISCOVERY
- Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
- (2010) Anja Bremm et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
- (2010) S. A. Forbes et al. NUCLEIC ACIDS RESEARCH
- Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
- (2010) J. W. Harbour et al. SCIENCE
- Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
- (2009) Francisca E. Reyes-Turcu et al. Annual Review of Biochemistry
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- (2009) Mingli Xu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling
- (2009) Lynn Verstrepen et al. BIOCHEMICAL PHARMACOLOGY
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- (2009) U. Novak et al. BLOOD
- TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
- (2009) K. Honma et al. BLOOD
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- (2009) Sirio Dupont et al. CELL
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- (2009) Mathew E. Sowa et al. CELL
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- (2009) Sokol V Todi et al. EMBO JOURNAL
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- (2009) Eric M Cooper et al. EMBO JOURNAL
- Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
- (2009) David Komander et al. EMBO REPORTS
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- (2009) Ami Navon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Gufeng Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36
- (2009) A. Endo et al. JOURNAL OF CELL SCIENCE
- The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway
- (2009) Bin Zhao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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- (2009) Ramin Massoumi et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2009) Xiaohua Huang et al. JOURNAL OF MOLECULAR BIOLOGY
- NF-κB and cancer: how intimate is this relationship
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- (2009) F. Colland et al. MOLECULAR CANCER THERAPEUTICS
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- (2009) Jing Shan et al. MOLECULAR CELL
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- (2009) Hiroaki Nagai et al. MOLECULAR CELL
- Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance
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- (2009) Sohrab P. Shah et al. NATURE
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- (2009) N Kon et al. ONCOGENE
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- (2009) Han Liu et al. PLoS One
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- (2008) Abdallah K. Al-Hakim et al. BIOCHEMICAL JOURNAL
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- (2008) Karen H. Ventii et al. BIOCHEMICAL JOURNAL
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- (2008) Lianyun Li et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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- (2008) A. S. Adler et al. CANCER RESEARCH
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- (2008) Fumiyo Ikeda et al. EMBO REPORTS
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- (2008) H. Tran et al. GENES & DEVELOPMENT
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