SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction

(2015) Zhiwei Wang et al.   Oncotarget

Histone H4 Lys 20 methyltransferase SET8 promotes androgen receptor-mediated transcription activation in prostate cancer

(2014) Lushuai Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence

(2014) Mehtap Kilic Eren et al.   PLoS One

Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence

(2014) Yingxi Xu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

microRNA-7 Suppresses the Invasive Potential of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Histone Methyltransferase SET8

(2013) Na Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity

(2013) S. Jorgensen et al.   NUCLEIC ACIDS RESEARCH

Acetylation-Dependent Regulation of Skp2 Function

(2012) Hiroyuki Inuzuka et al.   CELL

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

(2012) Liren Liu et al.   CELL RESEARCH

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

(2012) D. B. Beck et al.   GENES & DEVELOPMENT

SCFβ-TRCPsuppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2

(2012) Shavali Shaik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer

(2012) Cuiju Wang et al.   Cancer Genetics

SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail

(2011) Yinliang Yin et al.   CELL CYCLE

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

(2011) Fen Yang et al.   EMBO JOURNAL

A polymorphism at the miR-502 binding site in the 3′-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome

(2011) Zhanjun Guo et al.   INTERNATIONAL JOURNAL OF CANCER

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

(2011) Stine Jørgensen et al.   JOURNAL OF CELL BIOLOGY

Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4Cdt2 Ubiquitin Ligase Complex

(2011) E. Shibata et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

(2010) Hiroyuki Inuzuka et al.   CANCER CELL

Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression

(2010) S. Wu et al.   GENES & DEVELOPMENT

SETting the Clock for Histone H4 Monomethylation

(2010) Jennifer Lee et al.   MOLECULAR CELL

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

(2010) Richard C. Centore et al.   MOLECULAR CELL

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

(2010) Mathieu Tardat et al.   NATURE CELL BIOLOGY

The Peroxisome Proliferator-Activated Receptor  /Retinoid X Receptor   Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

(2009) K.-i. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2F1 Pathways

(2009) Daming Gao et al.   MOLECULAR BIOLOGY OF THE CELL

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis

(2009) Liren Liu et al.   MOLECULAR CELL

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

(2008) C. Nardella et al.   GENES & DEVELOPMENT

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

(2008) G. Schotta et al.   GENES & DEVELOPMENT

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

Direct Interaction between SET8 and Proliferating Cell Nuclear Antigen Couples H4-K20 Methylation with DNA Replication

(2008) Michael S. Y. Huen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

(2008) Arthur P. Young et al.   NATURE CELL BIOLOGY