Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation

(2017) Ádám I. Csincsi et al.   JOURNAL OF IMMUNOLOGY

Eculizumab-C5 complexes express a C5a neoepitope in vivo : Consequences for interpretation of patient complement analyses

(2017) Per H. Nilsson et al.   MOLECULAR IMMUNOLOGY

Ionic tethering contributes to the conformational stability and function of complement C3b

(2017) Andrés López-Perrote et al.   MOLECULAR IMMUNOLOGY

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

(2017) Xiaoguang Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

(2017) Xiaoguang Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Factor H Family Proteins in Complement Evasion of Microorganisms

(2017) Mihály Józsi   Frontiers in Immunology

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

(2016) Federico Forneris et al.   EMBO JOURNAL

Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway

(2016) Janus Asbjørn Schatz-Jakobsen et al.   JOURNAL OF IMMUNOLOGY

Structural basis for therapeutic inhibition of complement C5

(2016) Matthijs M Jore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for therapeutic inhibition of complement C5

(2016) Matthijs M Jore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

(2015) Evelien T. M. Berends et al.   BMC BIOLOGY

Complement activation, regulation, and molecular basis for complement-related diseases

(2015) G. Bajic et al.   EMBO JOURNAL

Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity

(2015) Georgia Sfyroera et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

(2015) Sofia Mortensen et al.   JOURNAL OF IMMUNOLOGY

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation

(2015) Markus J. Harder et al.   JOURNAL OF IMMUNOLOGY

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

A Revised Mechanism for the Activation of Complement C3 to C3b

(2014) Elizabeth Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

(2014) Michael L. van de Weijer et al.   Nature Communications

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

(2013) M. Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

Functional Analyses of Complement Convertases Using C3 and C5-Depleted Sera

(2012) Marcin Okroj et al.   PLoS One

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional basis for complement evasion by staphylococcal superantigen-like 7

(2010) Jovanka Bestebroer et al.   CELLULAR MICROBIOLOGY

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

(2010) Brandon L. Garcia et al.   JOURNAL OF MOLECULAR BIOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

(2010) Hui Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

(2010) Nick S. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

(2009) Kenneth J. Katschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)

(2009) Nenoo Rawal et al.   MOLECULAR IMMUNOLOGY

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

(2009) Suzan H M Rooijakkers et al.   NATURE IMMUNOLOGY

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5

(2008) Folmer Fredslund et al.   NATURE IMMUNOLOGY