Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b

(2017) Malvina Papanastasiou et al.   JOURNAL OF IMMUNOLOGY

Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity

(2016) Steven P. Broadley et al.   Cell Host & Microbe

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

(2016) Federico Forneris et al.   EMBO JOURNAL

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Online ion-exchange chromatography for small-angle X-ray scattering

(2016) Stephanie Hutin et al.   Acta Crystallographica Section D-Structural Biology

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

(2015) Z. Lin et al.   BLOOD

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

(2015) Sofia Mortensen et al.   JOURNAL OF IMMUNOLOGY

Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins

(2015) Avneesh Kumar Gautam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DATASW, a tool for HPLC–SAXS data analysis

(2015) Alexander V. Shkumatov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3

(2014) Elizabeth Rodriguez et al.   BIOSCIENCE REPORTS

ThePDB_REDOserver for macromolecular structure model optimization

(2014) Robbie P. Joosten et al.   IUCrJ

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Xmipp 3.0: An improved software suite for image processing in electron microscopy

(2013) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Atypical Hemolytic Uremic Syndrome

(2013) David Kavanagh et al.   SEMINARS IN NEPHROLOGY

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

A Novel C3 Mutation Causing Increased Formation of the C3 Convertase in Familial Atypical Hemolytic Uremic Syndrome

(2012) L. Sartz et al.   JOURNAL OF IMMUNOLOGY

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells

(2011) Yu-Hoi Kang et al.   IMMUNOBIOLOGY

Disease-associated N-terminal Complement Factor H Mutations Perturb Cofactor and Decay-accelerating Activities

(2011) Isabell C. Pechtl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3

(2011) Admar Verschoor et al.   NATURE IMMUNOLOGY

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

(2011) Martin Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

(2011) P. Roversi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Analysis of Binding Sites on Complement Factor I That Are Required for Its Activity

(2010) Sara C. Nilsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Swapping Reveals Complement Control Protein Modules Critical for Imparting Cofactor and Decay-Accelerating Activities in Vaccinia Virus Complement Control Protein

(2010) M. Ahmad et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

(2010) B. C. Lechtenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

(2009) I. Moore et al.   BLOOD

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

(2009) Bert J C Janssen et al.   EMBO JOURNAL

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations

(2008) Henry G. Hocking et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Hot Spots in the Variola Virus Complement Inhibitor (SPICE) for Human Complement Regulation

(2008) V. N. Yadav et al.   JOURNAL OF VIROLOGY

Image processing for electron microscopy single-particle analysis using XMIPP

(2008) Sjors H W Scheres et al.   Nature Protocols