Mechanisms of Base Substitution Mutagenesis in Cancer Genomes

Mutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism

(2013) Alan R. Rendina et al.   BIOCHEMISTRY

Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress

(2013) Veslemøy Rolseth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma

(2013) B. Leonard et al.   CANCER RESEARCH

Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes

(2013) Lixing Yang et al.   CELL

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes

(2013) Tae-Min Kim et al.   CELL

Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming

(2013) Chun-Xiao Song et al.   CELL

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

(2013) Silje Z. Krokeide et al.   DNA REPAIR

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported

(2013) Anastasia Galashevskaya et al.   DNA REPAIR

Human Pol ɛ-dependent replication errors and the influence of mismatch repair on their correction

(2013) Anderson Ayuk Agbor et al.   DNA REPAIR

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway

(2013) Peter HL Krijger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Location, location, location: it's all in the timing for replication origins

(2013) O. M. Aparicio   GENES & DEVELOPMENT

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

(2013) Hans F A Vasen et al.   GUT

Error-promoting DNA synthesis in ovarian cancer cells

(2013) Heqiao Dai et al.   GYNECOLOGIC ONCOLOGY

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

A Biochemical Analysis Linking APOBEC3A to Disparate HIV-1 Restriction and Skin Cancer

(2013) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

(2013) Juan Sandoval et al.   JOURNAL OF CLINICAL ONCOLOGY

Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers

(2013) Sarah Briggs et al.   JOURNAL OF PATHOLOGY

Repair of Hydantoin Lesions and Their Amine Adducts in DNA by Base and Nucleotide Excision Repair

(2013) Paige L. McKibbin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deamination, Oxidation, and C–C Bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxycytosine

(2013) Stefan Schiesser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterizing the Protonation State of Cytosine in Transient G·C Hoogsteen Base Pairs in Duplex DNA

(2013) Evgenia N. Nikolova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Whole-Genome Sequencing Analysis Identifies a Distinctive Mutational Spectrum in an Arsenic-Related Lung Tumor

(2013) Victor D. Martinez et al.   Journal of Thoracic Oncology

Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance

(2013) Maria D. Aamann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Repair of oxidatively generated DNA damage in Cockayne syndrome

(2013) Andriy Khobta et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of CSA and CSB protein in the oxidative stress response

(2013) Mariarosaria D’Errico et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Epigenetic profiles as defined signatures of xenobiotic exposure

(2013) John P. Thomson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

(2013) Bryony A Thompson et al.   NATURE GENETICS

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Emerging landscape of oncogenic signatures across human cancers

(2013) Giovanni Ciriello et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Active DNA demethylation in post-mitotic neurons: A reason for optimism

(2013) David P. Gavin et al.   NEUROPHARMACOLOGY

Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma

(2013) Ken Dutton-Regester et al.   Pigment Cell & Melanoma Research

Metabolomic Profiling Unravels DNA Adducts in Human Breast That Are Formed from Peroxidase Mediated Activation of Estrogens to Quinone Methides

(2013) Nilesh W. Gaikwad   PLoS One

DNA polymerase  -interacting protein 2 is a processivity factor for DNA polymerase   during 8-oxo-7,8-dihydroguanine bypass

(2013) G. Maga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

(2013) M. L. Hegde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

(2013) S. L. Poon et al.   Science Translational Medicine

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

(2013) M. L. Hoang et al.   Science Translational Medicine

Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain

(2013) Markus-Frederik Bohn et al.   STRUCTURE

Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing

(2013) Satoshi Yamazaki et al.   TRENDS IN GENETICS

Postreplicative Mismatch Repair

(2013) J. Jiricny   Cold Spring Harbor Perspectives in Biology

Mammalian Transcription-Coupled Excision Repair

(2013) W. Vermeulen et al.   Cold Spring Harbor Perspectives in Biology

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes

(2013) Lin Liu et al.   Nature Communications

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

(2013) Paul Guilhamon et al.   Nature Communications

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

(2013) Lyudmila Y. Kadyrova et al.   PLoS Genetics

Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease

(2013) Albino Bacolla et al.   PLoS Genetics

The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections

(2013) Valdimara C. Vieira et al.   Biomed Research International

Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases

(2013) Atsushi Koito et al.   Frontiers in Microbiology

EMu: probabilistic inference of mutational processes and their localization in the cancer genome

(2013) Andrej Fischer et al.   GENOME BIOLOGY

Classification of H2O2 as a Neuromodulator that Regulates Striatal Dopamine Release on a Subsecond Time Scale

(2012) Jyoti C. Patel et al.   ACS Chemical Neuroscience

Differential Relationship of DNA Replication Timing to Different Forms of Human Mutation and Variation

(2012) Amnon Koren et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Probing the Effects of DNA–Protein Interactions on DNA Hole Transport: The N-Terminal Histone Tails Modulate the Distribution of Oxidative Damage and Chemical Lesions in the Nucleosome Core Particle

(2012) William B. Davis et al.   BIOCHEMISTRY

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non–small cell lung carcinoma from Chinese patients

(2012) Donghai Xiong et al.   CARCINOGENESIS

Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing

(2012) Pengyuan Liu et al.   CARCINOGENESIS

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Regulation of oxidative DNA damage repair: The adenine:8-oxo-guanine problem

(2012) Enni Markkanen et al.   CELL CYCLE

Quantitation of DNA Adducts by Stable Isotope Dilution Mass Spectrometry

(2012) Natalia Tretyakova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation

(2012) Liang Cui et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency

(2012) P. Vasovcak et al.   DNA REPAIR

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

(2012) Berit Doseth et al.   DNA REPAIR

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

(2012) Y. Drier et al.   GENOME RESEARCH

The transcriptional landscape and mutational profile of lung adenocarcinoma

(2012) J.-S. Seo et al.   GENOME RESEARCH

In Situ Analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra

(2012) Kok Seong Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway

(2012) Dimitrios Stathis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability

(2012) A Slupianek et al.   LEUKEMIA

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine

(2012) Masayo Suzuki et al.   MOLECULES

A DNA oligomer containing 2,2,4-triamino-5(2H)-oxazolone is incised by human NEIL1 and NTH1

(2012) Katsuhito Kino et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage

(2012) Minmin Liu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

MBD4 and TDG: Multifaceted DNA glycosylases with ever expanding biological roles

(2012) Ashley B. Sjolund et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chromatin organization is a major influence on regional mutation rates in human cancer cells

(2012) Benjamin Schuster-Böckler et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation

(2012) Christopher S Nabel et al.   Nature Chemical Biology

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Transcription as a source of genome instability

(2012) Nayun Kim et al.   NATURE REVIEWS GENETICS

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

(2012) Hideharu Hashimoto et al.   NUCLEIC ACIDS RESEARCH

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G

(2012) Priyanga Wijesinghe et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

(2012) Bret D. Freudenthal et al.   NUCLEIC ACIDS RESEARCH

Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma

(2012) J Chaisaingmongkol et al.   ONCOGENE

Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability

(2012) V Ruggieri et al.   ONCOGENE

A switch between DNA polymerases   and   promotes error-free bypass of 8-oxo-G lesions

(2012) E. Markkanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer

(2012) A. Mangerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes

(2012) Xiaoshu Chen et al.   SCIENCE

The biochemistry of activation-induced deaminase and its physiological functions

(2012) Mani Larijani et al.   SEMINARS IN IMMUNOLOGY

Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells

(2012) Christine Elisabeth Regnell et al.   Cell Reports

Whole-genome reconstruction and mutational signatures in gastric cancer

(2012) Niranjan Nagarajan et al.   GENOME BIOLOGY

Sequence-Dependent Variation in the Reactivity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine toward Oxidation

(2011) Kok Seong Lim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative analysis of germline and somatic microlesion mutational spectra in 17 human tumor suppressor genes

(2011) Dobril Ivanov et al.   HUMAN MUTATION

Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells

(2011) Albino Bacolla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Crystallographic Study of the Role of Sequence Context in Thymine Glycol Bypass by a Replicative DNA Polymerase Serendipitously Sheds Light on the Exonuclease Complex

(2011) Pierre Aller et al.   JOURNAL OF MOLECULAR BIOLOGY

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts

(2011) Victoria S. Sidorenko et al.   NUCLEIC ACIDS RESEARCH

Base excision repair of 8-oxoG in dinucleosomes

(2011) Hervé Menoni et al.   NUCLEIC ACIDS RESEARCH

Xeroderma pigmentosum

(2011) Alan R Lehmann et al.   Orphanet Journal of Rare Diseases

Functions and regulation of the APOBEC family of proteins

(2011) Harold C. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxidation Reactions of Cytosine DNA Components by Hydroxyl Radical and One-Electron Oxidants in Aerated Aqueous Solutions

(2010) J. Richard Wagner et al.   ACCOUNTS OF CHEMICAL RESEARCH

Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin,

(2010) Jeff Beckman et al.   BIOCHEMISTRY

Crystal Structure of a Replicative DNA Polymerase Bound to the Oxidized Guanine Lesion Guanidinohydantoin ,

(2010) Pierre Aller et al.   BIOCHEMISTRY

Nucleosome structural studies

(2010) Song Tan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer

(2010) Rintaro Yoshida et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The mutational spectrum of non-CpG DNA varies with CpG content

(2010) J.-C. Walser et al.   GENOME RESEARCH

Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells

(2010) Dibyendu Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

(2010) Rahul M. Kohli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper effective binding with 32–62 and 94–125 peptide fragments of histone H2B

(2010) Kimon Zavitsanos et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9–Rad1–Hus1 Checkpoint Complex Interactions

(2010) Paz J. Luncsford et al.   JOURNAL OF MOLECULAR BIOLOGY

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

(2010) William Lee et al.   NATURE

Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity

(2010) Kei-ichi Takata et al.   NUCLEIC ACIDS RESEARCH

The high fidelity and unique error signature of human DNA polymerase  

(2010) D. A. Korona et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions

(2010) Rachel Amouroux et al.   NUCLEIC ACIDS RESEARCH

Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases   and   in human cells

(2010) J.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PCNA function in the activation and strand direction of MutL  endonuclease in mismatch repair

(2010) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA replication fidelity and cancer

(2010) Bradley D. Preston et al.   SEMINARS IN CANCER BIOLOGY

Mutator phenotypes due to DNA replication infidelity

(2010) Mercedes E. Arana et al.   SEMINARS IN CANCER BIOLOGY

The current structural and functional understanding of APOBEC deaminases

(2009) Ronda Bransteitter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

(2009) Michael K. Chan et al.   DNA REPAIR

Mutational spectra of human cancer

(2009) Gerd P. Pfeifer et al.   HUMAN GENETICS

Hydrolytic Deamination of 5-Methylcytosine in Protic MediumA Theoretical Study

(2009) Vanessa Labet et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Relationship between TP53 tumour suppressor gene mutations and smoking-related bulky DNA adducts in a lung cancer study population from Hungary

(2009) Lívia Anna et al.   MUTAGENESIS

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Human mutation rate associated with DNA replication timing

(2009) John A Stamatoyannopoulos et al.   NATURE GENETICS

Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis

(2009) Ruzaliya Fazlieva et al.   NUCLEIC ACIDS RESEARCH

Kinetics of deamination and Cu(II)/H 2 O 2 /Ascorbate-induced formation of 5-methylcytosine glycol at CpG sites in duplex DNA

(2009) Huachuan Cao et al.   NUCLEIC ACIDS RESEARCH

Superior Removal of Hydantoin Lesions Relative to Other Oxidized Bases by the Human DNA Glycosylase hNEIL1†

(2008) Nirmala Krishnamurthy et al.   BIOCHEMISTRY

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

MBD4-Mediated Glycosylase Activity on a Chromatin Template Is Enhanced by Acetylation

(2008) T. Ishibashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE