Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

(2011) L. Zhang et al.   GENES & DEVELOPMENT

Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

(2011) Vincenzo Sorrentino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

(2011) Eric B. Dammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists

(2011) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

ErbB2 Trafficking and Degradation Associated with K48 and K63 Polyubiquitination

(2010) Corina Marx et al.   CANCER RESEARCH

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

(2009) Yasushi Saeki et al.   EMBO JOURNAL

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

(2009) Elsa Lauwers et al.   JOURNAL OF CELL BIOLOGY

The Structure and Conformation of Lys63-Linked Tetraubiquitin

(2009) Ajit B. Datta et al.   JOURNAL OF MOLECULAR BIOLOGY

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

(2009) Ming Xu et al.   MOLECULAR CELL

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

(2009) Jessica M. Boname et al.   TRAFFIC

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Polyubiquitination of Prolactin Receptor Stimulates Its Internalization, Postinternalization Sorting, and Degradation via the Lysosomal Pathway

(2008) B. Varghese et al.   MOLECULAR AND CELLULAR BIOLOGY