Parkin overexpression ameliorates hippocampal long-term potentiation and  -amyloid load in an Alzheimer's disease mouse model

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Parkin in the regulation of fat uptake and mitochondrial biology

(2012) Kye-Young Kim et al.   CURRENT OPINION IN LIPIDOLOGY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

(2012) Minjuan Bian et al.   PLoS One

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

(2011) Nada A. Abumrad et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear Translocation of Jacob in Hippocampal Neurons after Stimuli Inducing Long-Term Potentiation but Not Long-Term Depression

(2011) Thomas Behnisch et al.   PLoS One

Schema-Dependent Gene Activation and Memory Encoding in Neocortex

(2011) D. Tse et al.   SCIENCE

Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons

(2011) Ying Chen et al.   SYNAPSE

MPTP-meditated hippocampal dopamine deprivation modulates synaptic transmission and activity-dependent synaptic plasticity

(2011) GuoQi Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation

(2010) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

β-Amyloid1–42Gene Transfer Model Exhibits Intraneuronal Amyloid, Gliosis, Tau Phosphorylation, and Neuronal Loss

(2010) G. William Rebeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Directly Modulates 26S Proteasome Activity

(2010) J. W. Um et al.   JOURNAL OF NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation

(2010) F. Cai et al.   NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

(2010) Latha Devi et al.   Molecular Brain

Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease

(2009) Lingfei Ruan et al.   Current Alzheimer Research

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant  -Synuclein

(2009) X.-H. Lu et al.   JOURNAL OF NEUROSCIENCE

Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice

(2009) Randy L. Hunter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells

(2008) Minjuan Bian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene

(2008) Rosa Guerrero et al.   ACTA NEUROPATHOLOGICA

Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks

(2008) F.E. Harrison et al.   BEHAVIOURAL BRAIN RESEARCH

Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease

(2008) M. Filali et al.   GENES BRAIN AND BEHAVIOR

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

(2008) Jose A. Rodríguez-Navarro et al.   HUMAN MOLECULAR GENETICS

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Parkin Attenuates Wild-Type τ Modification in the Presence of β-Amyloid and α-Synuclein

(2008) Charbel E.-H. Moussa   JOURNAL OF MOLECULAR NEUROSCIENCE