NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

(2010) Andrea C Eitelhuber et al.   EMBO JOURNAL

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

(2010) B. Kloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

NEMO oligomerization and its ubiquitin-binding properties

(2009) Frank J. Ivins et al.   BIOCHEMICAL JOURNAL

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

(2009) E Laplantine et al.   EMBO JOURNAL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

(2009) Azusa Yoshikawa et al.   FEBS LETTERS

DARPin-Assisted Crystallography of the CC2-LZ Domain of NEMO Reveals a Coupling between Dimerization and Ubiquitin Binding

(2009) Olivera Grubisha et al.   JOURNAL OF MOLECULAR BIOLOGY

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

(2009) Ming Xu et al.   MOLECULAR CELL

Structural Basis for Recognition of Diubiquitins by NEMO

(2009) Yu-Chih Lo et al.   MOLECULAR CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

(2009) Yogesh Kulathu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Alterations of the IKBKG locus and diseases: an update and a report of 13 novel mutations

(2008) Francesca Fusco et al.   HUMAN MUTATION

Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity

(2008) Eric P. Hanson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain

(2008) Florence Cordier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY