Glucocerebrosidase 1 deficientDanio reriomirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies

(2016) Robert N. Wilkinson et al.   BIOTECHNIQUES

Methods for studying the zebrafish brain: past, present and future

(2015) Cameron Wyatt et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocerebrosidase and Parkinson disease: Recent advances

(2015) Anthony H.V. Schapira   MOLECULAR AND CELLULAR NEUROSCIENCE

Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

(2015) Norihito Uemura et al.   PLoS Genetics

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Glucocerebrosidase deficits in sporadic Parkinson disease

(2014) Karen E Murphy et al.   Autophagy

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

Glucocerebrosidase is shaking up the synucleinopathies

(2014) Marina Siebert et al.   BRAIN

Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling

(2014) Ilaria Zancan et al.   HUMAN MOLECULAR GENETICS

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

(2014) Joana R. Guedes et al.   HUMAN MOLECULAR GENETICS

Different Mechanisms Regulate Expression of Zebrafish Myelin Protein Zero (P0) in Myelinating Oligodendrocytes and Its Induction following Axonal Injury

(2014) Qing Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR/Cas9 and TALEN-mediated knock-in approaches in zebrafish

(2014) Thomas O. Auer et al.   METHODS

Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease

(2014) Lucilla Parnetti et al.   MOVEMENT DISORDERS

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

TigarBcauses mitochondrial dysfunction and neuronal loss in PINK1 deficiency

(2013) Laura J. Flinn et al.   ANNALS OF NEUROLOGY

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration

(2013) T. Farfel-Becker et al.   HUMAN MOLECULAR GENETICS

miR-155: an ancient regulator of the immune system

(2013) Elena Vigorito et al.   IMMUNOLOGICAL REVIEWS

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies

(2013) S. Pablo Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Of fish and men: using zebrafish to fight human diseases

(2013) Julien Ablain et al.   TRENDS IN CELL BIOLOGY

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs WithoutGBAMutations

(2013) Lama M. Chahine et al.   JAMA Neurology

Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry

(2012) Hai H. Bui et al.   ANALYTICAL BIOCHEMISTRY

Early interneuron dysfunction in ALS: Insights from a mutantsod1zebrafish model

(2012) Alexander McGown et al.   ANNALS OF NEUROLOGY

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease

(2012) Einat B. Vitner et al.   BRAIN

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

(2012) Peter Holmans et al.   HUMAN MOLECULAR GENETICS

GBA-associated PD: Neurodegeneration, altered membrane metabolism, and lack of energy failure

(2012) K. Brockmann et al.   NEUROLOGY

Cognitive performance of GBA mutation carriers with early-onset PD: The CORE-PD study

(2012) R. N. Alcalay et al.   NEUROLOGY

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Animal models for Gaucher disease research

(2011) T. Farfel-Becker et al.   Disease Models & Mechanisms

Hypokinesia and Reduced Dopamine Levels in Zebrafish Lacking β- and γ1-Synucleins

(2011) Chiara Milanese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

Major isoform of zebrafish P0 is a 23.5 kDa myelin glycoprotein expressed in selected white matter tracts of the central nervous system

(2010) Qing Bai et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Genetic zebrafish models of neurodegenerative diseases

(2010) Oliver Bandmann et al.   NEUROBIOLOGY OF DISEASE

Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage

(2010) P. K. Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)

(2009) L. Flinn et al.   BRAIN

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MPTP and MPP+ target specific aminergic cell populations in larval zebrafish

(2008) V Sallinen et al.   JOURNAL OF NEUROCHEMISTRY