Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

(2017) Ayelén Bulloj et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos

(2011) Ann M. Wehman et al.   CURRENT BIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

(2011) Frederik J Verweij et al.   EMBO JOURNAL

Can α-synuclein be targeted in novel therapies for Parkinson’s disease?

(2011) Patrik Brundin et al.   Expert Review of Neurotherapeutics

Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of the Posterior Pole Is Mediated by the Exosome/Microvesicle Protein-sorting Pathway

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

(2011) Allal Boutajangout et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

(2011) T. LHERMUSIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Amyloid by default

(2011) Lary C Walker et al.   NATURE NEUROSCIENCE

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Transmission of prions within the gut and towards the central nervous system

(2011) Gianfranco Natale et al.   Prion

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

(2011) L. I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism

(2010) Masayoshi Tasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies

(2010) R Núñez et al.   CELL DEATH AND DIFFERENTIATION

A New Hypothesis of Pathogenesis Based on the Divorce between Mitochondria and their Host Cells: Possible Relevance for Alzheimers Disease

(2010) L.F. Agnati et al.   Current Alzheimer Research

Macromolecular crowding converts the human recombinant PrPC to the soluble neurotoxic β-oligomers

(2010) Liqin Huang et al.   FASEB JOURNAL

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

(2010) Katrin Strauss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Biomarkers in translational research of Alzheimer’s Disease

(2010) Rawan Tarawneh et al.   NEUROPHARMACOLOGY

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples

(2010) Javier Conde-Vancells et al.   Proteomics Clinical Applications

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Rethinking ALS: The FUS about TDP-43

(2009) Clotilde Lagier-Tourenne et al.   CELL

Tau-Focused Immunotherapy for Alzheimers Disease and Related Tauopathies

(2009) Einar Sigurdsson   Current Alzheimer Research

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Serum amyloid A and protein AA: Molecular mechanisms of a transmissible amyloidosis

(2009) Gunilla T. Westermark et al.   FEBS LETTERS

Transbilayer (flip-flop ) lipid motion and lipid scrambling in membranes

(2009) F.-Xabier Contreras et al.   FEBS LETTERS

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

(2009) Suresh Mathivanan et al.   MOLECULAR & CELLULAR PROTEOMICS

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ALS motor phenotype heterogeneity, focality, and spread: Deconstructing motor neuron degeneration

(2009) J. M. Ravits et al.   NEUROLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats

(2009) I.V. Kraev et al.   NEUROSCIENCE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

(2009) Yan Qu et al.   Purinergic Signalling

Identification of an Intracellular Site of Prion Conversion

(2009) Zrinka Marijanovic et al.   PLoS Pathogens

Diffusible amyloid oligomers trigger systemic amyloidosis in mice

(2008) Sivanesan Senthilkumar et al.   BIOCHEMICAL JOURNAL

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

(2008) A Lespagnol et al.   CELL DEATH AND DIFFERENTIATION

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY

Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy

(2008) Nathalie M. Veith et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS

(2008) Makoto Urushitani et al.   FASEB JOURNAL

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

The art of cellular communication: tunneling nanotubes bridge the divide

(2008) Steffen Gurke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Formation of Pmel17 Amyloid Is Regulated by Juxtamembrane Metalloproteinase Cleavage, and the Resulting C-terminal Fragment Is a Substrate for γ-Secretase

(2008) Markus P. Kummer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site

(2008) S. F. Godsave et al.   JOURNAL OF NEUROSCIENCE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Abnormal prion protein is associated with changes of plasma membranes and endocytosis in bovine spongiform encephalopathy (BSE)-affected cattle brains

(2008) C. Ersdal et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

AA-Amyloidosis Can Be Transferred by Peripheral Blood Monocytes

(2008) Jana Sponarova et al.   PLoS One

Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease

(2008) B. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Itinerant exosomes: emerging roles in cell and tissue polarity

(2008) Aparna Lakkaraju et al.   TRENDS IN CELL BIOLOGY

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

(2008) Laura J. Vella et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY