Innovative Biomarkers for Alzheimer’s Disease: Focus on the Hidden Disease Biomarkers

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Free copper in serum: An analytical challenge and its possible applications

(2018) Simona Catalani et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

(2017) Harutsugu Tatebe et al.   Molecular Neurodegeneration

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load

(2017) K Goozee et al.   MOLECULAR PSYCHIATRY

Association of Serum Manganese Levels with  Alzheimer’s Disease and Mild Cognitive Impairment:  A Systematic Review and Meta‐Analysis

(2017) Ke Du et al.   Nutrients

Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies

(2017) Dan-Dan Li et al.   Frontiers in Aging Neuroscience

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers

(2017) Scott Ayton et al.   JAMA Neurology

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

(2017) Niklas Mattsson et al.   JAMA Neurology

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

(2017) Maja Mustapic et al.   Frontiers in Neuroscience

Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort

(2016) Jeffrey L. Dage et al.   Alzheimers & Dementia

Combined mass quantitation and phenotyping of intact extracellular vesicles by a microarray platform

(2016) Paola Gagni et al.   ANALYTICA CHIMICA ACTA

Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease

(2016) Andreas Nabers et al.   ANALYTICAL CHEMISTRY

Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa

(2016) Jens Kuhle et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity

(2016) Franca Tecchio et al.   Current Alzheimer Research

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Small Molecule Copper and Its Relative Metabolites in Serum of Cerebral Ischemic Stroke Patients

(2016) Minchao Lai et al.   Journal of Stroke & Cerebrovascular Diseases

Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease

(2016) Vo Van Giau et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

(2016) M. C. Linder   Metallomics

Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer’s Disease: a Genetic Study of ATP7B Frequency

(2016) Rosanna Squitti et al.   MOLECULAR NEUROBIOLOGY

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

Alzheimer’s disease due to loss of function: A new synthesis of the available data

(2016) Kasper P. Kepp   PROGRESS IN NEUROBIOLOGY

A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics

(2016) Linan Song et al.   Alzheimers Research & Therapy

Small Molecule Copper and Its Relative Metabolites in Serum of Cerebral Ischemic Stroke Patients

(2016) Minchao Lai et al.   Journal of Stroke & Cerebrovascular Diseases

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

(2016) Rawan Tarawneh et al.   JAMA Neurology

Plasma neurofilament light chain predicts progression in progressive supranuclear palsy

(2016) Julio C. Rojas et al.   Annals of Clinical and Translational Neurology

Neurofilament light chain: a biomarker for genetic frontotemporal dementia

(2016) Lieke H. Meeter et al.   Annals of Clinical and Translational Neurology

Plasma β-amyloid in Alzheimer’s disease and vascular disease

(2016) Shorena Janelidze et al.   Scientific Reports

Digital Detection of Exosomes by Interferometric Imaging

(2016) George G. Daaboul et al.   Scientific Reports

The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey

(2015) Martina Bocchetta et al.   Alzheimers & Dementia

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage

(2015) Stephanie J. B. Vos et al.   BRAIN

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

(2015) Pooja Joshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids

(2015) Andreas Nabers et al.   Journal of Biophotonics

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

(2015) Ting Yang et al.   Alzheimers Research & Therapy

Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease

(2015) Maartje I. Kester et al.   JAMA Neurology

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

(2015) Giovanni Lugli et al.   PLoS One

Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

(2014) Rosanna Squitti et al.   ANNALS OF NEUROLOGY

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease

(2014) Federica Agosta et al.   ANNALS OF NEUROLOGY

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Roles of Extracellular Vesicles in the Nervous System

(2014) L. Rajendran et al.   JOURNAL OF NEUROSCIENCE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Familial Alzheimer's disease sustained by presenilin 2 mutations: Systematic review of literature and genotype–phenotype correlation

(2014) Marco Canevelli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Human Cerebrospinal Fluid Fatty Acid Levels Differ between Supernatant Fluid and Brain-Derived Nanoparticle Fractions, and Are Altered in Alzheimer's Disease

(2014) Alfred N. Fonteh et al.   PLoS One

A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles

(2014) Sylvain Lehmann et al.   Alzheimers Research & Therapy

ATR-FTIR: A “rejuvenated” tool to investigate amyloid proteins

(2013) Rabia Sarroukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Metal-Score as a Potential Non-Invasive Diagnostic Test for Alzheimer’s Disease

(2013) Rosanna Squitti et al.   Current Alzheimer Research

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

(2013) M. Schrag et al.   NEUROBIOLOGY OF DISEASE

CSF biomarkers of Alzheimer disease: "Noncognitive" outcomes

(2013) C. M. Roe et al.   NEUROLOGY

Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI

(2013) S. J. B. Vos et al.   NEUROLOGY

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

(2013) Kyongman An et al.   Molecular Brain

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

(2012) I. A. van Rossum et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Good gene, bad gene: New APP variant may be both

(2012) Giuseppe Di Fede et al.   PROGRESS IN NEUROBIOLOGY

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Relative exchangeable copper: A new highly sensitive and highly specific biomarker for Wilson's disease diagnosis

(2011) Souleiman El Balkhi et al.   CLINICA CHIMICA ACTA

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different CSF β-amyloid processing in Alzheimer’s and Creutzfeldt–Jakob disease

(2011) Brit Mollenhauer et al.   JOURNAL OF NEURAL TRANSMISSION

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Cumulative Lead Dose and Cognitive Function in Older Adults

(2010) Karen Bandeen-Roche et al.   EPIDEMIOLOGY

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

CSF biomarkers predict a more malignant outcome in Alzheimer disease

(2010) A. K. Wallin et al.   NEUROLOGY

Direct Measurement of Free Copper in Serum or Plasma Ultrafiltrate

(2009) Gwendolyn A. McMillin et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Determination of ultrafiltrable and exchangeable copper in plasma: stability and reference values in healthy subjects

(2009) Souleiman El Balkhi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives

(2009) Nathalie Arnal et al.   BRAIN RESEARCH

Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity

(2009) Kajsa Sämgård et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

CSF phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and Alzheimer's disease: a meta-analysis of 51 studies

(2009) A J Mitchell   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease

(2009) Roberta Ghidoni et al.   NEUROBIOLOGY OF AGING

Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease

(2009) R. Squitti et al.   NEUROLOGY

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Molecular polymorphism of Aβ in Alzheimer's disease

(2008) Harry LeVine et al.   NEUROBIOLOGY OF AGING

Free Copper, Ferroxidase and SOD1 Activities, Lipid Peroxidation and NO x Content in the CSF. A Different Marker Profile in Four Neurodegenerative Diseases

(2008) Marie-Catherine Boll et al.   NEUROCHEMICAL RESEARCH