Amyloid formation: functional friend or fearful foe?

AA Amyloidosis: Pathogenesis and Targeted Therapy

(2015) Gunilla T. Westermark et al.   Annual Review of Pathology-Mechanisms of Disease

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

ATG16L1: A multifunctional susceptibility factor in Crohn disease

(2015) Mohammad Salem et al.   Autophagy

Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity

(2015) Paul M. Gallo et al.   IMMUNITY

Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues

(2015) Shannon A. Allen et al.   JOURNAL OF VIROLOGY

The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

(2015) Margery L. Evans et al.   MOLECULAR CELL

Improving preclinical models of HIV microbicide efficacy

(2015) Nadia R. Roan et al.   TRENDS IN MICROBIOLOGY

Enhancement of Herpes Simplex Virus (HSV) Infection by Seminal Plasma and Semen Amyloids Implicates a New Target for the Prevention of HSV Infection

(2015) Lilith Torres et al.   Viruses-Basel

Microbial-generated amyloids and Alzheimer's disease (AD)

(2015) James M. Hill et al.   Frontiers in Aging Neuroscience

A molecular tweezer antagonizes seminal amyloids and HIV infection

(2015) Edina Lump et al.   eLife

New insight into the molecular control of bacterial functional amyloids

(2015) Jonathan D. Taylor et al.   Frontiers in Cellular and Infection Microbiology

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

(2015) Erik Chorell et al.   PLoS One

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Structural Characterization of Semen Coagulum-Derived SEM1(86–107) Amyloid Fibrils That Enhance HIV-1 Infection

(2014) Kinsley C. French et al.   BIOCHEMISTRY

Selection of Unadapted, Pathogenic SHIVs Encoding Newly Transmitted HIV-1 Envelope Proteins

(2014) Gregory Q. Del Prete et al.   Cell Host & Microbe

Regulation of biofilm formation inSalmonella entericaserovar Typhimurium

(2014) Roger Simm et al.   Future Microbiology

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

(2014) Glenn J. Rapsinski et al.   INFECTION AND IMMUNITY

Interaction of Fibronectin With Semen Amyloids Synergistically Enhances HIV Infection

(2014) Nadia R. Roan et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Basis for Self-Assembly of a Human Host-Defense Peptide That Entraps Bacterial Pathogens

(2014) Phoom Chairatana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection

(2014) N. R. Roan et al.   JOURNAL OF VIROLOGY

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

(2014) B O Schroeder et al.   Mucosal Immunology

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring

(2014) John J. Bromfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides

(2014) O. Zirafi et al.   Science Translational Medicine

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen

(2014) Shariq M. Usmani et al.   Nature Communications

Semen-Derived Enhancer of Viral Infection (SEVI) Binds Bacteria, Enhances Bacterial Phagocytosis by Macrophages, and Can Protect against Vaginal Infection by a Sexually Transmitted Bacterial Pathogen

(2013) David Easterhoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Seminal Plasma and Semen Amyloids Enhance Cytomegalovirus Infection in Cell Culture

(2013) Qiyi Tang et al.   JOURNAL OF VIROLOGY

A unifying theory for the crypt

(2013) Hans Clevers   NATURE

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

(2013) Ashley L Hilchie et al.   Nature Chemical Biology

Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus

(2013) Jan Münch et al.   Retrovirology

Disease to Dirt: The Biology of Microbial Amyloids

(2013) David A. Hufnagel et al.   PLoS Pathogens

Core Sequence of PAPf39 Amyloid Fibrils and Mechanism of pH-Dependent Fibril Formation: The Role of Monomer Conformation

(2012) Kinsley C. French et al.   BIOCHEMISTRY

Curli Functional Amyloid Systems Are Phylogenetically Widespread and Display Large Diversity in Operon and Protein Structure

(2012) Morten S. Dueholm et al.   PLoS One

Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa

(2012) Y. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection

(2011) Nadia R. Roan et al.   Cell Host & Microbe

Tenofovir-based pre-exposure prophylaxis for HIV prevention

(2011) Connie Celum et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Naturally Occurring Fragments from Two Distinct Regions of the Prostatic Acid Phosphatase Form Amyloidogenic Enhancers of HIV Infection

(2011) F. Arnold et al.   JOURNAL OF VIROLOGY

The role of semen in sexual transmission of HIV: beyond a carrier for virus particles

(2011) Juan Sabatté et al.   MICROBES AND INFECTION

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)- and Semen-mediated Enhancement of HIV-1 Infection

(2010) Joanna S. Olsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trp-26 Imparts Functional Versatility to Human α-Defensin HNP1

(2010) Gang Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

(2010) Thibaud Lebouvier et al.   PLoS One

Amyloid fibers provide structural integrity to Bacillus subtilis biofilms

(2010) D. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI

(2010) Kyeong-Ae Kim et al.   Retrovirology

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization

(2010) Jason G. Smith et al.   PLoS Pathogens

Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37

(2010) Ylva Kai-Larsen et al.   PLoS Pathogens

Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies

(2009) Julius Atashili et al.   AIDS

Aminoquinoline Surfen Inhibits the Action of SEVI (Semen-derived Enhancer of Viral Infection)

(2009) Nadia R. Roan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multivalent Binding of Carbohydrates by the Human  -Defensin, HD5

(2009) R. I. Lehrer et al.   JOURNAL OF IMMUNOLOGY

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection

(2009) I. Hauber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection

(2008) N. R. Roan et al.   JOURNAL OF VIROLOGY

Whither or Wither Microbicides?

(2008) R. M. Grant et al.   SCIENCE