Exploring New Biological Functions of Amyloids: Bacteria Cell Agglutination Mediated by Host Protein Aggregation

Antimicrobial Action and Cell Agglutination by the Eosinophil Cationic Protein Are Modulated by the Cell Wall Lipopolysaccharide Structure

(2012) David Pulido et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural determinants of the eosinophil cationic protein antimicrobial activity

(2012) Ester Boix et al.   BIOLOGICAL CHEMISTRY

Discovering New In Silico Tools for Antimicrobial Peptide Prediction

(2012) Marc Torrent et al.   CURRENT DRUG TARGETS

Aberrant action of amyloidogenic host defense peptides: a new paradigm to investigate neurodegenerative disorders?

(2012) Frederick Harris et al.   FASEB JOURNAL

Lipopolysaccharide Neutralization by Antimicrobial Peptides: A Gambit in the Innate Host Defense Strategy

(2012) David Pulido et al.   Journal of Innate Immunity

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Site Specific Interaction of the Polyphenol EGCG with the SEVI Amyloid Precursor Peptide PAP(248–286)

(2012) Nataliya Popovych et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?

(2011) Marc Torrent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AMPA: an automated web server for prediction of protein antimicrobial regions

(2011) Marc Torrent et al.   BIOINFORMATICS

Antimicrobial Protegrin-1 Forms Amyloid-Like Fibrils with Rapid Kinetics Suggesting a Functional Link

(2011) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Refining the Eosinophil Cationic Protein Antibacterial Pharmacophore by Rational Structure Minimization

(2011) Marc Torrent et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Properties of Amyloid Peptides

(2011) Bruce L. Kagan et al.   MOLECULAR PHARMACEUTICS

Connecting Peptide Physicochemical and Antimicrobial Properties by a Rational Prediction Model

(2011) Marc Torrent et al.   PLoS One

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

(2010) William C. Wimley   ACS Chemical Biology

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Limiting an Antimicrobial Peptide to the Lipid−Water Interface Enhances Its Bacterial Membrane Selectivity: A Case Study of MSI-367

(2010) Sathiah Thennarasu et al.   BIOCHEMISTRY

Mapping the eosinophil cationic protein antimicrobial activity by chemical and enzymatic cleavage

(2010) Daniel Sánchez et al.   BIOCHIMIE

Eosinophil Cationic Protein Aggregation: Identification of an N-Terminus Amyloid Prone Region

(2010) Marc Torrent et al.   BIOMACROMOLECULES

Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall

(2010) Marc Torrent et al.   FEBS Journal

Eosinophil cationic protein (ECP) can bind heparin and other glycosaminoglycans through its RNase active site

(2010) Marc Torrent et al.   JOURNAL OF MOLECULAR RECOGNITION

Eosinophil-induced neurotoxicity: The role of eosinophil cationic protein/RNase 3

(2010) Susanna Navarro et al.   JOURNAL OF NEUROIMMUNOLOGY

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment

(2009) Marc Torrent et al.   BIOCHEMICAL JOURNAL

Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7

(2009) Marc Torrent et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Helical Conformation of the SEVI Precursor Peptide PAP248-286, a Dramatic Enhancer of HIV Infectivity, Promotes Lipid Aggregation and Fusion

(2009) Jeffrey R. Brender et al.   BIOPHYSICAL JOURNAL

A theoretical approach to spot active regions in antimicrobial proteins

(2009) Marc Torrent et al.   BMC BIOINFORMATICS

NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248−286

(2009) Ravi P. R. Nanga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

(2009) Ravi Prakash Reddy Nanga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine—a new element in the design of membrane-active peptides

(2009) E. Neil G. Marsh et al.   Molecular BioSystems

Structure and mechanism of β-hairpin antimicrobial peptides in lipid bilayers from solid-state NMR spectroscopy

(2009) Ming Tang et al.   Molecular BioSystems

Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights

(2009) Ayyalusamy Ramamoorthy   SOLID STATE NUCLEAR MAGNETIC RESONANCE

A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†

(2008) Jeffrey R. Brender et al.   BIOCHEMISTRY

Eosinophil Cationic Protein High-Affinity Binding to Bacteria-Wall Lipopolysaccharides and Peptidoglycans†

(2008) Marc Torrent et al.   BIOCHEMISTRY

Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin

(2008) Lindsey M. Gottler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Antipathogen Activities of Eosinophil Cationic Protein

(2008) Ester Boix et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Structural requirements for antimicrobial versus chemoattractant activities for dermaseptin S9

(2008) Constance Auvynet et al.   FEBS Journal

Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide

(2008) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of bacteria-agglutinating peptides derived from parotid secretory protein, a member of the bactericidal/permeability increasing-like protein family

(2008) Sven-Ulrik Gorr et al.   PEPTIDES