Multifaceted half-sandwich arene–ruthenium complexes: interactions with biomolecules, photoactivation, and multinuclearity approach

Biomedical and Biochemical Applications of Self-Assembled Metallacycles and Metallacages

(2013) Timothy R. Cook et al.   ACCOUNTS OF CHEMICAL RESEARCH

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

(2013) Wolfgang Kandioller et al.   CHEMICAL COMMUNICATIONS

Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

(2013) Wei Zheng et al.   CHEMICAL COMMUNICATIONS

Exploration of the medical periodic table: towards new targets

(2013) Nicolas P. E. Barry et al.   CHEMICAL COMMUNICATIONS

The path for metal complexes to a DNA target

(2013) Alexis C. Komor et al.   CHEMICAL COMMUNICATIONS

Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents

(2013) Swagata Banerjee et al.   CHEMICAL SOCIETY REVIEWS

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

(2013) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

A ruthenium(ii) arene complex showing emission enhancement and photocleavage activity towards DNA from singlet and triplet excited states respectively

(2013) Yongjie Chen et al.   DALTON TRANSACTIONS

Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation

(2013) Qiong Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells

(2013) Wei Guo et al.   INORGANIC CHEMISTRY

The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway

(2013) Isolda Romero-Canelón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Growth Inhibitory Activity of a Bis-Benzimidazole-Bridged Arene Ruthenium Metalla-Rectangle and -Prism

(2013) Vaishali Vajpayee et al.   ORGANOMETALLICS

Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation

(2013) Lukas K. Filak et al.   ORGANOMETALLICS

Enzyme inhibition by metal complexes: concepts, strategies and applications

(2013) Kelly J. Kilpin et al.   Chemical Science

Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor

(2012) Soledad Betanzos-Lara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delivery of Floxuridine Derivatives to Cancer Cells by Water-Soluble Organometallic Cages

(2012) Jeong Wu Yi et al.   BIOCONJUGATE CHEMISTRY

Somatostatin Subtype-2 Receptor-Targeted Metal-Based Anticancer Complexes

(2012) Flavia Barragán et al.   BIOCONJUGATE CHEMISTRY

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Designing organometallic compounds for catalysis and therapy

(2012) Anna Louisa Noffke et al.   CHEMICAL COMMUNICATIONS

Metal complex catalysis in living biological systems

(2012) Pijus K. Sasmal et al.   CHEMICAL COMMUNICATIONS

Coordination-driven self-assembly of ruthenium-based molecular-rectangles: Synthesis, characterization, photo-physical and anticancer potency studies

(2012) Vaishali Vajpayee et al.   DALTON TRANSACTIONS

Targeted therapy vs. DNA-adduct formation-guided design: thoughts about the future of metal-based anticancer drugs

(2012) Gianni Sava et al.   DALTON TRANSACTIONS

Cellular delivery of pyrenyl-arene ruthenium complexes by a water-soluble arene ruthenium metalla-cage

(2012) Mona Anca Furrer et al.   DALTON TRANSACTIONS

Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

(2012) Vaishali Vajpayee et al.   DALTON TRANSACTIONS

The influence of RAPTA moieties on the antiproliferative activity of peripheral-functionalised poly(salicylaldiminato) metallodendrimers

(2012) Preshendren Govender et al.   DALTON TRANSACTIONS

Ruthenium(ii) arene PTA (RAPTA) complexes: impact of enantiomerically pure chiral ligands

(2012) Kelly J. Kilpin et al.   DALTON TRANSACTIONS

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure–activity relationships and stability studies on RuII(arene) anticancer complexes with biologically active ligands

(2012) Andrea Kurzwernhart et al.   DALTON TRANSACTIONS

Competition between glutathione and DNA oligonucleotides for ruthenium(ii) arene anticancer complexes

(2012) Fuyi Wang et al.   DALTON TRANSACTIONS

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

(2012) Alexey A. Nazarov et al.   DALTON TRANSACTIONS

Evaluation of arene ruthenium(ii) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

(2012) Luciano Oehninger et al.   DALTON TRANSACTIONS

Bio-Metallodendrimers - Emerging Strategies in Metal-Based Drug Design

(2012) Preshendren Govender et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands

(2012) Andrea Kurzwernhart et al.   JOURNAL OF MEDICINAL CHEMISTRY

A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines

(2012) Werner Ginzinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells

(2012) Alberto Martínez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systems biology approach for in vivo photodynamic therapy optimization of ruthenium-porphyrin compounds

(2012) Marlène Pernot et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes

(2012) Isolda Romero-Canelón et al.   Metallomics

Photoactivatable Organometallic Pyridyl Ruthenium(II) Arene Complexes

(2012) Soledad Betanzos-Lara et al.   ORGANOMETALLICS

Cytotoxicity of Ruthenium–Arene Complexes Containing β-Ketoamine Ligands

(2012) Riccardo Pettinari et al.   ORGANOMETALLICS

Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex

(2012) Rosana Hudej et al.   ORGANOMETALLICS

Anticancer Activity of Self-Assembled Molecular Rectangles via Arene–Ruthenium Acceptors and a New Unsymmetrical Amide Ligand

(2012) Anurag Mishra et al.   ORGANOMETALLICS

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Naphthalimide-Tagged Ruthenium–Arene Anticancer Complexes: Combining Coordination with Intercalation

(2012) Kelly J. Kilpin et al.   ORGANOMETALLICS

Predicting the interactions of organometallic ruthenium ethylenediamine complexes with mononucleotides: insights from density functional theory

(2012) Hanlu Wang et al.   RSC Advances

Metal Complexes as DNA Intercalators

(2011) Hong-Ke Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity

(2011) Eric Meggers   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents

(2011) Vaishali Vajpayee et al.   CHEMICAL COMMUNICATIONS

Anticancer activity of tetracationic arene ruthenium metalla-cycles

(2011) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Metal-based antitumour drugs in the post-genomic era: what comes next?

(2011) Gianni Sava et al.   DALTON TRANSACTIONS

Targeted and multifunctional arene ruthenium chemotherapeutics

(2011) Gregory S. Smith et al.   DALTON TRANSACTIONS

Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex

(2011) Federico Giannini et al.   INORGANIC CHEMISTRY

Picolinate ruthenium(II)–arene complex with in vitro antiproliferative and antimetastatic properties: Comparison to a series of ruthenium(II)–arene complexes with similar structure

(2011) Nevenka Gligorijević et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ruthenium–Arene Complexes of Curcumin: X-Ray and Density Functional Theory Structure, Synthesis, and Spectroscopic Characterization, in Vitro Antitumor Activity, and DNA Docking Studies of (p-Cymene)Ru(curcuminato)chloro

(2011) Francesco Caruso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

(2011) Frédéric Schmitt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex

(2011) Flavia Barragán et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differences in the Cellular Response and Signaling Pathways between Cisplatin and Monodentate Organometallic Ru(II) Antitumor Complexes Containing a Terphenyl Ligand

(2011) Anna Kisova et al.   MOLECULAR PHARMACEUTICS

Physicochemical Studies and Anticancer Potency of Ruthenium η6-p-Cymene Complexes Containing Antibacterial Quinolones

(2011) Jakob Kljun et al.   ORGANOMETALLICS

Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors

(2011) Sebastian Blanck et al.   ORGANOMETALLICS

Coordination-Driven Self-Assembly and Anticancer Activity of Molecular Rectangles Containing Octahedral Ruthenium Metal Centers

(2011) Vaishali Vajpayee et al.   ORGANOMETALLICS

Synthesis, Characterization and Anticancer Activity of Porphyrin-Containing Organometallic Cubes

(2010) Nicolas P. E. Barry et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Platinum(II)−Dendrimer Conjugates: Synthesis and Investigations on Cytotoxicity, Cellular Distribution, Platinum Release, DNA, and Protein Binding

(2010) Timo Kapp et al.   BIOCONJUGATE CHEMISTRY

Guanidiniocarbonylpyrrole-Aryl Derivatives: Structure Tuning for Spectrophotometric Recognition of Specific DNA and RNA Sequences and for Antiproliferative Activity

(2010) Laura Hernandez-Folgado et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular architecture of redox-active half-sandwich Ru(ii) cyclic assemblies. Interactions with biomolecules and anticancer activity

(2010) Fátima Linares et al.   CRYSTENGCOMM

Anticancer activity of opened arene ruthenium metalla-assemblies

(2010) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Thiophenolato-bridged dinuclear arene ruthenium complexes: a new family of highly cytotoxic anticancer agents

(2010) Michaël Gras et al.   DALTON TRANSACTIONS

Antiproliferative activity of chelating N,O- and N,N-ruthenium(ii) arene functionalised poly(propyleneimine) dendrimer scaffolds

(2010) Preshendren Govender et al.   DALTON TRANSACTIONS

Photoactivated Biological Activity of Transition-Metal Complexes

(2010) Ulrich Schatzschneider   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA

(2010) Iztok Turel et al.   INORGANIC CHEMISTRY

Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting

(2010) Anna K. Renfrew et al.   INORGANIC CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adding diversity to ruthenium(II)–arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains

(2010) Anna K. Renfrew et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Organometallic ruthenium-based antitumor compounds with novel modes of action

(2010) Wee Han Ang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity

(2010) Lukas K. Filak et al.   ORGANOMETALLICS

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unusual DNA binding modes for metal anticancer complexes

(2009) Ana M. Pizarro et al.   BIOCHIMIE

Photocontrolled nucleobase binding to an organometallic RuII arene complex

(2009) Soledad Betanzos-Lara et al.   CHEMICAL COMMUNICATIONS

Biological activity of metal ions complexes of chromones, coumarins and flavones

(2009) Magdalena Grazul et al.   COORDINATION CHEMISTRY REVIEWS

Coordination chemistry of 1,3,5-triaza-7-phosphaadamantane (PTA) and derivatives. Part II. The quest for tailored ligands, complexes and related applications

(2009) Jorge Bravo et al.   COORDINATION CHEMISTRY REVIEWS

Interactions of ruthenium coordination cubes with DNA

(2009) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

(2009) Kenneth D. Camm et al.   DALTON TRANSACTIONS

Areneruthenium complexes as anticancer agents

(2009) Georg Süss-Fink   DALTON TRANSACTIONS

Synthesis, Characterization, and in vitro Antimalarial and Antitumor Activity of New Ruthenium(II) Complexes of Chloroquine

(2009) Chandima S. K. Rajapakse et al.   INORGANIC CHEMISTRY

Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

(2009) Maria G. Mendoza-Ferri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds

(2009) Preshendren Govender et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

(2009) Johan Mattsson et al.   ORGANOMETALLICS

Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta

(2009) Anna K. Renfrew et al.   ORGANOMETALLICS

Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on thein VitroAntitumor Activity of Polynuclear Organometallic Compounds

(2009) Maria G. Mendoza-Ferri et al.   ORGANOMETALLICS

Rational Design of Highly Cytotoxic η6-Arene β-Diketiminato−Ruthenium Complexes

(2009) Andrew D. Phillips et al.   ORGANOMETALLICS

Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity

(2008) Peng Xie et al.   ACS Chemical Biology

The “Complex-in-a-Complex” Cations [(acac)2M⊂Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A Trojan Horse for Cancer Cells

(2008) Bruno Therrien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry. Short Communication

(2008) Michael Groessl et al.   CHEMISTRY & BIODIVERSITY

Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents

(2008) Anna F. A. Peacock et al.   Chemistry-An Asian Journal

Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6-p-cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5-triaza-7-phosphaadamantane)

(2008) Carsten A. Vock et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

The Contrasting Chemistry and Cancer Cell Cytotoxicity of Bipyridine and Bipyridinediol Ruthenium(II) Arene Complexes

(2008) Tijana Bugarcic et al.   INORGANIC CHEMISTRY

Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes

(2008) Maria Castellano-Castillo et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

(2008) Frédéric Schmitt et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cytotoxicity, Cellular Uptake, and DNA Interactions of New Monodentate Ruthenium(II) Complexes Containing Terphenyl Arenes

(2008) Tijana Bugarcic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Copper(II) Complex ofN-Propyl-norfloxacin and 1,10-Phenanthroline with Enhanced Antileukemic and DNA Nuclease Activities

(2008) Maria E. Katsarou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer

(2008) Frédéric Schmitt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells

(2008) Wee Han Ang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

DNA Structural Distortions Induced by Ruthenium−Arene Anticancer Compounds

(2008) Christian Gossens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

(2008) Jasna Maksimoska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Encapsulation of Aromatic Molecules in Hexanuclear Arene Ruthenium Cages: A Strategy to Build Up Organometallic Carceplex Prisms with a Dangling Arm Standing Out

(2008) Johan Mattsson et al.   ORGANOMETALLICS

Influence of the Spacer Length on thein VitroAnticancer Activity of Dinuclear Ruthenium−Arene Compounds

(2008) Maria-Grazia Mendoza-Ferri et al.   ORGANOMETALLICS

Importance of the π-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

(2008) Barnali Dutta et al.   ORGANOMETALLICS

Catalytic organometallic anticancer complexes

(2008) S. J. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties:  Synthesis, Structure, Electrochemistry, and Cytotoxicity

(2007) Mathieu Auzias et al.   INORGANIC CHEMISTRY

Studies on the reactivity of organometallic Ru–, Rh– and Os–pta complexes with DNA model compounds

(2007) Antoine Dorcier et al.   JOURNAL OF INORGANIC BIOCHEMISTRY