Designing organometallic compounds for catalysis and therapy

Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor

(2012) Soledad Betanzos-Lara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal Complexes as DNA Intercalators

(2011) Hong-Ke Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity

(2011) Eric Meggers   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anticancer Activity of Metal Complexes: Involvement of Redox Processes

(2011) Ute Jungwirth et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential Antibacterial Activity Against Pseudomonas aeruginosa by Carbon Monoxide-Releasing Molecules

(2011) Mathieu Desmard et al.   ANTIOXIDANTS & REDOX SIGNALING

Photoenzymatic synthesis through sustainable NADH regeneration by SiO2-supported quantum dots

(2011) Sahng Ha Lee et al.   CHEMICAL COMMUNICATIONS

A visible-light-driven transfer hydrogenation on CdS nanoparticles combined with iridium complexes

(2011) Jun Li et al.   CHEMICAL COMMUNICATIONS

Double Targeting of Tumours with Pyrenyl-Modified Dendrimers Encapsulated in an Arene-Ruthenium Metallaprism

(2011) Anaïs Pitto-Barry et al.   CHEMISTRY-A EUROPEAN JOURNAL

Encapsulation of Pyrene-Functionalized Poly(benzyl ether) Dendrons into a Water-Soluble Organometallic Cage

(2011) Anaïs Pitto-Barry et al.   Chemistry-An Asian Journal

Study of the Anticancer Properties of Tin(IV) Carboxylate Complexes on a Panel of Human Tumor Cell Lines

(2011) Lourdes Rocamora-Reverte et al.   ChemMedChem

From Catalysts to Bioactive Organometallics: Do Grubbs Catalysts Trigger Biological Effects?

(2011) Luciano Oehninger et al.   ChemMedChem

CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke*

(2011) Andriy Yabluchanskiy et al.   CRITICAL CARE MEDICINE

Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity

(2011) Ying Fu et al.   DALTON TRANSACTIONS

Anticancer activity of tetracationic arene ruthenium metalla-cycles

(2011) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Organometalliccis-Dichlorido Ruthenium(II) Ammine Complexes

(2011) Soledad Betanzos-Lara et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex

(2011) Federico Giannini et al.   INORGANIC CHEMISTRY

Cooperative catalysis of a trinuclear ruthenium(II) complex in transfer hydrogenation of ketones by formic acid

(2011) Yuichi Yano et al.   INORGANICA CHIMICA ACTA

PhotoCORMs: Light-triggered release of carbon monoxide from the coordination sphere of transition metal complexes for biological applications

(2011) Ulrich Schatzschneider   INORGANICA CHIMICA ACTA

Organometallic Half-Sandwich Iridium Anticancer Complexes

(2011) Zhe Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal-Based Inhibition of Poly(ADP-ribose) Polymerase − The Guardian Angel of DNA

(2011) Filipa Mendes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Experimental Investigations of a Partial Ru–O Bond during the Metal–Ligand Bifunctional Addition in Noyori-Type Enantioselective Ketone Hydrogenation

(2011) Satoshi Takebayashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Catalytic Interconversion between NADH and NAD+ Accompanied by Generation and Consumption of Hydrogen with a Water-Soluble Iridium Complex at Ambient Pressure and Temperature

(2011) Yuta Maenaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex

(2011) Flavia Barragán et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Titanocene anticancer complexes and their binding mode of action to human serum albumin: A computational study

(2011) Susan W. Sarsam et al.   Metallomics

Differences in the Cellular Response and Signaling Pathways between Cisplatin and Monodentate Organometallic Ru(II) Antitumor Complexes Containing a Terphenyl Ligand

(2011) Anna Kisova et al.   MOLECULAR PHARMACEUTICS

Physicochemical Studies and Anticancer Potency of Ruthenium η6-p-Cymene Complexes Containing Antibacterial Quinolones

(2011) Jakob Kljun et al.   ORGANOMETALLICS

An Iridium(IV) Species, [Cp*Ir(NHC)Cl]+, Related to a Water-Oxidation Catalyst

(2011) Timothy P. Brewster et al.   ORGANOMETALLICS

Pincer-type Pyridine-Based N-Heterocyclic Carbene Amine Ru(II) Complexes as Efficient Catalysts for Hydrogen Transfer Reactions

(2011) Carolina del Pozo et al.   ORGANOMETALLICS

Artificial Metalloenzymes Based on the Biotin−Avidin Technology: Enantioselective Catalysis and Beyond

(2010) Thomas R. Ward   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure

(2010) Rodrigo Arancibia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons

(2010) Jia Liu et al.   CHEMICAL COMMUNICATIONS

Catalysis by Palladium Pincer Complexes

(2010) Nicklas Selander et al.   CHEMICAL REVIEWS

Organic Reactions Catalyzed by Rhenium Carbonyl Complexes

(2010) Yoichiro Kuninobu et al.   CHEMICAL REVIEWS

Energetics, Conformation, and Recognition of DNA Duplexes Modified by Monodentate RuIIComplexes Containing Terphenyl Arenes

(2010) Olga Novakova et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral η6-Arene/N-Tosylethylenediamine-Ruthenium(II) Complexes: Solution Behavior and Catalytic Activity for Asymmetric Hydrogenation

(2010) Christian A. Sandoval et al.   Chemistry-An Asian Journal

Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells

(2010) Meral Görmen et al.   ChemMedChem

Anticancer activity of osmium metalla-rectangles

(2010) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Anticancer activity of opened arene ruthenium metalla-assemblies

(2010) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT

(2010) Angela Casini et al.   DALTON TRANSACTIONS

Controlling the Reactivity of Ruthenium(II) Arene Complexes by Tether Ring-Opening

(2010) Ana M. Pizarro et al.   INORGANIC CHEMISTRY

First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA

(2010) Iztok Turel et al.   INORGANIC CHEMISTRY

Is the Reactivity of M(II)−Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter?

(2010) Muhammad Hanif et al.   INORGANIC CHEMISTRY

Synthetic and Mechanistic Pathways ofCisandTrans-Hydroxytamoxifen Drug Derivatives Reacting with Cp*Rh Complexes that involve η1-N, η2-N,O, η1-O, and η6Bonding Modes, via a Novel N-π Rearrangement; Relative Binding Affinities and Computer Docking Studies ofCis and Trans-η6-Cp*Rh-Hydroxytamoxifen Complexes at the Estrogen, ERα and ERβ Receptors, and Growth Inhibition to Breast Cancer Cells

(2010) Siden Top et al.   INORGANIC CHEMISTRY

From hydrolytically labile to hydrolytically stable RuII–arene anticancer complexes with carbohydrate-derived co-ligands

(2010) Muhammad Hanif et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Development of Bimetallic Titanocene−Ruthenium−Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties

(2010) Frédéric Pelletier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Osmium Arene Complexes with Potent Cancer Cell Cytotoxicity

(2010) Ying Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic ruthenium-based antitumor compounds with novel modes of action

(2010) Wee Han Ang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and Preliminary Cytotoxicity Studies of Achiral Indolyl-Substituted Titanocenes

(2010) Megan Hogan et al.   ORGANOMETALLICS

Synthesis and Structure of Protic Amine Tethered Rhodium(III) Peralkylcyclopentadienyl Complexes

(2010) Masato Ito et al.   ORGANOMETALLICS

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity

(2010) Lukas K. Filak et al.   ORGANOMETALLICS

Asymmetric Transfer Hydrogenation in Water with Platinum Group Metal Catalysts

(2010) Xiaofeng Wu et al.  

Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene RuII anticancer complex

(2010) Hong-Ke Liu et al.   Chemical Science

Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

(2009) Didier Hamels et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetaldehyde from Ethylene-A Retrospective on the Discovery of the Wacker Process

(2009) Reinhard Jira   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocontrolled nucleobase binding to an organometallic RuII arene complex

(2009) Soledad Betanzos-Lara et al.   CHEMICAL COMMUNICATIONS

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

The Medicinal Applications of Imidazolium Carbene−Metal Complexes

(2009) Khadijah M. Hindi et al.   CHEMICAL REVIEWS

Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts†

(2009) Georgios C. Vougioukalakis et al.   CHEMICAL REVIEWS

Arene Control over Thiolate to Sulfinate Oxidation in Albumin by Organometallic Ruthenium Anticancer Complexes

(2009) Wenbing Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro

(2009) Wolfgang Kandioller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Evidence for Drug Release from a Metalla-Cage Delivery Vector Following Cellular Internalisation

(2009) Olivier Zava et al.   CHEMISTRY-A EUROPEAN JOURNAL

Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds

(2009) Ouardia Zekri et al.   DALTON TRANSACTIONS

Inert ruthenium half-sandwich complexes with anticancer activity

(2009) Eric Meggers et al.   DALTON TRANSACTIONS

A novel ruthenium(ii) arene based intercalator with potent anticancer activity

(2009) José Ruiz et al.   DALTON TRANSACTIONS

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

(2009) Yong Leng Kelvin Tan et al.   DALTON TRANSACTIONS

Interactions of ruthenium coordination cubes with DNA

(2009) Nicolas P. E. Barry et al.   DALTON TRANSACTIONS

Areneruthenium complexes as anticancer agents

(2009) Georg Süss-Fink   DALTON TRANSACTIONS

Organometallic compounds in oncology: implications of novel organotins as antitumor agents

(2009) Angela Alama et al.   DRUG DISCOVERY TODAY

Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity

(2009) Sanja Grgurić-Šipka et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium’s success?

(2009) Simon M Page et al.   Future Medicinal Chemistry

Organometallic Osmium(II) Arene Anticancer Complexes Containing Picolinate Derivatives

(2009) Sabine H. van Rijt et al.   INORGANIC CHEMISTRY

Ruthenium(II) Arene Anticancer Complexes with Redox-Active Diamine Ligands

(2009) Tijana Bugarcic et al.   INORGANIC CHEMISTRY

In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model

(2009) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Binding and hydrolysis studies of antitumoural titanocene dichloride and Titanocene Y with phosphate diesters

(2009) Andrea Erxleben et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Toward the Development of a Potent and Selective Organoruthenium Mammalian Sterile 20 Kinase Inhibitor

(2009) Ruchi Anand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amide Linkage Isomerism As an Activity Switch for Organometallic Osmium and Ruthenium Anticancer Complexes

(2009) Sabine H. van Rijt et al.   JOURNAL OF MEDICINAL CHEMISTRY

A [3]Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines

(2009) Damian Plażuk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxicity, Hydrophobicity, Uptake, and Distribution of Osmium(II) Anticancer Complexes in Ovarian Cancer Cells

(2009) Sabine H. van Rijt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aqueous organometallic chemistry. 3. Catalytic hydride transfer reactions with ketones and aldehydes using [Cp∗Rh(bpy)(H2O)](OTf)2 as the precatalyst and sodium formate as the hydride source: Kinetic and activation parameters, and the significance of steric and electronic effects

(2009) Carmen Leiva et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Binding of Organometallic Ruthenium(II) Anticancer Compounds to Nucleobases: A Computational Study†

(2009) Christian Gossens et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Influence of Oxygenation on the Reactivity of Ruthenium−Thiolato Bonds in Arene Anticancer Complexes: Insights from XAS and DFT

(2009) Thamayanthy Sriskandakumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Active and Robust Cp* Iridium Complexes for Catalytic Water Oxidation

(2009) Jonathan F. Hull et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: Ion mobility mass spectrometry and modeling

(2009) Jonathan P. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action

(2009) Angela Casini et al.   Metallomics

Base-Free Transfer Hydrogenation of Ketones Using Arene Ruthenium(II) Complexes

(2009) M. Carmen Carrión et al.   ORGANOMETALLICS

Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide

(2009) Jonathan P. Williams et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Metal and Ligand Control of Sulfenate Reactivity: Arene Ruthenium Thiolato-Mono-S-Oxides

(2008) Holm Petzold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The “Complex-in-a-Complex” Cations [(acac)2M⊂Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A Trojan Horse for Cancer Cells

(2008) Bruno Therrien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media

(2008) Olga Nováková et al.   BIOCHEMICAL PHARMACOLOGY

Oxidation induced by the antioxidant glutathione (GSH)

(2008) Holm Petzold et al.   CHEMICAL COMMUNICATIONS

Bioorganometallic fulvene-derived titanocene anti-cancer drugs

(2008) Katja Strohfeldt et al.   CHEMICAL SOCIETY REVIEWS

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

A Multilateral Mechanistic Study into Asymmetric Transfer Hydrogenation in Water

(2008) Xiaofeng Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Functionalised η6-arene ruthenium complexes

(2008) Bruno Therrien   COORDINATION CHEMISTRY REVIEWS

Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs

(2008) Olivia R. Allen et al.   DALTON TRANSACTIONS

In vitro cytotoxic activity of tri-n-butyltin(IV)lupinylsulfide hydrogen fumarate (IST-FS 35) and preliminary antitumor activity in vivo

(2008) Angela Alama et al.   INVESTIGATIONAL NEW DRUGS

Cytotoxicity, Cellular Uptake, and DNA Interactions of New Monodentate Ruthenium(II) Complexes Containing Terphenyl Arenes

(2008) Tijana Bugarcic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs

(2008) Anne Vessières et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Catalytic organometallic anticancer complexes

(2008) S. J. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies on the reactivity of organometallic Ru–, Rh– and Os–pta complexes with DNA model compounds

(2007) Antoine Dorcier et al.   JOURNAL OF INORGANIC BIOCHEMISTRY