Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Anticancer metallodrug research analytically painting the “omics” picture—current developments and future trends

(2012) Michael Groessl et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Laser ablation ICP-MS for quantitative biomedical applications

(2012) Ioana Konz et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Probing the Interaction of Cisplatin with Cytochrome c by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2012) Ningbo Zhang et al.   ANALYTICAL CHEMISTRY

Tandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeutics

(2012) Catherine Silvestri et al.   MASS SPECTROMETRY REVIEWS

Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells

(2012) Dirk A. Wolters et al.   Metallomics

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

(2011) Samuel M. Meier et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Use of Top-Down and Bottom-Up Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Mapping Calmodulin Sites Modified by Platinum Anticancer Drugs

(2011) Huilin Li et al.   ANALYTICAL CHEMISTRY

Elemental Bioimaging in Kidney by LA–ICP–MS As a Tool to Study Nephrotoxicity and Renal Protective Strategies in Cisplatin Therapies

(2011) Estefanía Moreno-Gordaliza et al.   ANALYTICAL CHEMISTRY

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

(2011) Bin Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bioanalytical and Biophysical Techniques for the Elucidation of the Mode of Action of Metal-Based Drugs

(2011) Michael Groessl et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular Mechanisms and Proposed Targets for Selected Anticancer Gold Compounds

(2011) Angela Casini et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biomolecule binding vs. anticancer activity: Reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins

(2011) Samuel M. Meier et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma

(2011) Anna K. Bytzek et al.   Metallomics

Novel insights into the bottom-up mass spectrometry proteomics approach for the characterization of Pt-binding proteins: The insulin-cisplatin case study

(2010) Estefanía Moreno-Gordaliza et al.   ANALYST

Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS

(2010) Michael Groessl et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry

(2010) Michael Groessl et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Targeted quantitative analysis of superoxide dismutase 1 in cisplatin-sensitive and cisplatin-resistant human ovarian cancer cells

(2010) Jong Won Kim et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Shape changes induced by N-terminal platination of ubiquitin by cisplatin

(2010) Jonathan P. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney

(2010) Amina Bouslimani et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

(2009) Frederike Lentz et al.   ANTI-CANCER DRUGS

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Exploring metallodrug–protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

(2009) Angela Casini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Direct determination of the primary binding site of cisplatin on cytochrome c by mass spectrometry

(2009) Ting Zhao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action

(2009) Angela Casini et al.   Metallomics

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands

(2008) Isabella Berger et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbohydrate-Metal Complexes and their Potential as Anticancer Agents

(2008) Christian Hartinger et al.   CURRENT MEDICINAL CHEMISTRY

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

(2008) Michael Groessl et al.   ELECTROPHORESIS

High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides

(2008) Alexander E. Egger et al.   INORGANIC CHEMISTRY

Peculiar mechanistic and structural features of the carboplatin–cytochrome c system revealed by ESI-MS analysis

(2008) Chiara Gabbiani et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Stability of an organometallic ruthenium–ubiquitin adduct in the presence of glutathione: Relevance to antitumour activity

(2008) Christian G. Hartinger et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Analytical methodologies for the determination of cisplatin

(2008) M. Espinosa Bosch et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

(2008) Elke E.M. Brouwers et al.   MASS SPECTROMETRY REVIEWS

Identification and characterization of metallodrug binding proteins by (metallo)proteomics

(2008) Xuesong Sun et al.   Metallomics

Antitumour metal compounds: more than theme and variations

(2007) Michael A. Jakupec et al.   DALTON TRANSACTIONS

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

(2007) Christian G. Hartinger et al.   INORGANIC CHEMISTRY

Studies on the reactivity of organometallic Ru–, Rh– and Os–pta complexes with DNA model compounds

(2007) Antoine Dorcier et al.   JOURNAL OF INORGANIC BIOCHEMISTRY